在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MCTS1 Antibody

MCTS1 Antibody

  • 中文名稱：
    MCTS1兔多克隆抗體
  • 貨號：
    CSB-PA200543
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA200543(MCTS1 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA200543(MCTS1 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Jurkat cells, PC3 cells, Primary antibody: CSB-PA200543(MCTS1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    MCTS1
  • 別名：
    FLJ39637 antibody; Malignant T cell amplified sequence 1 antibody; Malignant T cell-amplified sequence 1 antibody; MCT 1 antibody; MCT-1 antibody; MCT1 antibody; MCTS 1 antibody; MCTS1 antibody; MCTS1_HUMAN antibody; Multiple copies T cell malignancies 1 antibody; Multiple copies T cell malignancies antibody; Multiple copies T-cell malignancies antibody; Oncogene MCT 1 antibody; Oncogene MCT1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Fusion protein of Human MCTS1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:100-1:300
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constitutively expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; up-regulates protein levels of BCL2L2, TFDP1, MRE11, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiple chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3. Involved in translation initiation; promotes aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.
  • 基因功能參考文獻：
    1. PKC inhibitor sotrastaurin induced cell apoptosis and cell cycle arrest in DLBCL cells potentially through regulating the expression of MCT-1 PMID: 29534146
    2. findings elucidate how the DENR-MCT-1 dimer interacts with the ribosome and have functional implications for the mechanism of unconventional translation initiation and reinitiation. PMID: 28723557
    3. DENR binds to the P-site of the 40S ribosomal subunit and together with MCTS1 forms a tRNA binding surface and interferes with eIF1/eIF2/eIF3 binding, thus operating in post-termination ribosome recycling and translation re-initiation PMID: 28723557
    4. Reinitiation complexes involving initiation factors eIF2D, MCT-1, and DENR controls the translation of a large fraction of mammalian cellular mRNAs. PMID: 28732596
    5. Overexpression of MCT1 is associated with gliomas. PMID: 23258846
    6. MCT-1 is a new centrosomal-associated oncoprotein, and that it plays a novel role in the regulation of mitosis signifies its important function in the process of tumorigenesis. PMID: 22336915
    7. The present study indicates possible involvement of a protein kinase (PK)C- and PKA-mediated pathway associated with expression of MCT1 and lactate transport in rhabdomyosarcoma cells. PMID: 20823576
    8. The oppositions between MCT-1 and p53 are firstly confirmed at multistage processes that include transcription control, mRNA metabolism, and protein expression PMID: 21138557
    9. The result suggest that co-expression of CD147 and MCT1/MCT4 is related to drug resistance during EOC metastasis and could be useful therapeutic targets to prevent the development of incurable, recurrent and drug resistance EOC. PMID: 20658178
    10. Results describe the expression and purification of MCT-1 in insect cells using a baculovirus expression system. PMID: 20076993
    11. tumor cell lines overexpressing MCT-1 exhibited increased growth rates and displayed increased protection against apoptosis induced by serum starvation PMID: 12637315
    12. demonstrated the presence of sequence-specific DNA-binding protein in nuclear extracts designated as LMBF; the 26-mer oligonucleotide containing the LMBF binding site is required for maximum transcriptional activity of the MCT-1 promoter PMID: 12938157
    13. role of the MCT-1 in lymphomagenesis PMID: 18824261
    14. Loss of p53 and MCT-1 overexpression synergistically promote chromosome instability and tumorigenicity. PMID: 19372582

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Note=Nuclear relocalization after DNA damage.
  • 蛋白家族：
    MCTS1 family
  • 組織特異性：
    Ubiquitous. Over-expressed in T-cell lymphoid cell lines and in non-Hodgkin lymphoma cell lines as well as in a subset of primary large B-cell lymphomas.
  • 數據庫鏈接：

    HGNC: 23357

    OMIM: 300587

    KEGG: hsa:28985

    STRING: 9606.ENSP00000360365

    UniGene: Hs.102696



主站蜘蛛池模板： 少妇被躁爽到高潮无码久久 | 国产做爰xxxⅹ久久久精华液| 啦啦啦www播放日本观看| 精品国产一区av天美传媒| 综合激情久久综合激情 | 无人区一码卡二卡三乱码| 亚洲夂夂婷婷色拍ww47 | 最新永久无码av网址亚洲| 亚洲精品一区二区国产精华液| 中字幕一区二区三区乱码| 欧美老妇大p毛茸茸| 高清粉嫩无套内谢国语播放| 色综合欧美五月俺也去| 影音先锋久久久久av综合网成人| 少妇极品熟妇人妻无码| 久久精品亚洲精品国产色婷| 97国产在线看片免费人成视频| 亚洲成av人片一区二区梦乃| 国内精品国产三级国产av| 久久不见久久见www免费| 国产产在线精品亚洲aavv| 亚洲高清最新av网站| 男女超爽视频免费播放| 国产欧美综合在线观看第十页| 欧美人妻少妇精品久久黑人| 真实的国产乱xxxx在线| 久久超碰精品一夜七次郎| 免费国产黄网站在线观看可以下载| 精品人妻少妇一区二区三区| 久久久久久毛片免费播放| 十八禁啪啪无遮挡网站| 国产精品一区二区 尿失禁| 一本色道久久综合狠狠躁篇| 国产3p露脸普通话对白| 久久综合九色欧美综合狠狠| 精品偷拍被偷拍在线观看| 涩欲国产一区二区三区四区| 亚洲午夜无码av毛片久久| 亚洲另类欧美综合在线| 精品一区二区三区在线播放视频 | 亚洲综合av色婷婷|