在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PELO Antibody, FITC conjugated

PELO Antibody, FITC conjugated

  • 中文名稱：
    PELO兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA861124LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PELO Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    CGI 17 antibody; CGI17 antibody; pelo antibody; PELO_HUMAN antibody; pelota (Drosophila) homolog antibody; pelota homolog antibody; PRO1770 antibody; Protein pelota homolog antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Protein pelota homolog protein (1-385AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway. In the presence of ABCE1 and HBS1L, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes. Together with HBS1L and in presence of ABCE1, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs; this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway. As part of the PINK1-regulated signaling, upon mitochondrial damage is recruited to the ribosome/mRNA-ribonucleoprotein complex associated to mitochondrial outer membrane thereby enabling the recruitment of autophagy receptors and induction of mitophagy.
  • 基因功能參考文獻：
    1. Induction of ribosome rescue factors PELO and HBS1L is required to support protein synthesis when ABCE1 levels fall in platelets, including for hemoglobin production during blood cell development. PMID: 27681415
    2. The data suggest that the decay of platelet mRNAs is slowed by the natural loss of the mRNA surveillance and ribosome rescue factor Pelota. PMID: 28213379
    3. Human Pelota compensated for Dom34 functions in quality control of nonstop mRNA in yeast. PMID: 27543824
    4. PELO is a novel regulator of HER-signalling. PMID: 23435426
    5. The non-stop decay mechanism exists in mammalian cells and involves Hbs1, Dom34, and the exosome-Ski complex. PMID: 23667253
    6. Pelota/Hbs1 induced dissociation of elongation complexes from ribosomes and release of peptidyl-tRNA, but only in the presence of ABCE1. PMID: 21448132
    7. PELO is subcellularly localized at the actin cytoskeleton, interacts with HAX1, EIF3G and SRPX proteins and that this interaction occurs at the cytoskeleton; this interaction may facilitate PELO to detect and degrade aberrant mRNAs. PMID: 20406461
    8. thrombopoietin-induced in vitro differentiation of primary human cord blood mononuclear cells into megakaryocytes, we observed rapid, progressive CpG methylation of ITGA1, but not PELO or ITGA2. PMID: 17669516

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Eukaryotic release factor 1 family, Pelota subfamily
  • 組織特異性：
    Ubiquitously expressed.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 8829

    OMIM: 605757

    KEGG: hsa:53918

    STRING: 9606.ENSP00000274311

    UniGene: Hs.644352



主站蜘蛛池模板： 国产午夜无码片免费| 中年熟妇的大黑p| 中文字幕精品无码一区二区| 免费看无码自慰一区二区| 黑人与中国少妇xxxx视频| 久久九九久精品国产免费直播| 亚洲日本va中文字幕| 亚洲精品第一国产综合精品| 日本japanese丰满多毛| 中文字幕av免费专区| 一区二区三区视频| 大香线蕉伊人精品超碰| 欧美白人最猛性xxxxx| 中国娇小与黑人巨大交| 国产h视频在线观看| 精品婷婷色一区二区三区| 欧美精品一产区二产区| 女人被狂c躁到高潮视频| 国产suv精品一区二人妻| 欧美香蕉爽爽人人爽| 狠狠做五月深爱婷婷伊人| 最爽free性欧美人妖| 国产高清在线精品一本大道| 99热国产这里只有精品6| 人妻少妇精品无码专区app| 国产熟妇搡bbbb搡bbbb| 女人和拘做受全程看视频| 精品国产成人高清在线观看 | 欧美18精品久久久无码午夜福利| 18禁美女黄网站色大片在线| 欧美人与性动交α欧美精品| 色一情一乱一伦一视频免费看| 国产成人92精品午夜福利| 国产一卡二卡四卡无卡免费| 伦伦影院午夜理论片| 欧美不卡一卡二卡三卡| 久久亚洲欧美国产精品| 中文有码亚洲制服av片| 亚洲天堂2017无码| 久久久久影院美女国产主播| 夜夜高潮夜夜爽夜夜爱|