在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Protein cereblon (Crbn)

  • 中文名稱:
    Recombinant Mouse Protein cereblon(Crbn)
  • 品名簡稱:
    Recombinant Mouse Crbn protein
  • 貨號:
    CSB-YP806030MO
  • 說明書:
  • 規格:
    ¥1836
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
  • Uniprot No.:
  • 別名:
    CrbnProtein cereblon; Protein PiL
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full Length
  • 來源:
    Yeast
  • 分子量:
    54.9kDa
  • 表達區域:
    1-445aa
  • 氨基酸序列
    MAGEGDQQDAAHNMGNHLPLLPADSEDEDDEIEMEVEDQDSKEARKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPEVLMILIPGQTLPLQLSHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQEFGIEVVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQVFPSKPISWEDQYSCKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPENPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKASNLNLIGRPSTVHSWFPGYAWTIAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPETEDEISPDKVILCL
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2 (Probable). Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. Maintains presynaptic glutamate release and consequently, cognitive functions such as memory and learning, by negatively regulating large-conductance calcium-activated potassium (BK) channels in excitatory neurons. Likely to function by regulating the assembly and neuronal surface expression of BK channels via its interaction with KCNT1. May also be involved in regulating anxiety-like behaviors via a BK channel-independent mechanism.
  • 基因功能參考文獻:
    1. Collectively, our data suggested that CRBN is a potential treatment option against diabetes-induced osteolytic bone disease. PMID: 29353038
    2. Data show that cereblon (CRBN) limits CD4(+) T-cell activation via epigenetic regulation of Kv1.3 potassium channel (Kv1.3) expression. PMID: 27439875
    3. CRBN negatively regulates TLR4 signaling via attenuation of TRAF6 and TAB2 ubiquitination. PMID: 27468689
    4. CRBN is involved in the activation of PERK and the Ire1 pathway of the unfolded protein response.CRBN plays a role in cellular stress signaling, including the unfolded protein response, by controlling the activity of AMPK. PMID: 25619137
    5. results of this study suggest a plausible mechanism for CRBN involvement in higher brain function in humans, and they may help explain how a specific mutation in CRBN can affect the cognitive ability of patients PMID: 24993823
    6. Found significantly smaller infarct sizes and less fibrosis in the hearts of CRBN KO mice than in those of WT mice. Apoptosis was also significantly reduced in the KO mice compared with that in WT mice. PMID: 24755080
    7. findings suggest that crbn-/- mice exhibit selective HPC-dependent deficits in associative learning. PMID: 21995942
    8. CRBN directly interacts with the alpha1 subunit of AMP-activated protein kinase (AMPK alpha1) and inhibits the activation of AMPK activation. PMID: 21232561
    9. These results imply that Nrf2 stimulates CRBN gene transcription under hypoxia-reoxygenation conditions in neuronal cells. PMID: 20691658

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus. Membrane; Peripheral membrane protein.
  • 蛋白家族:
    CRBN family
  • 組織特異性:
    Highly expressed in brain.
  • 數據庫鏈接:


主站蜘蛛池模板: 中文字幕人妻熟女在线| 免费人成网站视频在线观看| 强伦人妻一区二区三区视频18| 一二三四视频社区3在线高清| 国产男女免费完整视频在线| 激情内射亚洲一区二区三区| 欧美人与动牲交a精品| 老子午夜精品无码| 亚洲中文字幕无码永久| 97性无码区免费| av天堂亚洲区无码先锋影音 | 久久精品久久久久观看99水蜜桃 | 久久不见久久见免费视频7| 国产肉体ⅹxxx137大胆| 国产在线视频精品视频| 国产强伦姧在线观看无码| 中文字幕有码无码人妻av蜜桃| 久久精品a亚洲国产v高清不卡| 日本久久综合久久综合| 国产亚洲精品岁国产微拍精品| 少妇人妻无码专区在线视频 | 中文无码人妻有码人妻中文字幕| 水蜜桃色314在线观看| 无码人妻丰满熟妇精品区| 无码av免费一区二区三区四区 | 中文无码日韩欧| 一本色道无码不卡在线观看| 久久久久久久极品内射| 黄网站色成年片在线观看| 激情国产av做激情国产爱| 国产suv精品一区二区| 午夜理论片yy44880影院| 黑人尾随强伦姧人妻爽翻天| 蜜臀av片在线观看| 成人美女黄网站色大免费的| 97精品一区二区视频在线观看 | 奇米影视色777四色在线首页| 欧美多毛肥胖老妇做爰| 免费大黄网站| 在线精品亚洲一区二区| 在线亚洲中文精品第1页|