在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. GPR4 Antibody, HRP conjugated

GPR4 Antibody, HRP conjugated

  • 中文名稱：
    GPR4兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA009813LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) GPR4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    GPR4; G-protein coupled receptor 4; G-protein coupled receptor 6C.l; GPR6C.l
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human G-protein coupled receptor 4 protein (285-362AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Proton-sensing G-protein coupled receptor couples to multiple intracellular signaling pathways, including GNAS/cAMP, GNAQ/phospholipase C (PLC), and GNA12/GNA13/Rho pathways. Acidosis-induced GPR4 activation increases paracellular gap formation and permeability of vascular endothelial cells through the GNA12/GNA13/Rho GTPase signaling pathway. In the brain may mediate central respiratory sensitivity to CO(2)H(+).
  • 基因功能參考文獻(xiàn)：
    1. Proton-sensing GPR4 signaling mediated the proton-induced inhibitory effects on the osteogenesis of BMSCs. YAP was the downstream effector of GPR4 signaling. Extracellular pH modulates the osteogenic responses of BMSCs by regulating the proton-sensing GPR4-YAP pathway. PMID: 27256071
    2. These results suggest that zOGR1, but not GPR4, is also a metal-sensing G-protein-coupled receptor in addition to a proton-sensing G-protein-coupled receptor, although not all metals that activate hOGR1 activated zOGR1. PMID: 28270026
    3. GPR4 blockade attenuated renal injury after IR and reduced the cell apoptosis through the suppression of CHOP expression. PMID: 29089376
    4. acidosis/GPR4-induced endoplasmic reticulum stress pathways in endothelial cells may regulate vascular growth and inflammatory response in the acidic microenvironment. PMID: 28134810
    5. it was demonstrated that GPR4 affects ECs by regulating Notch1, a function that may be important for physiological and pathological angiogenesis. PMID: 27279286
    6. GPR4 induces angiogenesis via GPR4-induced p38-mediated IL6, IL8 and VEGFA secretion at acidic extracellular pH in squamous cell carcinoma of the head and neck PMID: 27078157
    7. The results suggested that GPR4 may play an important role in the development of epithelial ovarian carcinoma (EOC), and its overexpression might be required for the angiogenesis, tumor growth, and metastasis of EOC PMID: 23888957
    8. acidosis/GPR4 signaling regulates endothelial cell adhesion mainly through the G(s)/cAMP/Epac pathway PMID: 22110680
    9. The mutation of histidine residue at 79, 165, or 269 from the N-terminal of GPR4 to phenylalanine shifted the half-maximal effective concentration (EC(50)) of proton-induced signaling activities to the right, including cAMP accumulation. PMID: 20211729
    10. Endogenous GPR4 in endothelial cells may be a potential G protein-coupled receptor by which LPC signals proinflammatory activities. PMID: 12805023
    11. GPR4, a close relative of OGR1, also responds to pH changes, but elicits cyclic AMP formation PMID: 12955148
    12. sphingosylphosphorylcholine and lysophosphatidic acid are not the ligands for GPR4 and that this receptor may constitutively inhibit ERK1/2 activation PMID: 14567679
    13. GPR4 and TDAG8 overexpression in human tumors plays a role in driving or maintaining tumor formation PMID: 15221007
    14. results identify sphingosylphosphorylcholine and its receptor, G protein-coupled receptor 4(GPR4), as critical regulators of the angiogenic potential of endothelial cells PMID: 15857892
    15. GPR4 may play a critical role in the inflammatory responses activated by lysophosphatidylcholine PMID: 16461426
    16. GPR4 in brain endothelial cells regulates monocyte transmigration. PMID: 17364894
    17. lysophosphatidylcholine receptor G protein-coupled receptor 4 (GPK4) was expressed in YPEN-1 cells and triggered the cAMP/protein kinase A/cAMP response element-binding protein pathway, resulting in upregulation of adhesion molecules. PMID: 17437524
    18. Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms. PMID: 17462861

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 4497

    OMIM: 600551

    KEGG: hsa:2828

    STRING: 9606.ENSP00000319744

    UniGene: Hs.17170



主站蜘蛛池模板： 3d动漫精品啪啪一区二区中| 国产精品成人av在线观看| 亚洲女同一区二区| 东京热无码av一区二区| 中文字幕无码中文字幕有码| 高清粉嫩无套内谢国语播放| 老汉色老汉首页a亚洲| 天堂中文在线最新版地址| 色偷偷亚洲男人本色| 亚洲欧美日韩中文无线码| 色妺妺免费影院| 亚洲日本乱码一区二区产线一∨ | 午夜影视免费x看| 国产熟妇乱xxxxx大屁股网| 97免费人妻无码视频| 无码高潮又爽又黄a片软件 | 大肉大捧一进一出好爽视频mba | 午夜在线看的免费网站| 欧美巨大黑人精品videos| 日本熟妇浓毛hdsex| 中文在线а√在线| 亚洲电影天堂av2017| 日本熟妇色xxxxx欧美老妇| 久久不见久久见免费影院www | 天堂中文在线资源| 亚洲精品国产综合久久一线| 国产日韩综合av在线观看一区| 亚洲人成网站在小说| 伊人情人综合网| 老司机导航亚洲精品导航| 亚洲人成在线观看影院牛大爷| 天天躁日日躁狠狠躁人妻 | 欧美老熟妇乱xxxxx| 成人午夜精品无码区| 国产成人综合在线女婷五月99播放| 国产+成+人+亚洲欧洲自线| 精品蜜臀久久久久99网站| 成人免费直播| 狠狠狠色丁香综合婷婷久久| 人成午夜免费视频无码| 久久久久九九精品影院|