Recombinant Saccharomyces cerevisiae Mitochondrial import inner membrane translocase subunit TIM17 (TIM17)

in vitro E.coli expression system

中文名稱：

釀酒酵母TIM17重組蛋白
貨號：

CSB-CF331035SVG
規(guī)格：
來源：

in vitro E.coli expression system
其他：

產(chǎn)品詳情
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

基因名：

TIM17
Uniprot No.：

P39515
別名：

TIM17; MIM17; MPI2; SMS1; YJL143W; J0648; Mitochondrial import inner membrane translocase subunit TIM17; Mitochondrial inner membrane protein MIM17; Mitochondrial protein import protein 2
種屬：

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
蛋白長度：

full length protein
表達(dá)區(qū)域：

1-158
氨基酸序列

MSADHSRDPCPIVILNDFGGAFAMGAIGGVVWHGIKGFRNSPLGERGSGAMSAIKARAPV LGGNFGVWGGLFSTFDCAVKAVRKREDPWNAIIAGFFTGGALAVRGGWRHTRNSSITCAC LLGVIEGVGLMFQRYAAWQAKPMAPPLPEAPSSQPLQA
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標(biāo)簽：

N-terminal 10xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

功能：

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
基因功能參考文獻(xiàn)：
1. Mutations in TM1 and TM2 impaired the interaction of Tim17 with Tim23, component of the translocation channel, whereas mutations in TM3 compromised binding of the import motor. The authors identified residues in the matrix-facing region of Tim17 involved in binding of the import motor. PMID: 28165323
2. charged residues in Tim17 are critical for the preprotein-induced gating of the TIM23 translocase PMID: 15618217
3. Tim17p is required for twin pore structure and provides the voltage gate for the TIM23 channel complex. PMID: 17148445
4. Overexpression of TIM17 prevents the complete loss of mtDNA in cells lacking Abf2. PMID: 18826960
亞細(xì)胞定位：

Mitochondrion inner membrane; Multi-pass membrane protein.
蛋白家族：

Tim17/Tim22/Tim23 family
數(shù)據(jù)庫鏈接：

KEGG: sce:YJL143W

STRING: 4932.YJL143W