在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CFHR5 Antibody, HRP conjugated

  • 中文名稱:
    CFHR5兔多克隆抗體, HRP偶聯(lián)
  • 貨號:
    CSB-PA883624LB01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) CFHR5 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    CFHR5
  • 別名:
    CFHL5 antibody; CFHR5 antibody; CFHR5D antibody; Complement factor H-related 5 antibody; Complement factor H-related protein 5 antibody; factor H-related gene 5 antibody; factor H-related protein 5 antibody; FHR-5 antibody; FHR5 antibody; FHR5_HUMAN antibody; FLJ10549 antibody; MGC133240 antibody; OTTHUMP00000034672 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Complement factor H-related protein 5 protein (374-569AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能:
    Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH.
  • 基因功能參考文獻(xiàn):
    1. Novel genetic rearrangement generated from a heterozygous deletion spanning 146 Kbp involving multiple CFHR genes leading to a CFHR1-R5 hybrid protein. This deletion was found in four family members presenting with a familial dominant glomerulopathy. PMID: 28729035
    2. Higher serum FHR-5 levels were associated with a lack of response to immunosuppression, the presence of endocapillary hypercellularity, and histology scores of IgA nephropathy severity. PMID: 28673452
    3. Our study found that rare variants in CFHR5 may contribute to the genetic susceptibility to IgA Nephropathy, which suggests that CFHR5 is an IgA Nephropathy susceptibility gene PMID: 26825529
    4. Next-generation sequencing of the CFH region identified putatively functional variants (missense, splice site and indel) on the four common haplotypes. We found no expression of any of the five CFH-related genes in the retina or RPE/Choroid/Sclera, in contrast to the liver, which is the main source of the circulating proteins. [CFHR5] PMID: 27196323
    5. Studies indicate that complement factor H-related proteins (FHR1-5) may enhance complement activation, with important implications for the role of these proteins in disease. PMID: 25979655
    6. In this study, we identify pentraxin 3 (PTX3) as a novel ligand of CFHR5 PMID: 25855355
    7. At least two distinct intronic breakpoints within the CFHR5 gene can cause the same mutant CFHR5 protein and C3 glomerulopathy. PMID: 24067434
    8. A hybrid CFHR2-CFHR5 plasma protein, arising from a chromosomal deletion mutation stabilizes the C3 convertase and reduces factor H-mediated convertase decay. PMID: 24334459
    9. Recent investigations in London and Cyprus culminated in the identification of another autosomal dominant condition that presents with microscopic haematuria because of heterozygous mutations in the CFHR5 gene--{review} PMID: 23402027
    10. A potentially pathogenic sequence variation was found in CFHR5 in the patients with atypical hemolytic uremic syndrome. PMID: 22622361
    11. CFHR5 nephropathy is discussed. PMID: 22065842
    12. Describe the clinical course, significant variable expressivity, and marked gender difference regarding the development of chronic renal failure in familial C3 glomerulopathy associated with CFHR5 mutations. PMID: 21566112
    13. evidence for an inherited renal disease, endemic in Cyprus, characterised by microscopic and synpharyngitic macroscopic haematuria, renal failure and C3 glomerulonephritis; affected individuals have an internal duplication within the gene for CFHR5 PMID: 20800271
    14. Study identified novel mutations in CFH, CFHR5, CFI, CFB and C3 in American patients with atypical hemolytic uremic syndrome. PMID: 20513133
    15. Maps to between FHR-2 and the non-complement protein factor XIIIb at 1q32. PMID: 12041828
    16. FHR-5 shares properties of binding heparin and C-reactive protein and lipoprotein association with one or more of the other FHRs, but is unique among this family of proteins in possessing independent complement-regulatory activity. PMID: 15879123
    17. Identification of specific variants of variants of CFHR5 in membranoproliferative glomerulonephritis type II. PMID: 16299065
    18. CFHR5 genetic alterations may play a secondary role in the pathogenesis of haemolytic uraemic syndrome. PMID: 17000000
    19. No definitive pathogenic CFHR5 mutations have been found in any of 639 unrelated patients with age-related macular degeneration (AMD), indicating that sequence variations in CFHR5 do not play a major role in determining AMD susceptibility. PMID: 19365580

    顯示更多

    收起更多

  • 相關(guān)疾病:
    CFHR5 deficiency (CFHR5D)
  • 亞細(xì)胞定位:
    Secreted.
  • 組織特異性:
    Expressed by the liver and secreted in plasma.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 24668

    OMIM: 608593

    KEGG: hsa:81494

    STRING: 9606.ENSP00000256785

    UniGene: Hs.282594



主站蜘蛛池模板: 激情综合五月丁香亚洲| 肥白大屁股bbwbbwhd| 精品爆乳一区二区三区无码av| av无码av天天av天天爽| 中文字幕精品视频在线看免费| 亚洲自偷自偷图片| 精品少妇一区二区三区免费观| 深夜爽爽动态图无遮无挡| 四虎影视88aa久久人妻| 国产一区二区三区乱码在线观看| 中文字幕亚洲码在线观看| 四虎影视884a精品国产| 日韩人妻中文无码一区二区七区| 中文字幕亚洲综合久久菠萝蜜| 中日韩va无码中文字幕| 亚洲aⅴ永久无码一区二区三区| 国产午夜伦鲁鲁| 国产欧美一区二区精品久久久| 777米奇色狠狠俺去啦奇米77| 中文字幕无码日韩欧免费软件| 午夜精品久久久久久久爽| 情侣做性视频在线播放| 无码加勒比一区二区三区四区| 亚洲乱码av中文一区二区软件| 最新高清中文字幕免费mv| 免费国产又色又爽又黄的网站| 成人毛片18女人毛片免费| 亚洲精品无码成人av电影网| 成人无码a片一区二区三区免| 午夜裸体性播放| 男男啪啪激烈高潮cc漫画免费| 精品国产一区二区三区免费| 香蕉eeww99国产精选免费| 午夜成人无码片在线观看影院| 国产嫖妓风韵犹存对白| 呦系列视频一区二区三区| 国产欧美一区二区精品久久久| 国产亚洲综合区成人国产系列| 久久99er6热线精品首页| 午夜福利电影网站鲁片大全| 狠狠色噜噜狠狠狠狠色综合久|