在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SCAP Antibody

SCAP Antibody

  • 中文名稱：
    SCAP兔多克隆抗體
  • 貨號：
    CSB-PA020758GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    KIAA0199 antibody; SCAP antibody; SCAP_HUMAN antibody; SREBF chaperone antibody; SREBF chaperone protein antibody; SREBP cleavage activating protein antibody; SREBP cleavage-activating protein antibody; Sterol regulatory element binding protein cleavage-activating protein antibody; Sterol regulatory element-binding protein cleavage-activating protein antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human SCAP
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum. Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway. Binds cholesterol via its SSD domain.
  • 基因功能參考文獻：
    1. Polymorphism in SCAP gene is associated with high blood pressure. PMID: 28542467
    2. These insights suggest a new structural model for cholesterol-mediated regulation of Scap activity. PMID: 28377508
    3. The genetic polymorphisms of SREBF1 could play a role in the mechanism for interindividual variation of atypical antipsychotics-induced metabolic syndrome (MetS). SCAP polymorphisms with drug-induced MetS were negative in this study. PMID: 26982812
    4. this study uncovered a novel function of SCAP of counteracting the inhibitory action of Dengue Virus NS2B3 protease on STING signaling, suggesting that modulation of SCAP levels may have therapeutic implications. PMID: 28228593
    5. Data indicate that glucose-mediated glycosylation promotes SREBP cleavage-activating protein (SCAP) trafficking to the Golgi Leading to sterol regulatory element binding protein 1 (SREBP-1) activation. PMID: 26555173
    6. identified interaction of three genes in INSIG-SCAP-SREBP pathway on risk of obesity, revealing that these genes affect obesity more likely through a complex interaction pattern than single gene effect. PMID: 25028659
    7. Enhanced SCAP glycosylation by inflammation induces macrophage foam cell formation. PMID: 24146768
    8. SCAP gene polymorphisms decrease the risk of nonalcoholic fatty liver disease in females with metabolic syndrome. PMID: 24371177
    9. SREBP cleavage regulates Golgi-to-endoplasmic reticulum recycling of SREBP cleavage-activating protein (SCAP) PMID: 24478315
    10. A point mutation in Scap Loop 7 prevents interaction with Loop 1 and abolishes endoplasmic reticulum exit. PMID: 23564452
    11. the SCAP/SREBP signaling axis has a role in protecting cancer cells from lipotoxicity PMID: 23440422
    12. Data indicate that SREBP-2 and Scap are regulated by factors driving prostate growth, and suggest exploring this observation further could shed light on prostate carcinogenesis. PMID: 23454642
    13. could not identify any association between SREBF-2 1784G > C or SCAP 2386A > G SNPs and premature coronary artery disease or extent of coronary lesions in a Chinese population. PMID: 20111910
    14. TNF alpha upregulates the expression of SCAP and promotes the synthesis of triglyceride in cultured steatotic hepatocytes. PMID: 17963605
    15. Required for sterol-regulated transport of SREBPs from ER to Golgi. PMID: 12842885
    16. A possible gene-gene interaction between the genes encoding SREBP-2 and SCAP that modulate plasma lipids in a strictly gender-specific fashion. PMID: 16466730
    17. SCAP polymorphism appeared to modify the associations of SREBF-2 genotype with myocardial infarction risk among men. PMID: 17383658

    顯示更多

    收起更多

  • 亞細胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein.
  • 蛋白家族：
    WD repeat SCAP family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 30634

    OMIM: 601510

    KEGG: hsa:22937

    STRING: 9606.ENSP00000265565

    UniGene: Hs.531789



主站蜘蛛池模板： 国产手机在线国内精品| 女人被躁到高潮免费视频 | 九九线精品视频在线观看| 国产老太睡小伙子视频| 夫妻免费无码v看片| 久久99精品久久久大学生| 无码专区aaaaaa免费视频| 亚洲人成网站在线播放小说| 扒开双腿猛进入喷水高潮叫声| 国产成人高清亚洲一区妲妃 | 成人性生交大片免费看中文| 久久婷婷五月综合色丁香| 免费无码av片在线观看动漫 | 7878成人国产在线观看| 亚洲一区爱区精品无码| 国产亚洲精品资源在线26u| 农民人伦一区二区三区| 色窝窝无码一区二区三区| 熟女毛多熟妇人妻在线视频| 粗大的内捧猛烈进出看视频| 好爽又高潮了毛片免费下载| 韩国美女视频黄是免费| 中文乱码字幕视频观看网站免费 | 天天爽夜夜爽视频精品| 日欧一片内射va在线影院| 亚洲日韩中文无码久久| 无码人妻精品中文字幕不卡| 日韩国产亚洲高清在线久草 | 学生妹亚洲一区二区| 精品无码日韩一区二区三区不卡| 亚洲婷婷五月激情综合app| 国产av午夜精品一区二区三区| 久久人人爽天天玩人人妻精品| 欧美激情一区二区三区| 好男人www社区视频在线资源| 国产高清在线精品一区二区三区| 欧美极品少妇×xxxbbb| 欧美熟妇性开放| 亚洲乱亚洲乱妇无码麻豆| 天天躁日日躁aaaaxxxx| 亚洲国产精品无码久久久久高潮 |