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  4. Recombinant Mouse POU domain, class 4, transcription factor 1 (Pou4f1)

Recombinant Mouse POU domain, class 4, transcription factor 1 (Pou4f1)

  • 中文名稱：
    小鼠Pou4f1重組蛋白
  • 貨號：
    CSB-YP018400MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Pou4f1重組蛋白
  • 貨號：
    CSB-EP018400MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Pou4f1重組蛋白
  • 貨號：
    CSB-EP018400MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Pou4f1重組蛋白
  • 貨號：
    CSB-BP018400MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Pou4f1重組蛋白
  • 貨號：
    CSB-MP018400MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Pou4f1
  • Uniprot No.：
  • 別名：
    Pou4f1; Brn-3; Brn3; Brn3a; POU domain; class 4; transcription factor 1; Brain-specific homeobox/POU domain protein 3A; Brain-3A; Brn-3A; Brn-3.0
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-421
  • 氨基酸序列
    MMSMNSKQPH FAMHPTLPEH KYPSLHSSSE AIRRACLPTP PLQSNLFASL DETLLARAEA LAAVDIAVSQ GKSHPFKPDA TYHTMNSVPC TSTSTVPLAH HHHHHHHHQA LEPGDLLDHI SSPSLALMAG AGGAGAAGGG GGAHDGPGGG GGPGGGGGPG GGGPGGGGGG GGPGGGGGGP GGGLLGGSAH PHPHMHGLGH LSHPAAAAAM NMPSGLPHPG LVAAAAHHGA AAAAAAAAAG QVAAASAAAA VVGAAGLASI CDSDTDPREL EAFAERFKQR RIKLGVTQAD VGSALANLKI PGVGSLSQST ICRFESLTLS HNNMIALKPI LQAWLEEAEG AQREKMNKPE LFNGGEKKRK RTSIAAPEKR SLEAYFAVQP RPSSEKIAAI AEKLDLKKNV VRVWFCNQRQ KQKRMKFSAT Y
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor. Ativates BCL2 expression and protects neuronal cells from apoptosis (via the N-terminal domain). Induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins. Exerts its major developmental effects in somatosensory neurons and in brainstem nuclei involved in motor control. Stimulates the binding affinity of the nuclear estrogene receptor ESR1 to DNA estrogen response element (ERE), and hence modulates ESR1-induced transcriptional activity. May positively regulate POU4F2 and POU4F3. Regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord. Plays a role in TNFSF11-mediated terminal osteoclast differentiation. Negatively regulates its own expression interacting directly with a highly conserved autoregulatory domain surrounding the transcription initiation site.; Able to act as transcription factor, cannot regulate the expression of the same subset of genes than isoform 1. Does not have antiapoptotic effect on neuronal cells.
  • 基因功能參考文獻：
    1. This study showed that three genes were found to be consistently regulated by Brn3a throughout postnatal retina development - Mapk10, Tusc5 and Cdh4. PMID: 29958540
    2. Double morphant embryos targeted with morpholino oligonucleotides to both TFs develop significant cardiac defects (looping abnormalities and valve defects) suggesting essential roles for Brn-3a and Brn-3b in developing hearts. PMID: 28594399
    3. Pou4f1 and pou4f2 are dispensable for the long-term survival of adult retinal ganglion cells in mice. PMID: 24736625
    4. The deficiency of Pou4f1 who perform poorly in motivation-based locomotor behaviors, such as voluntary wheel running and the accelerating rotarod, but show only minor abnormalities in gait and balance and exhibit normal levels of basal locomotion. PMID: 25143617
    5. Data indicate that Brn3 transcription factors Brn3b affects Brn3a and Brn3c positive Retinal Ganglion Cells (RGCs) in cell autonomous and non-cell autonomous fashion. PMID: 24116103
    6. The results demonstrated a critical role for Brn3a in generating dorsal root ganglia sensory neuron diversity and regulating sensory afferent projections to the central targets. PMID: 22326227
    7. neither Brn3a nor Brn3c are expressed in intrinsically photosensitive retinal ganglion cells PMID: 21935940
    8. Brn3 gene expression patterns in the retina and inner ear, these experiments suggest a deep functional similarity among primary somatosensory neurons, spiral and vestibular ganglion neurons, and retinal ganglion cells PMID: 22262898
    9. Progressive increase in IOP and loss of Brn3a signals in D2 animals were consistent with glaucoma progression starting after 6 months of age. PMID: 21757588
    10. data define AR as a direct Brn-3a interactor and verify a simple interacting protein prediction methodology that is likely to be useful for many other proteins PMID: 20228055
    11. Data show that Brn3a acts upstream of the Runx factors, which then repress TrkB expression to allow establishment of the non-overlapping Trk receptor profiles and correct terminally differentiated phenotypes. PMID: 20096094
    12. Brn3a regulates the transition from neurogenesis to terminal differentiation and represses non-neural gene expression in the trigeminal ganglion. PMID: 19877281
    13. Deficiency of Brn-3a may cause the increase and decrease of Cgrp-immunoreactive expression in small dorsal root ganglion (DRG) neurons projecting to the dorsal column and large DRG neurons projecting to the deep dorsal horn, respectively. PMID: 11930150
    14. Nociceptors and low-threshold mechanoreceptors with medium-sized to large cell bodies in the trigeminal ganglion may be sensitive to the loss of Brn-3a. PMID: 12225879
    15. Brn3a locus functions as a self-regulating unit to maintain a constant expression level of this key regulator of neural development.Sensory expression of Brn3a is regulated by a specific enhancer, Brn3a binds to conserved sites within this enhancer PMID: 12441296
    16. Axon growth is markedly disturbed in Brn3a knockout mice; it is unlikely that Brn3a targets Bcl-2 or mediates the defects in axon guidance and neuronal survival observed in the sensory ganglia of Brn3a knockout mice. PMID: 12598723
    17. in Brn-3a gene two functions are separately controlled with an N-terminal domain being essential for neuronal survival, whereas the POU domain is essential for neurite outgrowth. PMID: 15194866
    18. Regulatory role in trigeminal ganglion growth conserved in more posterior sensory ganglia but not in CNS neurons. PMID: 15253936
    19. Hsp27 expression and cell survival are regulated by the POU transcription factor Brn3a PMID: 15272315
    20. HIPK2, through regulation of Brn3a-dependent gene expression, is a critical component in the transcriptional machinery that controls sensory neuron survival PMID: 15492043
    21. Interaction with Brn-3a in sensory neurons may be critical for modulating p53-mediated gene expression and hence cell fate. PMID: 15532030
    22. a crucial role for Brn-3a in determining the pathway taken by p53 when co-expressed during development and thus in controlling the fate of these cells. PMID: 15598651
    23. The present study suggests that Brn-3a may normally suppress TH expression in many small DRG neurons but activate TH expression in large DRG neurons. PMID: 15725417
    24. Brn-3a is required for the generation of proprioceptors in the mesencephalic trigeminal tract nucleus. PMID: 16040009
    25. Brn3a is expressed in retinal ganglion cells innervating the principal retinothalamic/retinocollicular pathway mediating cortical vision. PMID: 16354917
    26. expression of the developmental regulator FGF10 is approximately 35-fold increased in the developing trigeminal ganglia of Brn3a-null mice PMID: 16838370
    27. Site occupancy by Brn3a can be correlated with evolutionary conservation of the genomic regions containing the recognition sites and also with histone modifications. PMID: 17196582
    28. Brn3a represses differences in gene expression between sensory neurons generated at different axial levels, and regulates developmental gene expression; functionally similar populations of neurons are generated from different embryological substrates. PMID: 17239249
    29. Data suggest that Brn-3a and b POU factors may play an important role in the development and maintenance of critical cell types and structures within the heart, in part via developmental regulation of myocardial Hsp27 expression. PMID: 18368538
    30. results suggest that co-factors binding to p73 C terminus facilitate activation on Bax but not p21 CIP1/Waf1 promoter and that Brn-3a modulates this interaction PMID: 18421303
    31. Data show that Pou4f1 is regionally enriched in the Brainstem (Pons and Medulla) of mouse brain. PMID: 18625066
    32. Brn-3a deficiency affects the number and cell size of CGRP- and calcium-binding protein-containing neurons. PMID: 19288186
    33. Loss of Brn3a leads to an increase in the ratio of bistratified to monostratified RGCs, with only modest RGC loss and little effect on central projections. PMID: 19323995

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  • 亞細胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    POU transcription factor family, Class-4 subfamily
  • 組織特異性：
    Expressed in mature osteoclasts (at protein level). Brain, peripheral sensory nervous system and retina. In the adult nervous system, predominates in the medial habenula, superficial gray of the superior colliculus, red nucleus, mesencephalic nucleus of t
  • 數據庫鏈接：


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