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  4. Recombinant Human Neuroligin-4, X-linked (NLGN4X), partial

Recombinant Human Neuroligin-4, X-linked (NLGN4X), partial

  • 中文名稱：
    人NLGN4X重組蛋白
  • 貨號：
    CSB-YP843131HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人NLGN4X重組蛋白
  • 貨號：
    CSB-EP843131HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人NLGN4X重組蛋白
  • 貨號：
    CSB-EP843131HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人NLGN4X重組蛋白
  • 貨號：
    CSB-BP843131HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人NLGN4X重組蛋白
  • 貨號：
    CSB-MP843131HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    NLGN4X
  • Uniprot No.：
  • 別名：
    ASPGX2; AUTSX2; HLNX; HNL4X; HNLX; KIAA1260; neuroligin 4, X-linked; Neuroligin X; Neuroligin-4; NL4; NLGN; NLGN4; NLGN4X; NLGNX_HUMAN; OTTHUMP00000022863; OTTHUMP00000022864; OTTHUMP00000022865; X-linked
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Putative neuronal cell surface protein involved in cell-cell-interactions.
  • 基因功能參考文獻(xiàn)：
    1. NLGN4X might represent novel biomarkers and therapeutic targets for breast cancer. Inhibition of NLGN4X may be a new target for the prevention and treatment of breast cancer PMID: 29244827
    2. Noncoding polymorphisms on NLGN4X may be associated to autism suggesting the key role of NLGN4X in autism pathophysiology and in its male prevalence. PMID: 27782075
    3. Endogenous NLGN4X is intensely phosphorylated on T707 upon PKC stimulation in human neurons. PMID: 25675530
    4. In vitro models show NLGN4X knockdown directly impacts neurodevelopmental process during the formation of neurons and their connections. PMID: 23710042
    5. Five genes have been directly disrupted in Tourette Syndrome by independent genomic rearrangements and copy number variations with unique breakpoints. PMID: 22948383
    6. The autism-associated DeltaE4 mutation in NLGN4 compromises the ability of NLGN4 to localize correctly to the cell surface when overexpressed and to induce synaptic differentiation. PMID: 21278334
    7. results indicate that the genetic variants located in NLGN4 can affect the cognitive abilities of boys. PMID: 20714171
    8. Results suggest that unique conformational reshaping of the neuroligin 4 surface is required to permit neurexin 1beta association. PMID: 20543817
    9. finding further contributes to consideration of neuroligins as probable candidate genes for future molecular genetic studies, suggesting that a defect of synaptogenesis may predispose to autism PMID: 19645625
    10. Scanning and sequencing of 2.5Mb of the NLGN4 genes reveals an association of NLGN4 structural variants at highly conserved amino acids with an estimated attributable risk for autism of about 3% in the cohorts studies. PMID: 15622415
    11. Data indicate that coding mutations in neuroligin 4 are very rarely associated to autism spectrum disorders. PMID: 16508939
    12. Splice variants of the NLGN4 gene are associated with autism. PMID: 16648374
    13. Syntrophin-gamma2 (SNTG2) is a de novo binding partner of X-linked neuroligin 4, which correlates with autism-related mutations. PMID: 17292328
    14. NLGN4 mutations can be associated with a wide spectrum of neuropsychiatric conditions and that carriers may be affected with milder symptoms PMID: 18231125
    15. The results suggest a positive association between the genetic variants of the NLGN4 and NSMR in the Chinese children from Qinba Mountains Region. PMID: 19125102
    16. This study indicated that the phenotypic spectrum of NLGN4X mutations and overexpressed NLGN4X transcript is associated with autism and nonsyndromic mental profound mental retardation. PMID: 19545860
    17. NLGN4X gene is associated with autistic traits, empathy, and Asperger syndrome. PMID: 19598235
    18. Two brothers with classical autism spectrum disorder carry a single amino-acid substitution in neuroligin 4 (Arg87Trp). The substitution is absent from the brothers' asymptomatic parents, suggesting that it arose in the maternal germ line. PMID: 19726642

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  • 相關(guān)疾病：
    Autism, X-linked 2 (AUTSX2); Asperger syndrome, X-linked, 2 (ASPGX2)
  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic density membrane.
  • 蛋白家族：
    Type-B carboxylesterase/lipase family
  • 組織特異性：
    Expressed at highest levels in heart. Expressed at lower levels in liver, skeletal muscle and pancreas and at very low levels in brain.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 14287

    OMIM: 300427

    KEGG: hsa:57502

    STRING: 9606.ENSP00000275857

    UniGene: Hs.21107



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