在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. HLA-DPA1 Antibody

HLA-DPA1 Antibody

  • 中文名稱：
    HLA-DPA1兔多克隆抗體
  • 貨號：
    CSB-PA009209
  • 規格：
    ￥1090
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    HLA-DPA1 antibody; HLA-DP1A antibody; HLASBHLA class II histocompatibility antigen antibody; DP alpha 1 chain antibody; DP(W3) antibody; DP(W4) antibody; HLA-SB alpha chain antibody; MHC class II DP3-alpha antibody; MHC class II DPA1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human HLA-DPα1.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.
  • 基因功能參考文獻：
    1. HLA-DPA1 and HLA-DPB1 variants can determine susceptibility or protective effect against Hepatitis B virus infection in an Indonesian population. PMID: 27051043
    2. The HLA-B*42, HLA-C*17, HLA-DPA1*03, and HLA-DPB1*105 genotypes were associated with allergic asthma and the HLA-B*48 genotype with the nonallergic phenotype. The presence of the haplotype HLA-DPA1*03 DQA*05 was associated with allergic asthma, and the presence of HLA-DPA1*03 and the absence of HLA-DQA*05 with nonallergic asthma. PMID: 28380482
    3. Single-nucleotide polymorphism in HLA-DPA1 gene is associated with sclerotic graft-versus-host disease. PMID: 27313329
    4. Single-nucleotide polymorphism in HLA-DP is associated with cervical cancer susceptibility. PMID: 26711785
    5. rs3077 in HLA-DPA1 is a significantly associated SNP associated with chronic hepatitis B virus infection and viral clearance. PMID: 24846544
    6. This resource provides population estimates of the frequencies of HLA alleles at these eight loci in the three population groups, particularly for HLA-DPA1 and HLA-DPB1 that were not assayed in HapMap. PMID: 24698974
    7. DPA1*02:01- DPB1*14:01 and DPA1*02:01- DPB1*17:01 haplotypes provide considerable protection effect against Posner-Schlossman syndrome. PMID: 25863099
    8. HLA-DP gene polymorphisms are strongly associated with chronic hepatitis B virus infection. PMID: 25449085
    9. The study suggests that HLA-DPA1/B1 loci are candidate susceptibility regions that have some marker single nucleotide polymorphisms for both chronic hepatitis C virus infection and F protein generation in the Han Chinese population. PMID: 24897020
    10. Single nucleotide polymorphisms rs3077 and rs9277378 in HLA-DPA1 and HLA-DPB1 are significantly associated with protective effects against chronic hepatitis B. PMID: 24465836
    11. It related to persistence of hepatitis B virus (HBV) infection and viral load in chronic HBV. PMID: 23980639
    12. HLA-DPA1 and DPB1 allele frequencies and haplotypes of the population of Guadeloupe were most similar to African populations, with characteristic alleles and haplotypes that bespeaks the admixture with other ethnicities. PMID: 24405442
    13. Crystal structure of the extracellular region of the HLA-DPA1/DPB1 heterodimer, in complex with the major antigenic peptide from the Japanese cedar pollen allergen. PMID: 25020231
    14. Data indicate that CD4+ T cell allorecognition of HLA-DP is significantly affected by DPA1 polymorphism. PMID: 24462895
    15. Studied three HLA-DP and IL28B SNPs of CHB patients with and without spontaneous HBsAg seroclearance.Haplotype analysis of HLA-DP polymorphisms showed association with HBsAg seroclearance. PMID: 23449268
    16. HLA-DP SNPs rs3077, rs9277378 and rs3128917 were associated with chronicity of HBV disease in the Chinese PMID: 23825586
    17. HLA-DP polymorphisms affect affect genotype B hepatitis B virus clearance, regulate immune selection of viral mutations, and influence cirrhosis and hepatocellular carcinoma risks contributed by hepatitis B virus mutations PMID: 24006435
    18. This is the first study that confirms the association of HLA markers and haplotypes around HLA-DPA1 and HLA-DPB1 with ankylosing spondylitis. PMID: 23459078
    19. Data indicate that comparing to GG haplotype of rs3077 (near HLA-DPA1 region) and rs9277535 (near HLA-DPB1 region), GA haplotype had a higher chance of achieving spontaneous HBsAg loss. PMID: 23326374
    20. Significant associations of HLA-DP rs3077 and rs9277535 with increased risks of cervical cancer in a Chinese population were found. PMID: 23428460
    21. HLA-DPA1 genetic variation, proxies for early life immune modulation and childhood acute lymphoblastic leukemia. PMID: 22923493
    22. HLA-DP has a role in protection against chronic hepatitis B and viral clearance in Japanese and Koreans PMID: 22737229
    23. HLA-DPA1 variant is associated with hepatitis B virus infection. PMID: 22448225
    24. A novel variant in the HLA-DPB1 3'UTR region, 496A/G, is associated significantly with HBV recovery in European and African-American populations. PMID: 22496224
    25. Genetic variants of the HLA-DP genes are risk factors for the development of hepatocellular carcinoma in chinese patients. PMID: 22105689
    26. variants previously associated with chronic hepatitis B are also strongly associated with mRNA expression of HLA-DPA1 and HLA-DPB1, suggesting that expression of these genes is important in control of HBV. PMID: 21346778
    27. genetic variants in the HLA-DPA1 and HLA-DPB1 locus are associated with the risk of pediatric asthma in Asian populations. PMID: 21814517
    28. HLA - DPA1 rs3077 T was strongly associated with decreased risk of chronic hepatitis B virus infection (odds ratio, .62; P = .001), consistent with the previous report. PMID: 21402545
    29. Genetic variants in the HLA-DP locus are strongly associated with persistent chronic hepatitis B virus infection in the Han Chinese population. PMID: 21274863
    30. DPA1*020107 was identified from a woman of Ugandan origin by a taxonomy-based sequence analysis of human leukocyte antigen DPA1. It is identical to DPA1*020101 with the exception of a single nucleotide synonymous substitution at codon 58 (GGC-->GGT). PMID: 20470845
    31. HLA-DPA1 allelic and haplotypic diversity contributes significantly to the risk for type 1 diabetes PMID: 20424227
    32. HLA-DPA1 promoter haplotypes are differently distributed in southern Chinese ethnic groups PMID: 15713216
    33. Our findings show that genetic variants in the HLA-DPA1 locus are strongly associated with risk of persistent infection with hepatitis B virus. PMID: 19349983

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
  • 蛋白家族：
    MHC class II family
  • 數據庫鏈接：

    HGNC: 4938

    OMIM: 142880

    KEGG: hsa:3113

    STRING: 9606.ENSP00000393566

    UniGene: Hs.347270



主站蜘蛛池模板： 日韩精品无码专区免费视频| 亚洲国产成人久久一区www| 日韩精品毛片无码一区到三区| 午夜婷婷精品午夜无码a片影院 | 国产精品乱码一区二区三区 | 亚洲精品午夜理伦不卡在线观看| 秋霞国产精品一区二区| 亚洲国产无套无码av电影| 后入内射国产一区二区| 996久久国产精品线观看| 午夜无码福利伦利理免| 伊人久久大香线蕉无码不卡| 亚洲欧美日韩精品久久| 乱人伦中文视频在线 | 欧美深度肠交惨叫| 精品人妻无码区在线视频| 久久久久久无码日韩欧美| 亚洲va综合va国产产va中| 在线播放免费人成视频在线观看| 国产日产欧产美| 国产精品三级av及在线观看| 无码日韩精品一区二区免费暖暖 | 久久精品中文字幕大胸| 午夜无码性爽快影院6080| 日韩成人av无码一区二区三区| 人人妻人人澡人人爽人人精品电影 | 成av人电影在线观看| 国产av毛片亚洲含羞草社| 国产精品免费看久久久无码| 天天综合天天做天天综合| 亚洲色大网站www永久网站| 又大又粗又长的高潮视频| 亚洲a∨无码无在线观看| 日本午夜免费啪视频在线| 亚洲国产欧美在线成人app| 国产亚洲产品影市在线产品| 无码人妻精品一区二区三区东京热 | 好男人社区www在线观看| 国产精品久久久久久无码| 大香线蕉伊人精品超碰| 国产产在线精品亚洲aavv |