在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Rat cGMP-gated cation channel alpha-1 (Cnga1)

  • 中文名稱:
    Recombinant Rat cGMP-gated cation channel alpha-1(Cnga1)
  • 貨號:
    CSB-CF720326RA
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    Cnga1; Cncg; Cncg1; cGMP-gated cation channel alpha-1; Cyclic nucleotide-gated cation channel 1; Cyclic nucleotide-gated channel alpha-1; CNG channel alpha-1; CNG-1; CNG1; Cyclic nucleotide-gated channel, photoreceptor; Rod photoreceptor cGMP-gated channel subunit alpha
  • 種屬:
    Rattus norvegicus (Rat)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-683
  • 氨基酸序列
    MKTNIINTWHSFVNIPNVVVPAIEKEIRRMENGACSSFSDNDNGSLSEESENEDSLFRSN SYRRRGPSQREHYLPGTMALFNVNNSSNKDQDPKEKKKKKKEKKSKADDKKESKKDPEKK KKKEKEKEKKKEEKPKEKKEEEKKEVVVIDPSGNMYYNWLFCITLPVMYNWTMIIARACF DELQSDYLEYWLIFDYVSDVVYLADMFVRTRTGYLEQGLLVKDELKLIEKYKANLQFKLD VLSVIPTDLLYFKFGWNYPEIRLNRLLRISRMFEFFQRTETRTNYPNIFRISNLVMYIVI IIHWNACVYYSISKAIGFGNDTWVYPDVNDPEFGRLARKYVYSLYWSTLTLTTIGETPPP VLDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQSRVDAIKQYMNFRNVSKD MEKRVIKWFDYLWTNKKTVDEREVLRYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLV ELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGITQFVVLSDGSYFGEISI LNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGRQILMKDGLL DINIANLGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESMQQKLKQRLTKVEKFLKPL IETEFSALEEPGGESEPTESLQG
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential.
  • 基因功能參考文獻:
    1. Histamine depolarizes projection neurons but not interneurons in the cerebellar nuclei via the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels coupled to histamine H2 receptors. PMID: 25633097
    2. Insulin receptor (IR), an integral membrane protein, directly phosphorylates the CNGA1 subunit of CNG channels that in turn affects the function of these channels negatively. CNGA1 is a direct substrate of IR. PMID: 23032687
    3. estrogen and progesterone act in renal tissues modulating CNG-A1 and Na/K ATPase gene expression PMID: 22759964
    4. Data demonstrate that CNGA1 is expressed in rat cerebellar granule cells and forms functional channels. PMID: 21809342
    5. Data show robust CNGA1 (but not CNGA2 or CNGA3) channel expression principally in rat alveolar type I cells and suggest that CNGA1 channels mediate cGMP-stimulated, amiloride-insensitive, lung liquid absorption. PMID: 21559843
    6. Transcripts for a functional CNG ion channel exist in the cochlea resulting from combinations of CNG2 with CNG5 and CNG4.3. CNG2 and CNG5 immunoreactivity in hair cell stereocilia suggests a role for cAMP-sensitive CNG channels in signal transduction. PMID: 11834291
    7. NO activates the olfactory cyclic nucleotide-gated conductance independent from cGMP in isolated rat olfactory receptor neurons. PMID: 12865170
    8. CNG channels switch on and off the olfactory signaling pathway, and that the on and off signals may both be amplified by the subsequent olfactory signaling steps. PMID: 16940558
    9. Our data imply that HCN-expressing GABAergic neurons provide rhythmic drive in all phases of the hippocampal theta activity. PMID: 18565991
    10. suggest a potential role for HCN channels in regulation of glucagon secretion via modulating Ca(2+) and Na(+) channel activities PMID: 18850083

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Cyclic nucleotide-gated cation channel (TC 1.A.1.5) family, CNGA1 subfamily
  • 組織特異性:
    Rod cells in the retina.
  • 數據庫鏈接:


主站蜘蛛池模板: 日本肥老妇色xxxxx日本老妇| 18禁超污无遮挡无码免费动态图| 制服丝袜中文字幕在线| 午夜欧美精品久久久久久久| 国产免费mv大全视频网站| 国产精品自在线一区| 亚洲国产欧美在线人成| 亚洲日韩中文字幕一区| 69天堂人成无码免费视频| 国产+成+人+亚洲欧洲自线| 中字乱码视频| 暖暖 在线 日本 免费 中文| 欧洲av成本人在线观看免费| 亚洲伦无码中文字幕另类| 中国美女牲交视频| 国产午夜福利在线观看视频| 青草内射中出高潮| 亚洲乱码在线卡一卡二卡新区豆瓣 | 精品无码国产自产拍在线观看| 少妇av一区二区三区无码| 最新国产精品拍自在线观看| 久久综合国产乱子伦精品免费| 日本爽爽爽爽爽爽在线观看免| 国产男女无遮挡猛进猛出| 久久久www成人免费看片| 超清无码波多野吉衣中文| 九九九免费观看视频| 亚洲ⅴ国产v天堂a无码二区| 亚洲孰妇无码av在线播放| 妺妺窝人体色www在线观看| 无套内射在线无码播放| 中文字幕三级人妻无码视频| 欧美人与动性xxxxbbbb| 又粗又黑又大的吊av| 国产亚洲情侣一区二区无| 中文字幕av伊人av无码av狼人| 少妇人妻无码专区视频| 午夜裸体性播放| 中文字幕精品视频在线看免费 | 亚洲精品熟女国产| 欧美熟妇性xxxx交潮喷|