在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Gamma-aminobutyric acid receptor subunit epsilon (GABRE), partial

  • 中文名稱:
    人GABRE重組蛋白
  • 貨號:
    CSB-YP009150HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人GABRE重組蛋白
  • 貨號:
    CSB-EP009150HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人GABRE重組蛋白
  • 貨號:
    CSB-EP009150HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人GABRE重組蛋白
  • 貨號:
    CSB-BP009150HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人GABRE重組蛋白
  • 貨號:
    CSB-MP009150HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    GABRE
  • Uniprot No.:
  • 別名:
    GABA(A) receptor epsilon; GABA(A) receptor subunit epsilon; Gabre; Gamma aminobutyric acid (GABA) A receptor epsilon; Gamma aminobutyric acid receptor subunit epsilon; Gamma-aminobutyric acid receptor subunit epsilon; GBRE_HUMAN
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

相關產品

靶點詳情

  • 功能:
    GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
  • 基因功能參考文獻:
    1. This study showed that in male groups, the expression of GABRE was generally lower in schizophrenia cases compared to the control. PMID: 25660468
    2. Data indicate that GABA(A) receptor subunit epsilon (GABRE) approximately miR-452 approximately miR-224 locus is downregulated and hypermethylated in prostate cancer and is a promising epigenetic candidate biomarker for prostate cancer diagnosis and prognosis. PMID: 24737792
    3. GABRE protein levels were significantly increased in schizophrenia, major depressive disorder, and bipolar disorder patients' lateral cerebellum compared to controls. PMID: 24022508
    4. Using published alpha subunit data we identified two principal components labeled 'Decreasing' (alpha2, alpha5, beta1, gamma1 and gamma3) and 'Dynamic' (alpha1, alpha4, beta2 and gamma2) responsible for 84% of variation in GABA(A)R subunit development. PMID: 20609421
    5. Analysis of epilepsy inter-patient variability of eleven highly expressed GABAAR subunit mRNAs found seven of the subunits varied between patients, as did whole cell GABAAR currents. PMID: 15755675
    6. We report here that the GABA-activated current can be potentiated at pH 8.4 for both alphabeta and alphabeta gamma subunit-containing receptors, but only at GABA concentrations below the EC40. PMID: 15946973
    7. We infer that activation by anesthetics and GABA induces a similar conformational change at the M2 segment 6' position that is related to channel opening. PMID: 17293408
    8. Increased intracortical excitability is noted in subjects affected by the GABA A receptor gamma 2 subunit (GABRG2 Arg43Glu) mutation; findings are likely to represent an important clue to mechanisms linking this gene defect and the epilepsy phenotype. PMID: 17615250
    9. Increased expression of epsilon, in conjunction with alpha2 and beta3 subunits, results in expression of GABAA receptors with correspondingly altered rectification, deactivation and levels of spontaneous openings, but not increased total current density. PMID: 17714454
    10. Although GABRE genes did not show positive association, further studies are necessary to consider the role of other GABA receptor genes in migraine susceptibility PMID: 19087248

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Ligand-gated ion channel (TC 1.A.9) family, Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily, GABRE sub-subfamily
  • 組織特異性:
    Expressed in many tissues. Highest levels of expression in adult heart and placenta.
  • 數據庫鏈接:

    HGNC: 4085

    OMIM: 300093

    KEGG: hsa:2564

    STRING: 9606.ENSP00000359353

    UniGene: Hs.22785



主站蜘蛛池模板: 国产成人亚洲综合无码精品 | 国产精品亚洲а∨天堂网| 国产女人爽的流水毛片| 无码国产偷倩在线播放| 偷窥国产亚洲免费视频| 久天啪天天久久99久孕妇| 亚洲综合色区中文字幕| 精品一区精品二区制服| 天天天天做夜夜夜夜做无码| 草裙社区精品视频三区免费看| 99在线精品视频观看免费| 国产精品毛片无码| 久热这里只有精品视频6| 2020精品自拍视频曝光| 国产午夜福利不卡在线观看| 久久亚洲国产精品五月天婷| 少妇人妻互换不带套| 一本一道av无码中文字幕| 无码国模大尺度视频在线观看 | 国产精品久久久久久tv| 国产成人欧美一区二区三区| 人妻少妇精品无码专区动漫| 蜜桃视频网站| 国产午夜福利院757视频| 久久精品超碰av无码| 精品无码一区二区三区| 精品久久久久国产免费| 午夜精品久久久久久久四虎| 99在线精品视频高潮喷吹| 青青草原精品99久久精品66| 国产精品无码久久久久| 国产精品亚洲精品一区二区| 中文字幕va一区二区三区| 亚洲精品中文字幕乱码三区| 国产亚洲精品97在线视频一| 在线va无卡无码高清| 被灌满精子的波多野结衣| 熟妇人妻av无码一区二区三区| 国产成人精品永久免费视频| 两性色午夜视频免费无码| 国产人妻人伦精品1国产丝袜 |