在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SCAP Antibody

SCAP Antibody

  • 中文名稱：
    SCAP兔多克隆抗體
  • 貨號(hào)：
    CSB-PA277938
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA277938(SCAP Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA277938(SCAP Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    KIAA0199 antibody; SCAP antibody; SCAP_HUMAN antibody; SREBF chaperone antibody; SREBF chaperone protein antibody; SREBP cleavage activating protein antibody; SREBP cleavage-activating protein antibody; Sterol regulatory element binding protein cleavage-activating protein antibody; Sterol regulatory element-binding protein cleavage-activating protein antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human SCAP
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum. Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway. Binds cholesterol via its SSD domain.
  • 基因功能參考文獻(xiàn)：
    1. Polymorphism in SCAP gene is associated with high blood pressure. PMID: 28542467
    2. These insights suggest a new structural model for cholesterol-mediated regulation of Scap activity. PMID: 28377508
    3. The genetic polymorphisms of SREBF1 could play a role in the mechanism for interindividual variation of atypical antipsychotics-induced metabolic syndrome (MetS). SCAP polymorphisms with drug-induced MetS were negative in this study. PMID: 26982812
    4. this study uncovered a novel function of SCAP of counteracting the inhibitory action of Dengue Virus NS2B3 protease on STING signaling, suggesting that modulation of SCAP levels may have therapeutic implications. PMID: 28228593
    5. Data indicate that glucose-mediated glycosylation promotes SREBP cleavage-activating protein (SCAP) trafficking to the Golgi Leading to sterol regulatory element binding protein 1 (SREBP-1) activation. PMID: 26555173
    6. identified interaction of three genes in INSIG-SCAP-SREBP pathway on risk of obesity, revealing that these genes affect obesity more likely through a complex interaction pattern than single gene effect. PMID: 25028659
    7. Enhanced SCAP glycosylation by inflammation induces macrophage foam cell formation. PMID: 24146768
    8. SCAP gene polymorphisms decrease the risk of nonalcoholic fatty liver disease in females with metabolic syndrome. PMID: 24371177
    9. SREBP cleavage regulates Golgi-to-endoplasmic reticulum recycling of SREBP cleavage-activating protein (SCAP) PMID: 24478315
    10. A point mutation in Scap Loop 7 prevents interaction with Loop 1 and abolishes endoplasmic reticulum exit. PMID: 23564452
    11. the SCAP/SREBP signaling axis has a role in protecting cancer cells from lipotoxicity PMID: 23440422
    12. Data indicate that SREBP-2 and Scap are regulated by factors driving prostate growth, and suggest exploring this observation further could shed light on prostate carcinogenesis. PMID: 23454642
    13. could not identify any association between SREBF-2 1784G > C or SCAP 2386A > G SNPs and premature coronary artery disease or extent of coronary lesions in a Chinese population. PMID: 20111910
    14. TNF alpha upregulates the expression of SCAP and promotes the synthesis of triglyceride in cultured steatotic hepatocytes. PMID: 17963605
    15. Required for sterol-regulated transport of SREBPs from ER to Golgi. PMID: 12842885
    16. A possible gene-gene interaction between the genes encoding SREBP-2 and SCAP that modulate plasma lipids in a strictly gender-specific fashion. PMID: 16466730
    17. SCAP polymorphism appeared to modify the associations of SREBF-2 genotype with myocardial infarction risk among men. PMID: 17383658

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein.
  • 蛋白家族：
    WD repeat SCAP family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 30634

    OMIM: 601510

    KEGG: hsa:22937

    STRING: 9606.ENSP00000265565

    UniGene: Hs.531789



主站蜘蛛池模板： 久久精品蜜芽亚洲国产av| 久久天天躁夜夜躁狠狠85台湾| 久久精品av麻豆| 久久精品国产99久久无毒不卡 | 少妇一边呻吟一边说使劲视频 | 99久久99久久精品免费观看| 无码h黄肉3d动漫在线观看| 国产精品久久毛片av大全日韩| 免费又黄又裸乳的视频| 国产蜜芽尤物在线一区| 青青草在在观免费福利线观看| 久久久国产精品黄毛片| 国产精品宾馆在线精品酒店| 亚洲免费人成在线视频观看| 精品爆乳一区二区三区无码av| 在线亚洲日产一区二区| 免费va人成视频网站全| 婷婷综合缴情亚洲狠狠小说| 18禁黄网站禁片免费观看| 蜜桃成人无码区免费视频网站| 捆绑白丝粉色jk震动捧喷白浆| 高潮潮喷奶水飞溅视频无码| 永久免费无码av网站在线观看| 少妇脱了内裤让我添| 日本熟妇色一本在线观看| 中国凸偷窥xxxx自由视频| 欧美日本免费一区二区三区| 久久在线视频免费观看| 色资源av中文无码先锋| 国产白嫩护士在线播放| 日本xxxx片免费观看| 西西人体www大胆高清视频| 欧美巨波霸乳影院| 国产主播av福利精品一区| 中字幕一区二区三区乱码| 国产精品白丝喷水在线观看| 精品蜜臀av在线天堂| 在线观看无码av网站永久免费| 无码乱码av天堂一区二区| 337p日本欧洲亚洲大胆色噜噜| 国产乱人伦偷精品视频免|