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WDR41 Antibody, FITC conjugated

  • 中文名稱:
    WDR41兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA864011LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) WDR41 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    WDR41
  • 別名:
    FLJ10904 antibody; MSTP048 antibody; WD repeat domain 41 antibody; WD repeat protein 41 antibody; WD repeat-containing protein 41 antibody; WDR 41 antibody; WDR41 antibody; WDR41_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human WD repeat-containing protein 41 protein (7-284AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity.
  • 基因功能參考文獻:
    1. Study describes the identification of two binding partners for C9orf72: SMCR8 and WDR41 and demonstrated that C9orf72/SMCR8/WDR41 interacts with the FIP200/Ulk1/ATG13/ATG101 complex. PMID: 27193190
    2. The peak of association was found in and around two genes, WDR41 and PDE8B, involved in dopamine signaling and development. PMID: 21502949
  • 亞細胞定位:
    Cytoplasm.
  • 數據庫鏈接:

    HGNC: 25601

    OMIM: 617502

    KEGG: hsa:55255

    STRING: 9606.ENSP00000296679

    UniGene: Hs.482573



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