在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CFHR5 Antibody, FITC conjugated

  • 中文名稱:
    CFHR5兔多克隆抗體, FITC偶聯(lián)
  • 貨號:
    CSB-PA883624LC01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) CFHR5 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    CFHR5
  • 別名:
    CFHL5 antibody; CFHR5 antibody; CFHR5D antibody; Complement factor H-related 5 antibody; Complement factor H-related protein 5 antibody; factor H-related gene 5 antibody; factor H-related protein 5 antibody; FHR-5 antibody; FHR5 antibody; FHR5_HUMAN antibody; FLJ10549 antibody; MGC133240 antibody; OTTHUMP00000034672 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Complement factor H-related protein 5 protein (374-569AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH.
  • 基因功能參考文獻(xiàn):
    1. Novel genetic rearrangement generated from a heterozygous deletion spanning 146 Kbp involving multiple CFHR genes leading to a CFHR1-R5 hybrid protein. This deletion was found in four family members presenting with a familial dominant glomerulopathy. PMID: 28729035
    2. Higher serum FHR-5 levels were associated with a lack of response to immunosuppression, the presence of endocapillary hypercellularity, and histology scores of IgA nephropathy severity. PMID: 28673452
    3. Our study found that rare variants in CFHR5 may contribute to the genetic susceptibility to IgA Nephropathy, which suggests that CFHR5 is an IgA Nephropathy susceptibility gene PMID: 26825529
    4. Next-generation sequencing of the CFH region identified putatively functional variants (missense, splice site and indel) on the four common haplotypes. We found no expression of any of the five CFH-related genes in the retina or RPE/Choroid/Sclera, in contrast to the liver, which is the main source of the circulating proteins. [CFHR5] PMID: 27196323
    5. Studies indicate that complement factor H-related proteins (FHR1-5) may enhance complement activation, with important implications for the role of these proteins in disease. PMID: 25979655
    6. In this study, we identify pentraxin 3 (PTX3) as a novel ligand of CFHR5 PMID: 25855355
    7. At least two distinct intronic breakpoints within the CFHR5 gene can cause the same mutant CFHR5 protein and C3 glomerulopathy. PMID: 24067434
    8. A hybrid CFHR2-CFHR5 plasma protein, arising from a chromosomal deletion mutation stabilizes the C3 convertase and reduces factor H-mediated convertase decay. PMID: 24334459
    9. Recent investigations in London and Cyprus culminated in the identification of another autosomal dominant condition that presents with microscopic haematuria because of heterozygous mutations in the CFHR5 gene--{review} PMID: 23402027
    10. A potentially pathogenic sequence variation was found in CFHR5 in the patients with atypical hemolytic uremic syndrome. PMID: 22622361
    11. CFHR5 nephropathy is discussed. PMID: 22065842
    12. Describe the clinical course, significant variable expressivity, and marked gender difference regarding the development of chronic renal failure in familial C3 glomerulopathy associated with CFHR5 mutations. PMID: 21566112
    13. evidence for an inherited renal disease, endemic in Cyprus, characterised by microscopic and synpharyngitic macroscopic haematuria, renal failure and C3 glomerulonephritis; affected individuals have an internal duplication within the gene for CFHR5 PMID: 20800271
    14. Study identified novel mutations in CFH, CFHR5, CFI, CFB and C3 in American patients with atypical hemolytic uremic syndrome. PMID: 20513133
    15. Maps to between FHR-2 and the non-complement protein factor XIIIb at 1q32. PMID: 12041828
    16. FHR-5 shares properties of binding heparin and C-reactive protein and lipoprotein association with one or more of the other FHRs, but is unique among this family of proteins in possessing independent complement-regulatory activity. PMID: 15879123
    17. Identification of specific variants of variants of CFHR5 in membranoproliferative glomerulonephritis type II. PMID: 16299065
    18. CFHR5 genetic alterations may play a secondary role in the pathogenesis of haemolytic uraemic syndrome. PMID: 17000000
    19. No definitive pathogenic CFHR5 mutations have been found in any of 639 unrelated patients with age-related macular degeneration (AMD), indicating that sequence variations in CFHR5 do not play a major role in determining AMD susceptibility. PMID: 19365580

    顯示更多

    收起更多

  • 相關(guān)疾病:
    CFHR5 deficiency (CFHR5D)
  • 亞細(xì)胞定位:
    Secreted.
  • 組織特異性:
    Expressed by the liver and secreted in plasma.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 24668

    OMIM: 608593

    KEGG: hsa:81494

    STRING: 9606.ENSP00000256785

    UniGene: Hs.282594



主站蜘蛛池模板: 69sex久久精品国产麻豆| 久久久精品94久久精品| 人妻互换一二三区激情视频| 国产精品爱久久久久久久| 日本又色又爽又黄的视频免| 中文字幕丰满乱子无码视频| 波多野结衣乳巨码无在线| 少妇人妻互换不带套| 亚洲一区二区无码偷拍| 亚洲精品国产一区二区在线观看| 无码精品国产va在线观看| 亚洲熟妇色自偷自拍另类| 玩弄漂亮少妇高潮白浆| av无码午夜福利一区二区三区| 欧美顶级少妇做爰hd| 国产精品日韩av在线播放| 四虎亚洲精品无码| 在线天堂最新版资源| 成人无码亚洲精品无码| 熟妇与小伙子matur老熟妇e| 蜜臀亚洲精品国产aⅴ综合第一| 国产成人亚洲精品无码车a| 日本黄页网站免费大全| 激情综合五月| 人人狠狠综合久久88成人| 国语自产拍无码精品视频在线 | 国产精品美女久久久久久久久 | 欧美成人免费一区二区| 亚洲色大成网站www永久一区| 曰的好深好爽免费视频网站 | 久久综合九色综合97婷婷| 无码av无码天堂资源网影音先锋 | 国产av无码精品色午夜| 亚洲成av人无码综合在线观看 | 午夜毛片不卡高清免费看| 国模无码大尺度一区二区三区| 暖暖 免费 高清 日本 在线| 激情无码人妻又粗又大中国人 | 亚洲中文字幕丝祙制服| 欧美天天拍在线视频| 成人午夜高潮免费视频|