在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Rat Sterol regulatory element-binding protein 2 (Srebf2)

  • 中文名稱:
    大鼠Srebf2重組蛋白
  • 貨號:
    CSB-CF660998RA
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    Srebf2; Sterol regulatory element-binding protein 2; SREBP-2; Sterol regulatory element-binding transcription factor 2
  • 種屬:
    Rattus norvegicus (Rat)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-476
  • 氨基酸序列
    MDENSELGGLETMETLTELGDELTLGDIDEMLQFVSNQVGEFSDLFSEQLCSSFPGGGGG SGSGGTSNNSSGRGTSGGAADPAVQRSFSQVPLSTFSPSSTSPQAPALQVKVSPTPPRAT PVLQPRPQPQPQPPAQLQQQTVMITPTFSTAPQTRIIQQPLIYQNAATSFQVLQPQVQSL VTSSQVQPVTIQQQVQTVQAQRVLTQTANGTLQTLAPATVQTVATPQVQQVPVLVQPQII KTDSLVLTTLKTDGSPVMAAVQNPALTALTAPIQTAALQVPTLVGSNGAILTTMPVMMGQ EKVPIKQVPGGVKQLEPPKEGERRTTHNIIEKRYRSSINDKIIELKDLVMGTDAKMHKSG VLRKAIDYIKYLQQVNHKLRQENMVLKLANQKNKLLKGIDLGSLVDSDVDLKIDDFNQNV LLMSPPASDSGSQAGFSPYSIDSEPGSPLLDDAKVKDEPDSPPVALGMVDRSRILL
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 2), which is embedded in the endoplasmic reticulum membrane. Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis.; Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Regulates transcription of genes related to cholesterol synthesis pathway.
  • 基因功能參考文獻:
    1. SREBP2, which can be modulated by the impairment of cerebral cholesterol homeostasis, has a direct role on BACE1 expression PMID: 21726644
    2. prior to weaning, SREBP-2 is proteolytically processed to the mature form PMID: 12488438
    3. Overexpression of the SREBP processing system contributed to the activation of LXRalpha by maintaining high oxysterol levels in tissue. PMID: 16941710
    4. Results indicate that the rapid induction of the hepatic LDL receptor by thyroid hormone is likely due to direct interaction with thyroid response elements rather than indirectly by a mechanism involving SREBP-2. PMID: 17572141
    5. reduced cholesterol concentrations in liver and plasma of rats administered an oxidized oil were due to an inhibition of the activation of SREBP-2 PMID: 17709436
    6. nephrotic hypercholesterolemia may be associated with dysregulation of hepatic tissue SREBP-2 PMID: 17884448
    7. Taken together, the above results show that there is high level of SREBP-2 expression in the normal hippocampus, and that neuronal injury results in a significant reduction of SREBP-2 expression in the damaged areas. PMID: 19124072
    8. Results describe the characterization of a novel isoform of the transcription factor SREBP2, which is highly enriched in spermatogenic cells, is expressed in a stage-dependent fashion, and is not subject to feedback control by sterols. PMID: 12446768
    9. data indicate that polyunsaturated fatty acids (PUFA) suppress the in vivo proteolytic release of sterol regulatory element binding proteins-1 and -2, but the effect on SREBP-2 is transitory. PMID: 12421847
    10. Studies indicate that, prior to weaning, SREBP-2 but not SREBP-1 is proteolytically processed to the mature form. PMID: 12488438

    顯示更多

    收起更多

  • 亞細胞定位:
    [Sterol regulatory element-binding protein 2]: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein.; [Processed sterol regulatory element-binding protein 2]: Nucleus.
  • 蛋白家族:
    SREBP family
  • 數據庫鏈接:


主站蜘蛛池模板: 免费无码毛片一区二区app| 久久精品无码一区二区www| 国产精品美女久久久久av爽李琼 | 国产成人精品一区二区秒拍| 成人免费视频一区二区| 色噜噜亚洲男人的天堂| 最新亚洲中文字幕在线观看| 亚洲熟妇丰满多毛xxxx| 人妻人人做人做人人爱| 亚洲精品无码av中文字幕电影网站| 人妻换着玩又刺激又爽| 99无码熟妇丰满人妻啪啪| 亚洲男同志网站| 亚洲最新版av无码中文字幕| 国产精品亚洲二区在线看 | 秋霞午夜成人久久电影网| 国产日产欧产精品精品蜜芽| 超清制服丝袜无码av福利网| 久久久久久国产精品免费免费| 国产精品喷浆| 成人午夜视频精品一区| 亚洲国内精品自在线影院| 精品一区二区成人精品| 欧美中日韩免费观看网站| xx性欧美肥妇精品久久久久久 | 国产精品∧v在线观看| 色135综合网| 囯产精品一品二区三区| 亚洲中文有码字幕日本第一页| 亚洲另类激情专区小说| 国产亚洲精品久久久久久青梅| 国产96在线 | 韩国| 丰满少妇人妻hd高清大乳在线| 亚洲色成人www永久在线观看| 少妇久久久久久久久久| 亚洲精品国产综合久久一线| 日本 精品 高清不卡| 在线视频网站www色| 国产精品原创巨作av女教师| 欧美大香线蕉线伊人久久| 轻点好疼好大好爽视频|