在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

HLA-DPA1

HLA class II histocompatibility antigen, DP alpha 1 chain is a protein in humans that is encoded by HLA-DPA1 gene. Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

HLA-DPA1 Antibodies

HLA-DPA1 for Homo sapiens (Human)

HLA-DPA1 Proteins

HLA-DPA1 Proteins for Homo sapiens (Human)



主站蜘蛛池模板: 九九re6热在线视频精品66| 国产亚洲熟妇在线视频| 亚洲综合无码一区二区三区不卡| 免费乱码人妻系列无码专区| 国模小黎自慰gogo人体| 色一情一乱一伦一区二区三区 | 亚洲乱码av一区二区| 国产边摸边吃奶边叫做激情视频| 女人被强╳到高潮喷水在线观看| 国产精品毛片a∨一区二区三区| av狼友无码国产在线观看| 无码人妻一区、二区、三区免费视频| 国产女人18毛片水真多18精品 | 午夜亚洲国产理论片中文飘花| 亚洲精品揄拍自拍首页一| 久久无码人妻一区二区三区| 激情偷乱人成视频在线观看| 精品免费国产一区二区| 国产免费观看久久黄av片| 国产熟妇与子伦hd| 国产高潮抽搐喷水高清| 日韩熟女精品一区二区三区| 国内揄拍国内精品少妇国语| 日本高清色www网站色噜噜噜| 日韩不卡1卡2卡三卡2021精品推荐 | 日韩av第一页在线播放| 国产成人欧美一区二区三区| 少妇久久久久久被弄到高潮 | 国产又a又黄又潮娇喘视频| 女人张开腿让男人桶个爽| 久久影院九九被窝爽爽| 亚洲成a人片在线观看天堂无码不卡| 久久不见久久见免费影院www| 国产丰满老熟女重口对白| 亚洲国产欧美在线看片一国产| 少妇人妻大乳在线视频| 末发育娇小性色xxxxx视频| 国产露脸精品产三级国产av| 亚洲精品国产av成拍色拍婷婷| 亚洲第一av网站| 国产99久9在线视频 | 传媒|