在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GABRE Antibody

  • 中文名稱:
    GABRE兔多克隆抗體
  • 貨號(hào):
    CSB-PA004692
  • 規(guī)格:
    ¥1090
  • 圖片:
    • Western Blot analysis of Jurkat cells using GABAA Rε Polyclonal Antibody
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    GABRE
  • 別名:
    GABA(A) receptor epsilon antibody; GABA(A) receptor subunit epsilon antibody; Gabre antibody; Gamma aminobutyric acid (GABA) A receptor epsilon antibody; Gamma aminobutyric acid receptor subunit epsilon antibody; Gamma-aminobutyric acid receptor subunit epsilon antibody; GBRE_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human GABAA Rε.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
  • 基因功能參考文獻(xiàn):
    1. This study showed that in male groups, the expression of GABRE was generally lower in schizophrenia cases compared to the control. PMID: 25660468
    2. Data indicate that GABA(A) receptor subunit epsilon (GABRE) approximately miR-452 approximately miR-224 locus is downregulated and hypermethylated in prostate cancer and is a promising epigenetic candidate biomarker for prostate cancer diagnosis and prognosis. PMID: 24737792
    3. GABRE protein levels were significantly increased in schizophrenia, major depressive disorder, and bipolar disorder patients' lateral cerebellum compared to controls. PMID: 24022508
    4. Using published alpha subunit data we identified two principal components labeled 'Decreasing' (alpha2, alpha5, beta1, gamma1 and gamma3) and 'Dynamic' (alpha1, alpha4, beta2 and gamma2) responsible for 84% of variation in GABA(A)R subunit development. PMID: 20609421
    5. Analysis of epilepsy inter-patient variability of eleven highly expressed GABAAR subunit mRNAs found seven of the subunits varied between patients, as did whole cell GABAAR currents. PMID: 15755675
    6. We report here that the GABA-activated current can be potentiated at pH 8.4 for both alphabeta and alphabeta gamma subunit-containing receptors, but only at GABA concentrations below the EC40. PMID: 15946973
    7. We infer that activation by anesthetics and GABA induces a similar conformational change at the M2 segment 6' position that is related to channel opening. PMID: 17293408
    8. Increased intracortical excitability is noted in subjects affected by the GABA A receptor gamma 2 subunit (GABRG2 Arg43Glu) mutation; findings are likely to represent an important clue to mechanisms linking this gene defect and the epilepsy phenotype. PMID: 17615250
    9. Increased expression of epsilon, in conjunction with alpha2 and beta3 subunits, results in expression of GABAA receptors with correspondingly altered rectification, deactivation and levels of spontaneous openings, but not increased total current density. PMID: 17714454
    10. Although GABRE genes did not show positive association, further studies are necessary to consider the role of other GABA receptor genes in migraine susceptibility PMID: 19087248

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Ligand-gated ion channel (TC 1.A.9) family, Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily, GABRE sub-subfamily
  • 組織特異性:
    Expressed in many tissues. Highest levels of expression in adult heart and placenta.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 4085

    OMIM: 300093

    KEGG: hsa:2564

    STRING: 9606.ENSP00000359353

    UniGene: Hs.22785



主站蜘蛛池模板: 色与欲影视天天看综合网| 国自产偷精品不卡在线| 鲁大师影院在线观看| 丰满人妻一区二区三区无码av | 中国china体内裑精亚洲日本| 双乳被一左一右吃着动态图| 色综合伊人色综合网站无码| 久久精品午夜福利| 日韩精品人妻中文字幕有码| 国产成人一区二区精品视频| 欧美自拍亚洲综合丝袜| av鲁丝一区鲁丝二区鲁丝三区| 人妻激情另类乱人伦人妻| 偷偷要色偷偷中文无码| 欧美日本亚洲韩国一区| 国内精品久久久久av福利秒拍 | 产精品视频在线观看免费 | 亚洲爆乳无码专区| 天堂а√在线中文在线新版| 久久精品成人免费国产| 亚洲kkk4444在线观看| 久久久久久夜精品精品免费啦| 草草久久久无码国产专区| 国产av无码久久精品| 女同性av片在线观看免费网站| 在教室伦流澡到高潮hgl动漫| 欧美人禽zozo动人物杂交| 欧美老熟妇牲交| 欧美午夜精品一区二区蜜桃| 色窝窝无码一区二区三区成人网站| 中文字幕一区二区三区日韩精品| 在线亚洲日产一区二区| 日本真人边吃奶边做爽免费视频| 国产内射老熟女aaaa| 亚洲精品久久久蜜桃| 成人午夜电影福利免费| 97国产一区二区三区四区久久| 无尺码精品产品网站| 色欲久久久天天天综合网| 国产亚洲综合欧美视频| 国产精品毛多多水多|