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  4. CCNL1 Antibody

CCNL1 Antibody

  • 中文名稱：
    CCNL1兔多克隆抗體
  • 貨號(hào)：
    CSB-PA001903
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of HepG2 cells using Cyclin L1 Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    CCNL1 antibody; BM-001 antibody; UNQ530/PRO1073 antibody; Cyclin-L1 antibody; Cyclin-L antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human Cyclin L1.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs). Inhibited by the CDK-specific inhibitor CDKN1A/p21. May play a role in the regulation of RNA polymerase II (pol II). May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC).
  • 基因功能參考文獻(xiàn)：
    1. Results suggest that LEKR1-CCNL1 and IGSF21-KLHDC7A gene polymorphisms influence the development of diabetic retinopathy (DR). PMID: 27607899
    2. CCNL1 is the target gene of miR-199b-5p. PMID: 26043836
    3. Data indicate that if the newborn carried a risk allele rs900400 near LEKR/CCNL1, the impact of stress on birth size was stronger. PMID: 22685556
    4. birth weight lowering effect of the C-allele of rs900400 located near LEKR1 and CCNL1 was replicated in the Danish population. Furthermore the C-allele was associated with increased insulin response following oral glucose stimulation PMID: 22073261
    5. Data show low birth weight in Asian Indians is not due to variation near CCNL1/ADCY5, but variant ADCY5 is associated with elevated glucose/decreased insulin response which suggests a common genetic cause of low birth weight and risk of type 2 diabetes. PMID: 21712988
    6. These data demonstrate that there is a fine balance between CCNL1 and TIMP1, which may contribute to breast cancer development. PMID: 21586274
    7. Our results suggest that a genetic variant of ccnl1 leads to symmetric growth restriction from early pregnancy onward PMID: 21307140
    8. Cyclin L1 amplification is associated with uterine cervical carcinoma. PMID: 20721974
    9. variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight PMID: 20372150
    10. role in pre-mRNA splicing PMID: 11980906
    11. Our results indicate that CCNL1 plays a critical role in the loco-regional progression of HNSCC and may serve as an indicator for occult advanced tumour stages. PMID: 15700036
    12. study suggests that cyclin l1 may have a role in RNA processing complex anc ould participate in tumor progression of head and neck squamous cell carcinoma PMID: 16598186
    13. Data show that a green fluorescent protein (GFP) fusion protein of cyclin L1, in contrast to cyclin L2, was not mobile within the nucleus of living COS7 cells. PMID: 17494991
    14. CDK11(p110) interacts physically and functionally with cyclin Lalpha and -beta isoforms and SR proteins to regulate splicing. PMID: 18216018
    15. Cyclin L has been shown to associate with the PITSLRE kinase and is involved in pre-mRNA processing. PMID: 11980906

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  • 亞細(xì)胞定位：
    Nucleus speckle. Nucleus, nucleoplasm.
  • 蛋白家族：
    Cyclin family, Cyclin L subfamily
  • 組織特異性：
    Widely expressed. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC).
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 20569

    OMIM: 613384

    KEGG: hsa:57018

    STRING: 9606.ENSP00000295926

    UniGene: Hs.4859



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