在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MCTS1 Antibody

MCTS1 Antibody

  • 中文名稱：
    MCTS1兔多克隆抗體
  • 貨號：
    CSB-PA892143HA01HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA892143HA01HU at dilution of 1:100
    • Immunofluorescence staining of PC-3 cells with CSB-PA892143HA01HU at 1:266, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) MCTS1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MCTS1
  • 別名：
    FLJ39637 antibody; Malignant T cell amplified sequence 1 antibody; Malignant T cell-amplified sequence 1 antibody; MCT 1 antibody; MCT-1 antibody; MCT1 antibody; MCTS 1 antibody; MCTS1 antibody; MCTS1_HUMAN antibody; Multiple copies T cell malignancies 1 antibody; Multiple copies T cell malignancies antibody; Multiple copies T-cell malignancies antibody; Oncogene MCT 1 antibody; Oncogene MCT1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Malignant T-cell-amplified sequence 1 protein (1-181AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，MCTS1 Antibody (CSB-PA892143HA01HU)，的標記方式是Non-conjugated。對于MCTS1 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA892143HB01HU MCTS1 Antibody, HRP conjugated ELISA
    FITC CSB-PA892143HC01HU MCTS1 Antibody, FITC conjugated
    Biotin CSB-PA892143HD01HU MCTS1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:200-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constitutively expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; up-regulates protein levels of BCL2L2, TFDP1, MRE11, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiple chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3. Involved in translation initiation; promotes aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.
  • 基因功能參考文獻：
    1. PKC inhibitor sotrastaurin induced cell apoptosis and cell cycle arrest in DLBCL cells potentially through regulating the expression of MCT-1 PMID: 29534146
    2. findings elucidate how the DENR-MCT-1 dimer interacts with the ribosome and have functional implications for the mechanism of unconventional translation initiation and reinitiation. PMID: 28723557
    3. DENR binds to the P-site of the 40S ribosomal subunit and together with MCTS1 forms a tRNA binding surface and interferes with eIF1/eIF2/eIF3 binding, thus operating in post-termination ribosome recycling and translation re-initiation PMID: 28723557
    4. Reinitiation complexes involving initiation factors eIF2D, MCT-1, and DENR controls the translation of a large fraction of mammalian cellular mRNAs. PMID: 28732596
    5. Overexpression of MCT1 is associated with gliomas. PMID: 23258846
    6. MCT-1 is a new centrosomal-associated oncoprotein, and that it plays a novel role in the regulation of mitosis signifies its important function in the process of tumorigenesis. PMID: 22336915
    7. The present study indicates possible involvement of a protein kinase (PK)C- and PKA-mediated pathway associated with expression of MCT1 and lactate transport in rhabdomyosarcoma cells. PMID: 20823576
    8. The oppositions between MCT-1 and p53 are firstly confirmed at multistage processes that include transcription control, mRNA metabolism, and protein expression PMID: 21138557
    9. The result suggest that co-expression of CD147 and MCT1/MCT4 is related to drug resistance during EOC metastasis and could be useful therapeutic targets to prevent the development of incurable, recurrent and drug resistance EOC. PMID: 20658178
    10. Results describe the expression and purification of MCT-1 in insect cells using a baculovirus expression system. PMID: 20076993
    11. tumor cell lines overexpressing MCT-1 exhibited increased growth rates and displayed increased protection against apoptosis induced by serum starvation PMID: 12637315
    12. demonstrated the presence of sequence-specific DNA-binding protein in nuclear extracts designated as LMBF; the 26-mer oligonucleotide containing the LMBF binding site is required for maximum transcriptional activity of the MCT-1 promoter PMID: 12938157
    13. role of the MCT-1 in lymphomagenesis PMID: 18824261
    14. Loss of p53 and MCT-1 overexpression synergistically promote chromosome instability and tumorigenicity. PMID: 19372582

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Note=Nuclear relocalization after DNA damage.
  • 蛋白家族：
    MCTS1 family
  • 組織特異性：
    Ubiquitous. Over-expressed in T-cell lymphoid cell lines and in non-Hodgkin lymphoma cell lines as well as in a subset of primary large B-cell lymphomas.
  • 數據庫鏈接：

    HGNC: 23357

    OMIM: 300587

    KEGG: hsa:28985

    STRING: 9606.ENSP00000360365

    UniGene: Hs.102696



主站蜘蛛池模板： 久久综合九色综合网站| 尤物蜜芽国产成人精品区| 久久精品亚洲精品无码| 国产成a人亚洲精v品无码性色| 国产色爱av资源综合区| 欧美疯狂性受xxxxx另类| 色综合色欲色综合色综合色综合r| 中文字幕无码专区人妻系列| 日本丰满大乳乳液| 又粗又长又硬义又黄又爽| 亚洲人成电影网站色www| 护士脱了内裤让我爽了一夜视频| 国产午费午夜福利200集| 亚洲欧美日韩_欧洲日韩| 国偷自产视频一区二区久| 波多野结衣av手机在线观看 | 国产口爆吞精在线视频2020版| 国产肉体xxxx裸体137大胆| 久久久久久久精品成人执小说一白| 国产女人乱子对白av片| 亚洲成a人片在线不卡一二三区| 玩弄漂亮少妇高潮白浆| 熟女乱牛牛视频在线观看| 天天躁日日躁狠狠躁视频2021| 国产熟妇搡bbbb搡bbbb搡| 国产精品无打码在线播放| 人人婷婷人人澡人人爽| 人妻少妇88久久中文字幕| 国产乱色国产精品播放视频 | 精产一二三产区m553| 九色porny丨国产首页注册| 国产精品久久久久久爽爽爽床戏| 国产熟妇乱子伦视频在线观看| 8x8ⅹ在线永久免费入口| 国产精品久久久久秋霞鲁丝 | 欧美成人精品一区二区综合a片| 四库影院永久四虎精品国产 | 亚洲老熟女与小伙bbwtv| 一本一本久久a久久精品综合| 色v99在线影院| 激情综合色综合啪啪五月丁香搜索 |