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  4. TCTN1 Antibody

TCTN1 Antibody

  • 中文名稱：
    TCTN1兔多克隆抗體
  • 貨號：
    CSB-PA023338GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    TCTN1
  • 別名：
    JBTS13 antibody; TCTN1 antibody; TECT1 antibody; TECT1_HUMAN antibody; Tectonic family member 1 antibody; Tectonic-1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human TCTN1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IF
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Regulator of Hedgehog (Hh), required for both activation and inhibition of the Hh pathway in the patterning of the neural tube. During neural tube development, it is required for formation of the most ventral cell types and for full Hh pathway activation. Functions in Hh signal transduction to fully activate the pathway in the presence of high Hh levels and to repress the pathway in the absence of Hh signals. Modulates Hh signal transduction downstream of SMO and RAB23.
  • 基因功能參考文獻：
    1. we describe the phenotype of a patient with Varadi syndrome who is homozygous for a previously reported mutation in TCTN1 (NM_001082538.2:c.342-2A>G, p.Gly115Lysfs*8) and suggest that allelic disorders linked to TCTN1 include Varadi syndrome, in addition to Joubert syndrome and Meckel-Gruber syndrome. PMID: 28631893
    2. Flow cytometry analysis showed that depletion of TCTN1 could cause cell cycle arrest at the G2/M phase. This indicates that TCTN1 may be crucial for CRC cell growth. PMID: 28123172
    3. High TCTN1 expression is associated with Pancreatic Cancer. PMID: 26844847
    4. These findings confirmed the direct association between the TCTN1 gene and prostate cancer growth in vitro. PMID: 26310786
    5. These data suggest TCTN1 is essential for glioma cell viability, and dysregulation of TCTN1 may play a key role in glioma tumorigenesis. PMID: 25737023
    6. TCTN1 may serve as a novel prognostic factor and a potential therapeutic target for glioblastoma. PMID: 25304031
    7. Mutations in Tctn1 is associated with ciliopathies. PMID: 21725307

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  • 相關疾病：
    Joubert syndrome 13 (JBTS13)
  • 亞細胞定位：
    Cytoplasm, cytoskeleton, cilium basal body. Secreted.
  • 蛋白家族：
    Tectonic family
  • 數據庫鏈接：

    HGNC: 26113

    OMIM: 609863

    KEGG: hsa:79600

    STRING: 9606.ENSP00000380779

    UniGene: Hs.211511



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