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NLGN4X Antibody

  • 中文名稱:
    NLGN4X兔多克隆抗體
  • 貨號:
    CSB-PA843131LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Immunofluorescence staining of Hela cells with CSB-PA843131LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) NLGN4X Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    NLGN4X
  • 別名:
    ASPGX2 antibody; AUTSX2 antibody; HLNX antibody; HNL4X antibody; HNLX antibody; KIAA1260 antibody; neuroligin 4, X-linked antibody; Neuroligin X antibody; Neuroligin-4 antibody; NL4 antibody; NLGN antibody; NLGN4 antibody; NLGN4X antibody; NLGNX_HUMAN antibody; OTTHUMP00000022863 antibody; OTTHUMP00000022864 antibody; OTTHUMP00000022865 antibody; X-linked antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Neuroligin-4, X-linked protein (383-494AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,NLGN4X Antibody (CSB-PA843131LA01HU),的標記方式是Non-conjugated。對于NLGN4X Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA843131LB01HU NLGN4X Antibody, HRP conjugated ELISA
    FITC CSB-PA843131LC01HU NLGN4X Antibody, FITC conjugated
    Biotin CSB-PA843131LD01HU NLGN4X Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IF 1:200-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Putative neuronal cell surface protein involved in cell-cell-interactions.
  • 基因功能參考文獻:
    1. NLGN4X might represent novel biomarkers and therapeutic targets for breast cancer. Inhibition of NLGN4X may be a new target for the prevention and treatment of breast cancer PMID: 29244827
    2. Noncoding polymorphisms on NLGN4X may be associated to autism suggesting the key role of NLGN4X in autism pathophysiology and in its male prevalence. PMID: 27782075
    3. Endogenous NLGN4X is intensely phosphorylated on T707 upon PKC stimulation in human neurons. PMID: 25675530
    4. In vitro models show NLGN4X knockdown directly impacts neurodevelopmental process during the formation of neurons and their connections. PMID: 23710042
    5. Five genes have been directly disrupted in Tourette Syndrome by independent genomic rearrangements and copy number variations with unique breakpoints. PMID: 22948383
    6. The autism-associated DeltaE4 mutation in NLGN4 compromises the ability of NLGN4 to localize correctly to the cell surface when overexpressed and to induce synaptic differentiation. PMID: 21278334
    7. results indicate that the genetic variants located in NLGN4 can affect the cognitive abilities of boys. PMID: 20714171
    8. Results suggest that unique conformational reshaping of the neuroligin 4 surface is required to permit neurexin 1beta association. PMID: 20543817
    9. finding further contributes to consideration of neuroligins as probable candidate genes for future molecular genetic studies, suggesting that a defect of synaptogenesis may predispose to autism PMID: 19645625
    10. Scanning and sequencing of 2.5Mb of the NLGN4 genes reveals an association of NLGN4 structural variants at highly conserved amino acids with an estimated attributable risk for autism of about 3% in the cohorts studies. PMID: 15622415
    11. Data indicate that coding mutations in neuroligin 4 are very rarely associated to autism spectrum disorders. PMID: 16508939
    12. Splice variants of the NLGN4 gene are associated with autism. PMID: 16648374
    13. Syntrophin-gamma2 (SNTG2) is a de novo binding partner of X-linked neuroligin 4, which correlates with autism-related mutations. PMID: 17292328
    14. NLGN4 mutations can be associated with a wide spectrum of neuropsychiatric conditions and that carriers may be affected with milder symptoms PMID: 18231125
    15. The results suggest a positive association between the genetic variants of the NLGN4 and NSMR in the Chinese children from Qinba Mountains Region. PMID: 19125102
    16. This study indicated that the phenotypic spectrum of NLGN4X mutations and overexpressed NLGN4X transcript is associated with autism and nonsyndromic mental profound mental retardation. PMID: 19545860
    17. NLGN4X gene is associated with autistic traits, empathy, and Asperger syndrome. PMID: 19598235
    18. Two brothers with classical autism spectrum disorder carry a single amino-acid substitution in neuroligin 4 (Arg87Trp). The substitution is absent from the brothers' asymptomatic parents, suggesting that it arose in the maternal germ line. PMID: 19726642

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  • 相關疾?。?/div>
    Autism, X-linked 2 (AUTSX2); Asperger syndrome, X-linked, 2 (ASPGX2)
  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic density membrane.
  • 蛋白家族:
    Type-B carboxylesterase/lipase family
  • 組織特異性:
    Expressed at highest levels in heart. Expressed at lower levels in liver, skeletal muscle and pancreas and at very low levels in brain.
  • 數據庫鏈接:

    HGNC: 14287

    OMIM: 300427

    KEGG: hsa:57502

    STRING: 9606.ENSP00000275857

    UniGene: Hs.21107



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