在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 試劑盒
  3. 酶聯免疫試劑盒
  4. Rat Interleukin-17F(IL17F) ELISA kit

Rat Interleukin-17F(IL17F) ELISA kit

  • 中文名稱：
    大鼠白介素17F(IL17F)酶聯免疫試劑盒
  • 貨號：
    CSB-EL011601RA
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    大鼠白介素17F(IL17F)酶聯免疫試劑盒（CSB-EL011601RA）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的IL17F含量。IL17F是重要靶點。它屬IL-17細胞因子家族，可調節免疫反應。研究發現，其參與多種炎癥和自身免疫疾病的發病機制，過度表達會引發異常免疫。目前圍繞它開發拮抗劑等藥物，以阻斷其信號傳導治療相關疾病。試劑盒檢測范圍為15.6 pg/mL-1000 pg/mL，本試劑盒適用于科研領域中對大鼠模型中IL - 17F表達水平的動態監測，如炎癥性疾病機制研究、免疫調節實驗或藥物干預效果評估等場景，為探索IL - 17F在免疫系統中的功能提供可靠工具本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    Il17fInterleukin-17F ELISA Kit; IL-17F ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    15.6 pg/mL-1000 pg/mL
  • 靈敏度：
    3.9 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of rat IL17F in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 95
    Range % 91-99
    1:2 Average % 83
    Range % 80-86
    1:4 Average % 95
    Range % 80-90
    1:8 Average % 102
    Range % 98-106
  • 回收率：
    The recovery of rat IL17F spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 87 83-90
    EDTA plasma (n=4) 104 100-108
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected
    1000 2.806 2.769 2.788 2.693
    500 2.304 2.401 2.353 2.258
    250 1.535 1.605 1.570 1.475
    125 0.680 0.698 0.689 0.594
    62.5 0.343 0.351 0.347 0.252
    31.2 0.202 0.199 0.201 0.106
    15.6 0.127 0.129 0.128 0.033
    0 0.095 0.094 0.095 　
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. IL17A-IL17F signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. IL17A-IL17F is primarily involved in host defense against extracellular bacteria and fungi by inducing neutrophilic inflammation. As signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites. Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers. IL17F homodimer can signal via IL17RC homodimeric receptor complex, triggering downstream activation of TRAF6 and NF-kappa-B signaling pathway. Via IL17RC induces transcriptional activation of IL33, a potent cytokine that stimulates group 2 innate lymphoid cells and adaptive T-helper 2 cells involved in pulmonary allergic response to fungi. Likely via IL17RC, promotes sympathetic innervation of peripheral organs by coordinating the communication between gamma-delta T cells and parenchymal cells. Stimulates sympathetic innervation of thermogenic adipose tissue by driving TGFB1 expression. Regulates the composition of intestinal microbiota and immune tolerance by inducing antimicrobial proteins that specifically control the growth of commensal Firmicutes and Bacteroidetes.
  • 基因功能參考文獻：
    1. Increased RORgammat and IL-17F levels contribute to Spontaneously Hypertensive Rat hypertension and might be therapeutic targets PMID: 28093217
    2. important mediator of increased endothelial permeability PMID: 19577259
  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    IL-17 family
  • 數據庫鏈接：


主站蜘蛛池模板： 日本成熟少妇喷浆视频| 久久精品国产福利一区二区| 久国产精品人妻aⅴ| 亚洲2020天天堂在线观看| 亚洲男人的天堂成人www| 久久精品国产久精国产| 人妻丰满被色诱中文字幕| 久久婷婷激情综合色综合俺也去 | 久久精品国产色蜜蜜麻豆 | 清纯小美女主播流白浆| 国产成人av男人的天堂| 国产成人无码视频一区二区三区| 无码av天天av天天爽| 春药玩弄少妇高潮吼叫| 亚洲五月色丁香婷婷婷| 欧美精品一区二区黄a片| 国产av无码专区国产乱码| 宅男66lu国产在线观看| 亚洲综合一区国产精品| 亚洲午夜久久久精品影院| 亚洲 小说区 图片区 都市| 国产精品自在线拍国产| 韩国 欧美 日产 国产精品| 亚洲色国产欧美日韩| 最近2019免费中文第一页| 狠狠热精品免费视频| 婷婷四房综合激情五月在线| 精品四虎国产在免费观看| 中文字幕中文乱码www| 亚洲成在人线视av| 国产精品亚洲精品日韩已满十八小| 亚洲中文字慕日产2021| 国产乱子伦精品无码码专区| 国产色视频一区二区三区| 国产超薄肉色丝袜视频| 婷婷色五月开心五月| 国产人妖xxxx做受视频| 99j久久精品久久久久久| 欧美老妇疯狂xxxxbbbb| 亚洲人成亚洲人成在线观看 | 亚洲综合另类小说色区|