在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Rat Sphingomyelin phosphodiesterase 2 (Smpd2)

  • 中文名稱:
    大鼠Smpd2重組蛋白
  • 貨號:
    CSB-CF866853RA
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
    Smpd2
  • Uniprot No.:
  • 別名:
    Smpd2; Sphingomyelin phosphodiesterase 2; Lyso-platelet-activating factor-phospholipase C; Lyso-PAF-PLC; Neutral sphingomyelinase; N-SMase; nSMase
  • 種屬:
    Rattus norvegicus (Rat)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-422
  • 氨基酸序列
    MKHNFSLRLRVFNLNCWDIPYLSKHRADRMKRLGDFLNLESFDLALLEEVWSEQDFQYLK QKLSLTYPDAHYFRSGIIGSGLCVFSRHPIQEIVQHVYTLNGYPYKFYHGDWFCGKAVGL LVLHLSGLVLNAYVTHLHAEYSRQKDIYFAHRVAQAWELAQFIHHTSKKANVVLLCGDLN MHPKDLGCCLLKEWTGLRDAFVETEDFKGSEDGCTMVPKNCYVSQQDLGPFPFGVRIDYV LYKAVSGFHICCKTLKTTTGCDPHNGTPFSDHEALMATLCVKHSPPQEDPCSAHGSAERS ALISALREARTELGRGIAQARWWAALFGYVMILGLSLLVLLCVLAAGEEAREVAIMLWTP SVGLVLGAGAVYLFHKQEAKSLCRAQAEIQHVLTRTTETQDLGSEPHPTHCRQQEADRAE EK
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Hydrolyze 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor).
  • 基因功能參考文獻:
    1. Data herein confirm the role of ceramide in increased apoptotic cell death and highlight the protective effect of N-SMase inhibition in down-regulation of apoptotic stimuli responses occurring in hepatic ischemia reperfusion injury. PMID: 28277984
    2. ANG II stimulates ceramide formation via the activation of nSMase in the kidney. PMID: 25354938
    3. sphingomyelinase causes an increase in intracellular chloride, which is known to inhibit glycogen synthase phosphatase PMID: 10561609
    4. a novel physiological function as a new mechanosensor initiating the ERK cascade PMID: 12473648
    5. These results show that the process of aging causes increased basal NSMase-2 activity in hepatocytes, which in turn leads to IRAK-1 stabilization, JNK potentiation, and ultimately IL-1beta hyperresponsiveness. PMID: 17668873
    6. this report demonstrates that depletion of cellular GSH during aging plays an important role in regulating the hepatic response to IL-1beta by inducing NSMase-2 activity. PMID: 17693623
    7. Smpd2 inhibition participates in the benefits of acetylcysteine treatment in post-myocardial infarction in failing heart rats. PMID: 17707397

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Neutral sphingomyelinase family
  • 數據庫鏈接:


主站蜘蛛池模板: 欧美变态暴力牲交videos| 亚洲精品成人福利网站app| 亚洲热妇无码av在线播放| 久久国产精品久久久久久| 欧美黑人巨大xxxxx| 国产精品一卡二卡三卡| 天天摸日日摸爽爽狠狠| 另类国产精品一区二区| 国产1卡二卡3卡四卡乱码视频| 三级网站视频在在线播放| 粉色午夜视频| 国产品无码一区二区三区在线| 亚洲欧美日本久久综合网站点击| 成人做爰高潮片免费视频| 99久久国产综合精品五月天| 在线成人www免费观看视频| 午夜福利国产成人无码gif动图| 日日拍夜夜嗷嗷叫|日日摸| 99这里有精品视频视频| 精品无码国产污污污免费| 中文字幕日产无码| 女人色极品影院| 亚洲精品一区二区不卡| 国产成年无码久久久免费| 亚洲精品一线二线三线无人区| 中文在线最新版天堂| 97人洗澡人人澡人人爽人人模| 亚洲综合欧美制服丝袜| 国产香蕉尹人在线观看视频| 熟妇与小伙子matur老熟妇e| 日韩免费无码一区二区视频| 国产精品嫩草影院久久| 九九99无码精品视频在线观看| 国产精品人人做人人爽人人添| 成熟丰满熟妇高潮xxxxx视频 | 成 人 综合 亚洲另类| 亚洲一区二区三区无码av| 亚洲精品乱码久久久久久自慰 | 黄网站成人片免费视频| 99久久国产综合精品五月天| 天天摸日日摸狠狠添|