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B4GALT5 Antibody

  • 中文名稱:
    B4GALT5兔多克隆抗體
  • 貨號:
    CSB-PA004624
  • 規(guī)格:
    ¥1090
  • 圖片:
    • Western Blot analysis of 293 cells using β-1,4-Gal-T5 Polyclonal Antibody
    • Western Blot analysis of K562 cells using β-1,4-Gal-T5 Polyclonal Antibody
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    B4GALT5
  • 別名:
    4-galactosyltransferase 5 antibody; 4-GalT II antibody; 4-GalTase 5 antibody; B4Gal T5 antibody; b4Gal-T5 antibody; B4galt5 antibody; B4GT5_HUMAN antibody; Beta 1 4 galactosyltransferase 5 antibody; Beta 1 4 galactosyltransferase V antibody; Beta 1 4 GalT II antibody; Beta 1 4 GalT IV antibody; Beta 1 4 GalTase 5 antibody; Beta-1 antibody; Beta-1,4-galactosyltransferase 5 antibody; Beta-1,4-GalT II antibody; Beta-1,4-GalTase 5 antibody; Beta4 GALT IV antibody; Beta4Gal T5 antibody; Beta4Gal-T5 antibody; Beta4GalT V antibody; gt V antibody; gtV antibody; MGC138470 antibody; UDP Gal:beta GlcNAc beta 1 4 galactosyltransferase 5 antibody; UDP Gal:betaGlcNAc beta 1 4 galactosyltransferase 5 antibody; UDP Gal:betaGlcNAc beta 1 4 galactosyltransferase polypeptide 5 antibody; UDP galactose:beta N acetylglucosamine beta 1 4 galactosyltransferase 5 antibody; UDP-Gal:beta-GlcNAc beta-1 antibody; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 5 antibody; UDP-galactose:beta-N-acetylglucosamine beta-1 antibody; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 5 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from the C-terminal region of Human β-1,4-Gal-T5.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation. Plays a role in the glycosylation of BMPR1A and regulation of its protein stability. Essential for extraembryonic development during early embryogenesis.
  • 基因功能參考文獻:
    1. 2.3-kb 5'-flanking region of the human beta-1,4-GalT V gene was cloned and the region -116/-18 relative to the transcription start site as that having promoter activity. PMID: 15263012
    2. B4GALT1 and B4GALT5, two members of B4GALT gene family, are involved in the development of multidrug resistance of human leukemia cells. PMID: 23744354
    3. The expression of the beta-1,4-GalT V gene has been shown to be regulated by transcription factors Sp1 and Ets-1 in cancer cells.(review) PMID: 22687727
    4. These data reveal a critical role of beta1,4GalT V in the self-renewal and tumorigenicity of glioma-initiating cells. PMID: 20417617
    5. Over-expression of beta-1,4-galactosyltransferase V increases the growth of astrocytoma cell line PMID: 12385586
    6. results suggest that GalT V functioned as a novel glioma growth activator and might represent a novel target in glioma therapy PMID: 16461357
    7. Ets-1 enhances expression of the beta-1,4-GalT V gene through activation of the Sp1 gene in cancer cells PMID: 17656364

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  • 亞細胞定位:
    Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Golgi apparatus.
  • 蛋白家族:
    Glycosyltransferase 7 family
  • 組織特異性:
    Ubiquitously expressed.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 928

    OMIM: 604016

    KEGG: hsa:9334

    STRING: 9606.ENSP00000360776

    UniGene: Hs.370487



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