在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

EMR2 Antibody

  • 中文名稱:
    EMR2兔多克隆抗體
  • 貨號:
    CSB-PA009182
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of COLO cells using EMR2 Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    ADGRE2; EMR2; Adhesion G protein-coupled receptor E2; EGF-like module receptor 2; EGF-like module-containing mucin-like hormone receptor-like 2; CD antigen CD312
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from the C-terminal region of Human EMR2.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Is a regulator of mast cell degranulation.
  • 基因功能參考文獻:
    1. miR-99a reveals two novel targets E2F2 and EMR2 that play a key role in lung tumourigenesis. By inhibiting E2F2 and EMR2, miR-99a represses in vivo the transition of epithelial cells through an EMT process concomitantly with the inhibition of stemness features and consequently decreasing the CSC population. PMID: 29072692
    2. EMR2 expression levels correlated with CTP scores and increased further in cirrhotic patients with infections. These high EMR2-expressed neutrophils had activated phenotype but with deranged functions. Higher levels of these EMR2-expressed neutrophils correlated with infectious complications and predict mortality. PMID: 27905560
    3. Data suggest that blood neutrophils expressing CD11c antigen and EMR2 protein be considered as potential biomarkers for sepsis and systemic inflammatory response syndrome (SIRS), respectively. PMID: 26153037
    4. We identified a previously unknown missense substitution in ADGRE2 which was predicted to result in the replacement of cysteine with tyrosine as the only nonsynonymous variant cosegregating with vibratory urticaria in two large kindreds. PMID: 26841242
    5. Using the myeloid cell-restricted EMR2 receptor as a paradigm, we exam the mechanistic relevance of the subunit interaction and demonstrate a critical role for autoproteolysis in mediating receptor signaling and cell activation PMID: 22310662
    6. a functional role for EMR2 in the modulation of neutrophil activation during inflammation. PMID: 22035891
    7. High EMR2 is associated with invasive phenotype in glioblastoma. PMID: 21503828
    8. The association of improved patient survival with higher nuclear expression levels identifies EMR2 as a potential biomarker in patients with invasive breast cancer. PMID: 21174063
    9. complex cellular expression programmes rather than activation modes regulate the expression of EGF-TM7 receptors in macrophages PMID: 20167235
    10. epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans PMID: 12829604
    11. role of the extracellular stalk and the G protein-coupled receptor proteolysis site motif in EMR2 processing PMID: 12860403
    12. Site-directed mutagenesis of the P(+1) cleavage site (Ser(518)) shows an absolute requirement of a Ser, Thr, or Cys residue for efficient proteolysis. PMID: 15150276
    13. The results presented here further support the idea that EMR2 plays a role in the migration and adhesion of myeloid cells during cell differentiation, maturation, and activation. PMID: 17174274
    14. Here we demonstrate how the human-restricted adhesion-GPCR EMR2 regulates neutrophil responses by potentiating the effects of a number of proinflammatory mediators and show that the transmembrane region is critical for adhesion-GPCR function. PMID: 17928360
    15. EGF-TM7 pre-mRNAs also undergo the rare trans-splicing, leading to the generation of functional chimeric receptors. PMID: 18267122

    顯示更多

    收起更多

  • 相關疾病:
    Vibratory urticaria (VBU)
  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein. Cell projection, ruffle membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 2 family, Adhesion G-protein coupled receptor (ADGR) subfamily
  • 組織特異性:
    Expression is restricted to myeloid cells. Highest expression was found in peripheral blood leukocytes, followed by spleen and lymph nodes, with intermediate to low levels in thymus, bone marrow, fetal liver, placenta, and lung, and no expression in heart
  • 數據庫鏈接:

    HGNC: 3337

    OMIM: 125630

    KEGG: hsa:30817

    STRING: 9606.ENSP00000472280

    UniGene: Hs.531619



主站蜘蛛池模板: 扒开双腿猛进入喷水高潮视频| 亚洲国产成人综合一区二区三区 | 色综合天天综合天天更新| 狠狠色狠狠色狠狠五月| 久久精晶国产99久久6| 88国产精品视频一区二区三区| 亚洲 自拍 另类小说综合图区| 男女啪啪无遮挡免费网站| 亚洲中文无码线在线观看| 久久久久亚洲精品成人网| 中文字幕亚洲无线码| 国产精品igao视频网网址| 日本高清va在线播放| 最新亚洲中文字幕在线观看| 国产伦久视频免费观看视频| 亚洲性无码av在线欣赏网| 国产成人无码av片在线观看不卡| 国产一区丝袜高跟鞋| 国产精品无码av一区二区三区| av免费不卡国产观看| 国产成a人亚洲精v品无码| 欧洲亚洲1卡二卡三卡2021| 国产亚洲精品久久一区二区| 国产人与zoxxxx另类| 国产毛a片啊久久久久久保和丸| 亚洲综合色区无码专区| 玩弄丰满熟妇xxxxx性60| 人妻熟女一区二区三区app下载 | 久久精品亚洲中文字幕无码网站| 午夜不卡久久精品无码免费 | 亚洲人成电影在线天堂色 | 亚洲精品无码久久久久秋霞| 日本污ww视频网站| 精品国产乱码久久久久久免费 | 亚洲人亚洲精品成人网站| 久久www色情成人免费| 日本少妇浓毛bbwbbwbbw| 欧美色欧美亚洲高清在线视频 | 四虎影视国产精品久久| 欧美人妻体内射射| 国产激情一区二区三区|