在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

HLA-DPA1

HLA class II histocompatibility antigen, DP alpha 1 chain is a protein in humans that is encoded by HLA-DPA1 gene. Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

HLA-DPA1 Antibodies

HLA-DPA1 for Homo sapiens (Human)

HLA-DPA1 Proteins

HLA-DPA1 Proteins for Homo sapiens (Human)



主站蜘蛛池模板: 久久精品成人无码观看不卡| 久久久久亚洲精品成人网 | 女人夜夜春精品a片| 中文字幕日韩精品有码视频| 国产成人精品综合在线观看| 中文字幕无码日韩专区| 亚洲精品无码成人片久久| 欧美人与禽z0zo牲伦交| 国产一区二区三区在线观看免费 | 麻豆视传媒精品av| 免费人成黄页在线观看国产| 午夜福利92国语| 国产熟妇高潮叫床视频播放| 黄网站色视频免费国产| 亚洲综合久久成人a片红豆| 久9热视频这里只精品18| 日本无码欧美一区精品久久 | 女人裸露免费视频无遮挡网站| 国产亚洲日韩av在线播放不卡 | 国产午夜福利精品久久2021| 久久人人爽人人爽人人片ⅴ| 白嫩无码人妻丰满熟妇啪啪区百度| 国内精品久久久久久久电影视 | 久久99精品久久久久婷婷| 亚洲欧美成人a∨观看| 人妻熟女久久久久久久| 精品人妻人人做人人爽夜夜爽| 久久婷婷色综合一区二区| 久久99精品国产自在现线小黄鸭| 蜜臀少妇人妻在线| 色狠狠色狠狠综合天天| 国产性夜夜春夜夜爽1a片| 亚洲中文有码字幕青青| 波多野结衣乳巨码无在线| 久久国产劲爆∧v内射| 欧美兽交xxxx×视频| 亚洲a∨精品一区二区三区| 国产一精品一av一免费| 色婷婷狠狠久久综合五月| 欧美老妇bbbwwbbbww| 中文字幕人妻丝袜成熟乱|