在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PTPRZ1 Antibody

  • 中文名稱:
    PTPRZ1兔多克隆抗體
  • 貨號:
    CSB-PA019068GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    PTPRZ1
  • 別名:
    3F8 chondroitin sulfate proteoglycan antibody; 3H1 keratan sulfate proteoglycan antibody; HPTPZ antibody; HPTPzeta antibody; Phosphacan antibody; Protein tyrosine phosphatase receptor type Z polypeptide 2 antibody; Protein tyrosine phosphatase, receptor type, Z polypeptide 1 antibody; Protein tyrosine phosphatase, receptor type, zeta polypeptide 1 antibody; Protein-tyrosine phosphatase receptor type Z polypeptide 1 antibody; Protein-tyrosine phosphatase receptor type Z polypeptide 2 antibody; PTP-ZETA antibody; PTP18 antibody; PTPRZ antibody; PTPRZ_HUMAN antibody; Ptprz1 antibody; PTPZ antibody; R PTP zeta 2 antibody; R-PTP-zeta antibody; R-PTP-zeta-2 antibody; Receptor type tyrosine phosphatase beta/zeta antibody; Receptor-type tyrosine-protein phosphatase zeta antibody; RPTP-BETA antibody; RPTPB antibody; RPTPbeta antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human PTPRZ1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades.
  • 基因功能參考文獻:
    1. Authors characterized exosomes from GBM cells harbouring and not harbouring PTPRZ1-MET fusion (ZM fusion). PMID: 28504721
    2. PTPRZ1 is affected in a contiguous gene deletion syndrome PMID: 23570448
    3. Confirm contribution of PTPRZ1, and especially PTPRQ, in CRC carcinogenesis and demonstrated that PTPRQ expression is correlated with KRAS mutation. PMID: 26851024
    4. Data indicate that enhanced MET oncoprotein RNA expression by fusion with receptor-type tyrosine-protein phosphatase zeta (PTPRZ1). PMID: 25935522
    5. Data indicate that the fusion arose from translocation events involving introns 3 or 8 of protein tyrosine phosphatase, receptor-type, Z polypeptide 1 (PTPRZ1) and intron 1 of hepatocyte growth factor receptor MET. PMID: 25135958
    6. Distinct domains of PTPRZ-B are differentially required for migration and proliferation of glioma cells, respectively. PMID: 25238264
    7. Protein tyrosine phosphatase zeta enhances proliferation by increasing beta-catenin nuclear expression in VHL-inactive human renal cell carcinoma cells. PMID: 23588815
    8. Data suggest that CSF-1R-independent actions of IL-34 via receptor-type protein-tyrosine phosphatase zeta (PTP-zeta) might be considered in evaluating IL-34 roles in development and disease. PMID: 23744080
    9. PTPRZ1 was highly expressed in human neuroendocrine tumor tissues and PTPRZ1 is an oncogenic tyrosine phosphatase in small-cell lung carcinoma. PMID: 23170925
    10. Receptor-type Protein tyrosine phosphatase beta regulates met phosphorylation and function in head and neck squamous cell carcinoma. PMID: 23226095
    11. Studies indicate that RPTPzeta is an RPTP for which a link between ligand-dependent dimerization and inhibition of the intracellular tyrosine phosphatase activity has been clearly established. PMID: 22682003
    12. Enhanced RPTPbeta/zeta signaling can contribute to schizophrenia phenotypes and support both construct and face validity for PTPRZ1-transgenic mice as a model for multiple schizophrenia phenotypes. PMID: 22832403
    13. Loss of RPTPZ promotes prostate cancer metastasi. PMID: 23060448
    14. The results of this study suggested that pleiotrophin inhibition of PTPRZ1 contributes to the homeostatic self-renewal of OPCs and that this process is mediated by the tonic activation of beta-catenin/TCF-dependent transcription. PMID: 23100427
    15. report the cocrystal structure of the carbonic anhydrase-like domain of PTPRZ bound to tandem Ig repeats of CNTN1 and binding assays to show that PTPRZ binds specifically to CNTN1 expressed at the surface of oligodendrocyte precursor cells PMID: 21969550
    16. molecular basis for the substrate recognition of Ptprz. PMID: 21890632
    17. RPTP-beta is a key regulator of Met function. PMID: 21454675
    18. preferential activation of PTPRZ1 by HIF-2 results at least in part from cooperative binding of HIF-2 and ELK1 to nearby sites on the PTPRZ1 promoter region PMID: 20224786
    19. PTPRZ1 has a role in oligodendrocyte survival and in recovery from demyelinating disease PMID: 12355066
    20. RPTPzeta has a novel role in regulating glioblastoma cell motility PMID: 14555979
    21. In AZ-521 cells, which mainly express RPTPbeta, VacA, after binding to RPTPbeta in non-lipid raft microdomains on the cell surface, is localized with RPTPbeta in lipid rafts in a temperature- and VacA concentration-dependent process. PMID: 17030583
    22. Midkine, pleiotrophin (PTN), and their receptors syndecan-3 and receptor protein tyrosine phosphatase beta/zeta, were highly expressed in the striatum during developmen PMID: 17368428
    23. the PTN/RPTPbeta/zeta signaling pathway may be constitutively activated and potentially function to constitutively activate ALK in human breast cancer PMID: 17706593
    24. the effect of the shorter basic peptide P(122-131) on DU145 cells, which express HARP and its receptor RPTPB, suggested interference, under anchorage-independent conditions, of P(122-131) with a HARP autocrine loop in an RPTPB -dependent fashion. PMID: 17727841
    25. Pleiotrophin receptor (PTPRZ1) is expressed in embryonic stem cells and mediates important signals for survival, proliferation, and maintenance of pluripotency state. PMID: 17823238
    26. results from the immunohistochemical analyses of rPTPbeta/zeta expression should prompt further evaluation of this protein as a novel oligodendroglioma marker. PMID: 18003890
    27. PTPRZ1 is unlikely to be related to the development of schizophrenia in the Japanese population PMID: 18186075
    28. the cleavage sites in the extracellular juxtamembrane region of Ptprz by tumor necrosis factor-alpha converting enzyme and matrix metalloproteinase 9. PMID: 18713734
    29. GnT-Vb-mediated glycosylation of RPTPbeta promotes galectin-1 binding and RPTPbeta levels of retention on the cell surface. PMID: 18838383
    30. these data suggest that alpha(v)beta(3) is a key molecule that determines the stimulatory or inhibitory effect of pleiotrophin on cell migration. PMID: 19141530
    31. phosphacan was present in the evolving astroglial scar after human traumatic spinal cord injury, and, therefore, might play an important role in the blockade of successful CNS regeneration. PMID: 19604403

    顯示更多

    收起更多

  • 亞細胞定位:
    [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Secreted.; [Isoform 2]: Secreted.
  • 蛋白家族:
    Protein-tyrosine phosphatase family, Receptor class 5 subfamily
  • 組織特異性:
    Specifically expressed in the central nervous system, where it is localized in the Purkinje cell layer of the cerebellum, the dentate gyrus, and the subependymal layer of the anterior horn of the lateral ventricle. Developmentally regulated in the brain.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 9685

    OMIM: 176891

    KEGG: hsa:5803

    STRING: 9606.ENSP00000377047

    UniGene: Hs.489824



主站蜘蛛池模板: 人妻夜夜爽天天爽三区丁香花| 99精品无码一区二区| 亚洲欧洲日产国码久在线| 午夜在线a亚洲v天堂网2018| www亚洲精品久久久乳| 巨大乳做爰视频在线看| 97se亚洲国产综合自在线| 国产亚洲曝欧美不卡精品| 欧美丰满老熟妇aaaa片| 国产成人亚洲综合无码精品| 欧美大片va欧美在线播放| 一区二区三区鲁丝不卡麻豆| 亚洲欧美国产制服图片区| 亚洲国产另类久久久精品| 高级会所人妻互换94部分| 无码人妻久久一区二区三区| 欧洲熟妇色xxxxx视频| 尤物蜜芽国产成人精品区| 2020国产在线拍揄自揄视频| 午夜视频体内射.com.com| 亚洲s色大片在线观看| 国产ae86亚洲福利入口| 衣服被扒开强摸双乳18禁网站| 久久综合久色欧美综合狠狠| 国产精品va在线观看无码| 亚洲精品国产精品制服丝袜| 国产免费爽爽视频在线观看| 2019午夜福利不卡片在线| 日韩大片高清播放器| 日韩精品久久久久久久电影蜜臀| 人妻av中文字幕一区二区三区| 亚洲欧美综合精品二区| 日本边添边摸边做边爱| 4438xx亚洲最大五色丁香| 欧美 国产 亚洲视频| 亚洲中国最大av网站| 午夜亚洲福利在线老司机| 无码人妻一区二区三区免费看 | 久久超碰精品一夜七次郎| 99精品久久久久中文字幕| 性高朝久久久久久久久久|