在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Rat NKG2-D type II integral membrane protein (Klrk1)

  • 中文名稱:
    大鼠Klrk1重組蛋白
  • 貨號(hào):
    CSB-CF012474RA
  • 規(guī)格:
  • 來(lái)源:
    in vitro E.coli expression system
  • 其他:

產(chǎn)品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    Klrk1; Nkg2d; Nkrp2; NKG2-D type II integral membrane protein; Killer cell lectin-like receptor subfamily K member 1; NK cell receptor D; NK lectin-like receptor; NKLLR; NKG2-D-activating NK receptor; NKR-P2; CD antigen CD314
  • 種屬:
    Rattus norvegicus (Rat)
  • 蛋白長(zhǎng)度:
    full length protein
  • 表達(dá)區(qū)域:
    1-215
  • 氨基酸序列
    MSKCHNYDLKPAKWDTSQEHQKQRSALPTSRPGENGIIRRRSSIEELKISPLFVVRVLVAAMTIRFTVITLTWLAVFITLLCNKEVSVSSREGYCGPCPNDWICHRNNCYQFFNENKAWNQSQASCLSQNSSLLKIYSKEEQDFLKLVKSYHWMGLVQSPANGSWQWEDGSSLSPNELTLVKTPSGTCAVYGSSFKAYTEDCSNPNTYICMKRAV
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins.
  • 基因功能參考文獻(xiàn):
    1. Blockade of NKG2D significantly attenuated ischemia-reperfusion injury in a cardiac transplantation model. PMID: 23953572
    2. Natural killer (NK) cell-activating receptor NKG2D is important for NK-mediated killing of hepatoma McA tumor cells; NK cell cytotoxicity against McA-RH7777 is mediated by both NKp30 and NKG2D. PMID: 21106845
    3. NKG2D acts as a natural cytotoxicity receptor to stimulate perforin-mediated elimination of ligand-expressing tumor cells. PMID: 12421908
    4. NKG2D is required for cytolysis of tumor cells, including autologous tumor cells from patients with ovarian cancer, and in vivo antitumor activity PMID: 16339517
    5. We have reported the involvement of NKR-P2 in rat dendritic cell (DC) activation. We demonstrate the potential of agonistic anti-NKR-P2 mAb (1A6), which mimics the NKR-P2 ligand and induces activation and maturation of DCs. PMID: 17369187
    6. A novel role of Irp94 as a ligand for NKR-P2 on DCs, which in turn executes both innate and adaptive immunity, was demonstrated. PMID: 18178852
    7. In vitro cytotoxic assays reveal that a subset of rat monocytes/macrophages expressing both CD4 and CD8 antigens can kill certain tumor cells in a cell-cell contact-dependent manner through recognition of NKG2D ligands. PMID: 18292522
    8. the splice forms of NKG2D arise from alternative promoters and that the NKG2D-L promoter is derived from a B1 retrotransposon. PMID: 19304755

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cell membrane; Single-pass type II membrane protein.
  • 組織特異性:
    Expressed by natural killer cells and by resting thoracic duct CD4+ and CD8+ T-cells, but not by thymocytes or other hemopoietic cells. Expressed by DC cells.
  • 數(shù)據(jù)庫(kù)鏈接:


主站蜘蛛池模板: 欧美性猛交xxxx免费视频软件 | 国产在线不卡精品网站| 露脸叫床粗话东北少妇| 中文有码亚洲制服av片| 精品乱码一区二区三区四区| 无码人妻久久一区二区三区| 人妻少妇精品专区性色av| 人妻系列无码专区喂奶 | 97久久精品人人槡人妻人| 亚洲国产精华液网站w| 亚洲精品久久久中文字幕痴女| 国产一区二区在线视频| 国产农村乱人伦精品视频| 野花在线无码视频在线播放| av无码国产在线看免费网站| 99精品国产综合久久久久五月天 | 国产高潮抽搐喷水高清| 少妇精品偷拍高潮少妇小说| 亚洲色成人一区二区三区| 特大黑人娇小亚洲女| 午夜男女爽爽影院免费视频下载 | 国产精品免费视频色拍拍| 日韩精品亚洲人成在线观看| 日韩精品久久无码人妻中文字幕| 香港三级日本三级妇三级| 欧洲日韩亚洲无线在码| aaa午夜级特黄日本大片| 国产在线视频主播区| 一本大道熟女人妻中文字幕在线 | 国内精品伊人久久久久av| 国产巨大爆乳在线观看| 丰满少妇夜夜爽爽高潮水| 无尺码精品产品网站| 亚洲成在人线视av| 天干夜啦天干天干国产免费| 欧美亚洲另类 丝袜综合网 | 破了亲妺妺的处免费视频国产| 精品久久人人爽天天玩人人妻| 国产麻豆剧果冻传媒一区| 人妻系列av无码专区| 久艾草在线精品视频在线观看|