在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Protein pelota homolog (PELO)

  • 中文名稱:
    人PELO重組蛋白
  • 貨號:
    CSB-YP861124HU
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人PELO重組蛋白
  • 貨號:
    CSB-EP861124HU
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人PELO重組蛋白
  • 貨號:
    CSB-EP861124HU-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人PELO重組蛋白
  • 貨號:
    CSB-BP861124HU
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人PELO重組蛋白
  • 貨號:
    CSB-MP861124HU
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    CGI 17; CGI17; pelo; PELO_HUMAN; pelota (Drosophila) homolog ; pelota homolog ; PRO1770; Protein pelota homolog
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區(qū)域:
    1-385
  • 氨基酸序列
    MKLVRKNIEK DNAGQVTLVP EEPEDMWHTY NLVQVGDSLR ASTIRKVQTE SSTGSVGSNR VRTTLTLCVE AIDFDSQACQ LRVKGTNIQE NEYVKMGAYH TIELEPNRQF TLAKKQWDSV VLERIEQACD PAWSADVAAV VMQEGLAHIC LVTPSMTLTR AKVEVNIPRK RKGNCSQHDR ALERFYEQVV QAIQRHIHFD VVKCILVASP GFVREQFCDY LFQQAVKTDN KLLLENRSKF LQVHASSGHK YSLKEALCDP TVASRLSDTK AAGEVKALDD FYKMLQHEPD RAFYGLKQVE KANEAMAIDT LLISDELFRH QDVATRSRYV RLVDSVKENA GTVRIFSSLH VSGEQLSQLT GVAAILRFPV PELSDQEGDS SSEED
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway. In the presence of ABCE1 and HBS1L, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes. Together with HBS1L and in presence of ABCE1, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs; this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway. As part of the PINK1-regulated signaling, upon mitochondrial damage is recruited to the ribosome/mRNA-ribonucleoprotein complex associated to mitochondrial outer membrane thereby enabling the recruitment of autophagy receptors and induction of mitophagy.
  • 基因功能參考文獻:
    1. Induction of ribosome rescue factors PELO and HBS1L is required to support protein synthesis when ABCE1 levels fall in platelets, including for hemoglobin production during blood cell development. PMID: 27681415
    2. The data suggest that the decay of platelet mRNAs is slowed by the natural loss of the mRNA surveillance and ribosome rescue factor Pelota. PMID: 28213379
    3. Human Pelota compensated for Dom34 functions in quality control of nonstop mRNA in yeast. PMID: 27543824
    4. PELO is a novel regulator of HER-signalling. PMID: 23435426
    5. The non-stop decay mechanism exists in mammalian cells and involves Hbs1, Dom34, and the exosome-Ski complex. PMID: 23667253
    6. Pelota/Hbs1 induced dissociation of elongation complexes from ribosomes and release of peptidyl-tRNA, but only in the presence of ABCE1. PMID: 21448132
    7. PELO is subcellularly localized at the actin cytoskeleton, interacts with HAX1, EIF3G and SRPX proteins and that this interaction occurs at the cytoskeleton; this interaction may facilitate PELO to detect and degrade aberrant mRNAs. PMID: 20406461
    8. thrombopoietin-induced in vitro differentiation of primary human cord blood mononuclear cells into megakaryocytes, we observed rapid, progressive CpG methylation of ITGA1, but not PELO or ITGA2. PMID: 17669516

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm.
  • 蛋白家族:
    Eukaryotic release factor 1 family, Pelota subfamily
  • 組織特異性:
    Ubiquitously expressed.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 8829

    OMIM: 605757

    KEGG: hsa:53918

    STRING: 9606.ENSP00000274311

    UniGene: Hs.644352



主站蜘蛛池模板: 国产农村乱子伦精品视频| 免费很黄无遮挡的视频| 青楼妓女禁脔道具调教sm| 狠狠色丁香久久综合| 一本一道av无码中文字幕﹣百度| 国产人妻一区二区三区久| 中文在线а√在线| 亚洲制服丝袜av一区二区三区| 国产丝袜肉丝视频在线| 久久99热只有频精品8| 国产真实的和子乱拍在线观看| 久久www免费人成一看片| 人妻少妇一区二区三区| 国产亚洲人成在线播放| 国语对白做受xxxxx在| 亚洲愉拍自拍另类图片 | 亚洲日韩国产精品第一页一区| 亚洲aⅴ天堂av天堂无码麻豆| 日日摸日日添日日碰9学生露脸| 亚洲午夜理论片在线观看| 色94色欧美sute亚洲线路一 | 亚洲一区爱区精品无码| 国产精品久久久久久人妻| 国产偷人爽久久久久久老妇app| 欧美mv日韩mv国产网站app| 亚洲夜色噜噜av在线观看| 97热久久免费频精品99| 妺妺窝人体色www聚色窝| 亚洲综合av永久无码精品一区二区| 免费国产a国产片高清网站| 熟妇丰满大屁股在线播放 | 亚洲愉拍自拍欧美精品| 国产精品永久免费视频| 日韩精品一区二区av在线观看| 中文无码第3页不卡av| 久久久久高潮毛片免费全部播放 | 国内精品国语自产拍在线观看 | 大学生高潮无套内谢视频| 亚洲中文字幕日产乱码在线| 日本一道高清一区二区三区| 野花社区视频www官网|