在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human EGF-like module-containing mucin-like hormone receptor-like 2 (EMR2), partial

Recombinant Human EGF-like module-containing mucin-like hormone receptor-like 2 (EMR2), partial

  • 中文名稱：
    Recombinant Human EGF-like module-containing mucin-like hormone receptor-like 2(EMR2),partial
  • 貨號：
    CSB-YP887050HU1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human EGF-like module-containing mucin-like hormone receptor-like 2(EMR2),partial
  • 貨號：
    CSB-EP887050HU1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human EGF-like module-containing mucin-like hormone receptor-like 2(EMR2),partial
  • 貨號：
    CSB-EP887050HU1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human EGF-like module-containing mucin-like hormone receptor-like 2(EMR2),partial
  • 貨號：
    CSB-BP887050HU1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human EGF-like module-containing mucin-like hormone receptor-like 2(EMR2),partial
  • 貨號：
    CSB-MP887050HU1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    ADGRE2; EMR2; Adhesion G protein-coupled receptor E2; EGF-like module receptor 2; EGF-like module-containing mucin-like hormone receptor-like 2; CD antigen CD312
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Is a regulator of mast cell degranulation.
  • 基因功能參考文獻：
    1. miR-99a reveals two novel targets E2F2 and EMR2 that play a key role in lung tumourigenesis. By inhibiting E2F2 and EMR2, miR-99a represses in vivo the transition of epithelial cells through an EMT process concomitantly with the inhibition of stemness features and consequently decreasing the CSC population. PMID: 29072692
    2. EMR2 expression levels correlated with CTP scores and increased further in cirrhotic patients with infections. These high EMR2-expressed neutrophils had activated phenotype but with deranged functions. Higher levels of these EMR2-expressed neutrophils correlated with infectious complications and predict mortality. PMID: 27905560
    3. Data suggest that blood neutrophils expressing CD11c antigen and EMR2 protein be considered as potential biomarkers for sepsis and systemic inflammatory response syndrome (SIRS), respectively. PMID: 26153037
    4. We identified a previously unknown missense substitution in ADGRE2 which was predicted to result in the replacement of cysteine with tyrosine as the only nonsynonymous variant cosegregating with vibratory urticaria in two large kindreds. PMID: 26841242
    5. Using the myeloid cell-restricted EMR2 receptor as a paradigm, we exam the mechanistic relevance of the subunit interaction and demonstrate a critical role for autoproteolysis in mediating receptor signaling and cell activation PMID: 22310662
    6. a functional role for EMR2 in the modulation of neutrophil activation during inflammation. PMID: 22035891
    7. High EMR2 is associated with invasive phenotype in glioblastoma. PMID: 21503828
    8. The association of improved patient survival with higher nuclear expression levels identifies EMR2 as a potential biomarker in patients with invasive breast cancer. PMID: 21174063
    9. complex cellular expression programmes rather than activation modes regulate the expression of EGF-TM7 receptors in macrophages PMID: 20167235
    10. epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans PMID: 12829604
    11. role of the extracellular stalk and the G protein-coupled receptor proteolysis site motif in EMR2 processing PMID: 12860403
    12. Site-directed mutagenesis of the P(+1) cleavage site (Ser(518)) shows an absolute requirement of a Ser, Thr, or Cys residue for efficient proteolysis. PMID: 15150276
    13. The results presented here further support the idea that EMR2 plays a role in the migration and adhesion of myeloid cells during cell differentiation, maturation, and activation. PMID: 17174274
    14. Here we demonstrate how the human-restricted adhesion-GPCR EMR2 regulates neutrophil responses by potentiating the effects of a number of proinflammatory mediators and show that the transmembrane region is critical for adhesion-GPCR function. PMID: 17928360
    15. EGF-TM7 pre-mRNAs also undergo the rare trans-splicing, leading to the generation of functional chimeric receptors. PMID: 18267122

    顯示更多

    收起更多

  • 相關疾病：
    Vibratory urticaria (VBU)
  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Cell projection, ruffle membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 2 family, Adhesion G-protein coupled receptor (ADGR) subfamily
  • 組織特異性：
    Expression is restricted to myeloid cells. Highest expression was found in peripheral blood leukocytes, followed by spleen and lymph nodes, with intermediate to low levels in thymus, bone marrow, fetal liver, placenta, and lung, and no expression in heart
  • 數據庫鏈接：

    HGNC: 3337

    OMIM: 125630

    KEGG: hsa:30817

    STRING: 9606.ENSP00000472280

    UniGene: Hs.531619



主站蜘蛛池模板： 欧美黑人大战白嫩在线| 亚洲视频高清不卡在线观看 | 亚洲色成人网站永久| 国产性夜夜春夜夜爽免费下载| 久久久久国色av免费观看性色| 国产午夜福利在线观看视频| 一本色综合网久久| 天天影视网天天综合色| 顶级欧美做受xxx000| 国产亚洲精品俞拍视频| 怡红院免费的全部视频| 欧美成人精品第一区二区三区| 亚洲午夜免费福利视频| 国内精品久久人妻无码网站 | 老子影院午夜伦手机不四虎卡| 国产精品国产三级国产专区53| 国产成人免费ā片在线观看| 国产情侣疯狂作爱系列| 国产乱子伦60女人的皮视频| 欧美老熟妇牲交| 女同性av片在线观看免费网站| 亚洲一区爱区精品无码| 欧洲av无码放荡人妇网站| 久久久久无码精品亚洲日韩| 秋霞人妻无码中文字幕| 国产精品欧美成人| 亚洲国产一区二区a毛片| 精品久久久久久久久久中文字幕| 久久久久久亚洲精品成人| 成年动漫18禁无码3d动漫| 色婷婷综合缴情综免费观看| 少妇精品无码一区二区三区| 一区二区三区四区在线 | 中国| 国产精品久久人妻互换| 真实国产乱啪福利露脸| 无码人妻一区二区三区一| 久久婷婷狠狠综合激情| 亚洲伊人成无码综合网| 国产网红主播无码精品| 久久久久久人妻毛片a片 | 亚洲国产精品无码一线岛国|