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  4. WDR41 Antibody, HRP conjugated

WDR41 Antibody, HRP conjugated

  • 中文名稱：
    WDR41兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA864011LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) WDR41 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    WDR41
  • 別名：
    FLJ10904 antibody; MSTP048 antibody; WD repeat domain 41 antibody; WD repeat protein 41 antibody; WD repeat-containing protein 41 antibody; WDR 41 antibody; WDR41 antibody; WDR41_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human WD repeat-containing protein 41 protein (7-284AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity.
  • 基因功能參考文獻：
    1. Study describes the identification of two binding partners for C9orf72: SMCR8 and WDR41 and demonstrated that C9orf72/SMCR8/WDR41 interacts with the FIP200/Ulk1/ATG13/ATG101 complex. PMID: 27193190
    2. The peak of association was found in and around two genes, WDR41 and PDE8B, involved in dopamine signaling and development. PMID: 21502949
  • 亞細胞定位：
    Cytoplasm.
  • 數據庫鏈接：

    HGNC: 25601

    OMIM: 617502

    KEGG: hsa:55255

    STRING: 9606.ENSP00000296679

    UniGene: Hs.482573



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