在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PTPRZ1 Antibody

  • 中文名稱:
    PTPRZ1兔多克隆抗體
  • 貨號(hào):
    CSB-PA019068LA01HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA019068LA01HU at dilution of 1:100
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) PTPRZ1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PTPRZ1
  • 別名:
    3F8 chondroitin sulfate proteoglycan antibody; 3H1 keratan sulfate proteoglycan antibody; HPTPZ antibody; HPTPzeta antibody; Phosphacan antibody; Protein tyrosine phosphatase receptor type Z polypeptide 2 antibody; Protein tyrosine phosphatase, receptor type, Z polypeptide 1 antibody; Protein tyrosine phosphatase, receptor type, zeta polypeptide 1 antibody; Protein-tyrosine phosphatase receptor type Z polypeptide 1 antibody; Protein-tyrosine phosphatase receptor type Z polypeptide 2 antibody; PTP-ZETA antibody; PTP18 antibody; PTPRZ antibody; PTPRZ_HUMAN antibody; Ptprz1 antibody; PTPZ antibody; R PTP zeta 2 antibody; R-PTP-zeta antibody; R-PTP-zeta-2 antibody; Receptor type tyrosine phosphatase beta/zeta antibody; Receptor-type tyrosine-protein phosphatase zeta antibody; RPTP-BETA antibody; RPTPB antibody; RPTPbeta antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Receptor-type tyrosine-protein phosphatase zeta protein (36-300AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated

    本頁(yè)面中的產(chǎn)品,PTPRZ1 Antibody (CSB-PA019068LA01HU),的標(biāo)記方式是Non-conjugated。對(duì)于PTPRZ1 Antibody,我們還提供其他標(biāo)記。見下表:

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA019068LB01HU PTPRZ1 Antibody, HRP conjugated ELISA
    FITC CSB-PA019068LC01HU PTPRZ1 Antibody, FITC conjugated
    Biotin CSB-PA019068LD01HU PTPRZ1 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades.
  • 基因功能參考文獻(xiàn):
    1. Authors characterized exosomes from GBM cells harbouring and not harbouring PTPRZ1-MET fusion (ZM fusion). PMID: 28504721
    2. PTPRZ1 is affected in a contiguous gene deletion syndrome PMID: 23570448
    3. Confirm contribution of PTPRZ1, and especially PTPRQ, in CRC carcinogenesis and demonstrated that PTPRQ expression is correlated with KRAS mutation. PMID: 26851024
    4. Data indicate that enhanced MET oncoprotein RNA expression by fusion with receptor-type tyrosine-protein phosphatase zeta (PTPRZ1). PMID: 25935522
    5. Data indicate that the fusion arose from translocation events involving introns 3 or 8 of protein tyrosine phosphatase, receptor-type, Z polypeptide 1 (PTPRZ1) and intron 1 of hepatocyte growth factor receptor MET. PMID: 25135958
    6. Distinct domains of PTPRZ-B are differentially required for migration and proliferation of glioma cells, respectively. PMID: 25238264
    7. Protein tyrosine phosphatase zeta enhances proliferation by increasing beta-catenin nuclear expression in VHL-inactive human renal cell carcinoma cells. PMID: 23588815
    8. Data suggest that CSF-1R-independent actions of IL-34 via receptor-type protein-tyrosine phosphatase zeta (PTP-zeta) might be considered in evaluating IL-34 roles in development and disease. PMID: 23744080
    9. PTPRZ1 was highly expressed in human neuroendocrine tumor tissues and PTPRZ1 is an oncogenic tyrosine phosphatase in small-cell lung carcinoma. PMID: 23170925
    10. Receptor-type Protein tyrosine phosphatase beta regulates met phosphorylation and function in head and neck squamous cell carcinoma. PMID: 23226095
    11. Studies indicate that RPTPzeta is an RPTP for which a link between ligand-dependent dimerization and inhibition of the intracellular tyrosine phosphatase activity has been clearly established. PMID: 22682003
    12. Enhanced RPTPbeta/zeta signaling can contribute to schizophrenia phenotypes and support both construct and face validity for PTPRZ1-transgenic mice as a model for multiple schizophrenia phenotypes. PMID: 22832403
    13. Loss of RPTPZ promotes prostate cancer metastasi. PMID: 23060448
    14. The results of this study suggested that pleiotrophin inhibition of PTPRZ1 contributes to the homeostatic self-renewal of OPCs and that this process is mediated by the tonic activation of beta-catenin/TCF-dependent transcription. PMID: 23100427
    15. report the cocrystal structure of the carbonic anhydrase-like domain of PTPRZ bound to tandem Ig repeats of CNTN1 and binding assays to show that PTPRZ binds specifically to CNTN1 expressed at the surface of oligodendrocyte precursor cells PMID: 21969550
    16. molecular basis for the substrate recognition of Ptprz. PMID: 21890632
    17. RPTP-beta is a key regulator of Met function. PMID: 21454675
    18. preferential activation of PTPRZ1 by HIF-2 results at least in part from cooperative binding of HIF-2 and ELK1 to nearby sites on the PTPRZ1 promoter region PMID: 20224786
    19. PTPRZ1 has a role in oligodendrocyte survival and in recovery from demyelinating disease PMID: 12355066
    20. RPTPzeta has a novel role in regulating glioblastoma cell motility PMID: 14555979
    21. In AZ-521 cells, which mainly express RPTPbeta, VacA, after binding to RPTPbeta in non-lipid raft microdomains on the cell surface, is localized with RPTPbeta in lipid rafts in a temperature- and VacA concentration-dependent process. PMID: 17030583
    22. Midkine, pleiotrophin (PTN), and their receptors syndecan-3 and receptor protein tyrosine phosphatase beta/zeta, were highly expressed in the striatum during developmen PMID: 17368428
    23. the PTN/RPTPbeta/zeta signaling pathway may be constitutively activated and potentially function to constitutively activate ALK in human breast cancer PMID: 17706593
    24. the effect of the shorter basic peptide P(122-131) on DU145 cells, which express HARP and its receptor RPTPB, suggested interference, under anchorage-independent conditions, of P(122-131) with a HARP autocrine loop in an RPTPB -dependent fashion. PMID: 17727841
    25. Pleiotrophin receptor (PTPRZ1) is expressed in embryonic stem cells and mediates important signals for survival, proliferation, and maintenance of pluripotency state. PMID: 17823238
    26. results from the immunohistochemical analyses of rPTPbeta/zeta expression should prompt further evaluation of this protein as a novel oligodendroglioma marker. PMID: 18003890
    27. PTPRZ1 is unlikely to be related to the development of schizophrenia in the Japanese population PMID: 18186075
    28. the cleavage sites in the extracellular juxtamembrane region of Ptprz by tumor necrosis factor-alpha converting enzyme and matrix metalloproteinase 9. PMID: 18713734
    29. GnT-Vb-mediated glycosylation of RPTPbeta promotes galectin-1 binding and RPTPbeta levels of retention on the cell surface. PMID: 18838383
    30. these data suggest that alpha(v)beta(3) is a key molecule that determines the stimulatory or inhibitory effect of pleiotrophin on cell migration. PMID: 19141530
    31. phosphacan was present in the evolving astroglial scar after human traumatic spinal cord injury, and, therefore, might play an important role in the blockade of successful CNS regeneration. PMID: 19604403

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Secreted.; [Isoform 2]: Secreted.
  • 蛋白家族:
    Protein-tyrosine phosphatase family, Receptor class 5 subfamily
  • 組織特異性:
    Specifically expressed in the central nervous system, where it is localized in the Purkinje cell layer of the cerebellum, the dentate gyrus, and the subependymal layer of the anterior horn of the lateral ventricle. Developmentally regulated in the brain.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 9685

    OMIM: 176891

    KEGG: hsa:5803

    STRING: 9606.ENSP00000377047

    UniGene: Hs.489824



主站蜘蛛池模板: 狠狠色噜噜狠狠狠狠97首创麻豆| 人成午夜免费视频无码| 最近2019免费中文第一页| 九一九色国产| 亚洲夜色噜噜av在线观看| 国产成人av无码永久免费一线天| 在线中文字幕亚洲日韩2020| a片免费视频在线观看| 国产亚洲精品久久久久久打不开| 国产精品卡1卡2卡3网站| 亚洲欧美不卡视频在线播放| 99久久婷婷国产综合精品青草免费 | 亚洲中文字幕无码av在线| 99国产精品久久久久久久日本竹 | 国产精品h片在线播放| 最近免费中文字幕中文高清百度| 99视频有精品视频高清| 自拍偷自拍亚洲精品第1页| 久久婷婷人人澡人人爽人人爱| 亚洲ⅴ国产v天堂a无码二区| 久久精品国产男包| 少妇愉情理伦片bd| 久久99精品久久久久久动态图| 国产桃色无码视频在线观看| 人人爽人人添人人超| 国产精品久久久久久av| 日日鲁鲁鲁夜夜爽爽狠狠| 亚洲中文字幕伊人久久无码| 国产亚洲欧美日韩俺去了| 少妇极品熟妇人妻| 国产精品无码av片在线观看播| 麻豆视传媒官网免费观看| 亚洲国产一区二区三区在线观看| 日韩人妻无码一区二区三区久久99 | 国产成人精品一区二区秒播| 国产二级一片内射视频插放| 乱人伦中文视频在线| 久久人人爽人人爽爽久久小说| 久久久精品人妻一区二区三区四| 亚洲妇熟xxxx妇色黄| 国产精品色拉拉|