在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Rat Gonadotropin-releasing hormone receptor (Gnrhr)

  • 中文名稱:
    大鼠Gnrhr重組蛋白
  • 貨號(hào):
    CSB-CF009637RA
  • 規(guī)格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產(chǎn)品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    Gnrhr; Gonadotropin-releasing hormone receptor; GnRH receptor; GnRH-R
  • 種屬:
    Rattus norvegicus (Rat)
  • 蛋白長度:
    Full length protein
  • 表達(dá)區(qū)域:
    1-327
  • 氨基酸序列
    MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKL QRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYL KLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRM IYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRV LHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVS EPVNHFFFLFAFLNPCFDPLIYGYFSL
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system.
  • 基因功能參考文獻(xiàn):
    1. the age-dependent basal and regulated Gnrhr transcription could account for the initial blockade and subsequent activation of the reproductive system during development. PMID: 27569529
    2. Prevention of estradiol synthesis blocked the ability of peripheral estradiol administration in ovariectomized rats to enhance hippocampus-dependent memory in a radial-maze task. Hippocampal GnRH receptor antagonism blocked the ability of peripheral estradiol administration in ovariectomized rats to enhance hippocampus-dependent memory. PMID: 28032117
    3. GnRH-R is expressed in the mammary tissues after weaning; GnRH is involved in the involution and tissue remodeling of post-lactating rat mammary tissues PMID: 27349532
    4. Gnrhr promoter sequences are mainly responsible for directing transcriptional programmes and play a predominant role over the species-specific cell environment. PMID: 25556311
    5. Data indicate that GnRH-R expression is strongest in the hippocampus of adult female rats. PMID: 23906992
    6. Rather than using alternate promoters, Gnrhr expression is directed to diverse cell lineages through specific associations of transcription factors acting on distinct response elements along the same promoter. PMID: 22414758
    7. SET protein interacts with intracellular domains of the gonadotropin-releasing hormone receptor and differentially regulates receptor signaling to cAMP and calcium in gonadotrope cells PMID: 23233674
    8. Data demonstrate herein that the onset of GnRHR gene (Gnrhr) expression in the rat hippocampus was unexpectedly delayed as compared to the pituitary and only occurred after birth. PMID: 21123436
    9. Low-level GnRHR expression in the ovaries of rats with cyclophosphamide exposure suggest microenvironment disturbances in the damaged rat ovaries in advanced stage of chemotherapy. PMID: 18024297
    10. Localization of a functional GHRH-R in Henle's loop and its regulation during development and aging suggest roles associated with cellular proliferation, differentiation, and/or water/electrolyte transport PMID: 11897706
    11. Data show that removal of all three carboxyl terminal residues or mutation of the gonadotropin-releasing hormone receptor at Phe(325) caused a complete loss of measurable ligand binding and effector coupling, clearly suggesting a role for Phe(325). PMID: 11997175
    12. results indicate that the GnRH receptor activates both G(q) and G(s) signaling to regulate gene expression in L beta T2 cells PMID: 12050161
    13. role of the GnRHR carboxyl-terminus in the regulation of the GnRHR by RGS (regulators of G protein signaling) proteins PMID: 12062898
    14. The distribution of androgen receptor and its coexistence with gonadotropin releasing hormone receptor in rat submaxillary glands PMID: 12479044
    15. GnRH receptor immunoreactive materials were colocalized in the epithelial cells of the serous acinus and glandular duct of the submaxillary gland PMID: 12697272
    16. Position of Pro and Ser near Glu7.32 in the extracellular loop 3 is critical for the differential ligand selectivity between mammalian and nonmammalian GnRHRs. PMID: 14525953
    17. direct role for the GnRHR in mediating antiproliferative events in two cell systems, neither of which was derived from extrapituitary reproductive tumors. PMID: 14551223
    18. Developmental GnRH-R and gonadotropin beta subunit gene expression is almost entirely GnRH dependent, not only in the juvenile prepubertal stage but also during the infantile period. PMID: 14561652
    19. GnRH receptor can be expressed by gastric smooth muscle cells of rats. PMID: 15188505
    20. the HFRK motif in the membrane-proximal region confers the differential signal transduction pathways between mammalian and nonmammalian GnRHRs PMID: 15563546
    21. there are species-specific dominant negative receptor trafficking effects of the GnRHR between human, rat and mouse PMID: 15886197
    22. GnRH-R mRNA in the pituitary and hypothalamus of long-term ovariectomized (OVX) rats, at different times of day. PMID: 16672174
    23. proportion of the human and the rat WT GnRHR appears to be retained in the endoplasmic reticulum by calnexin, an effect that decreases GnRHR signaling capacity PMID: 17170088
    24. These results, for the first time, support the transcription of GnRHR mRNA and its translation to protein in the rat oviduct throughout the postimplantation period of pregnancy. PMID: 17875654
    25. Results indicate that the residues flanking Glu(7.32) of the mammalian type-I gonadotropin-releasing hormone receptor are important for antagonist as well as agonist selectivity. PMID: 18319619
    26. Both cultured spinal cord neurons of rat embryos and adult rats expressed the GnRH receptor mRNA. GnRH may play other roles independently from its participation in reproductive function. PMID: 19539704

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 數(shù)據(jù)庫鏈接:


主站蜘蛛池模板: 裸身美女无遮挡永久免费视频| 无码人妻丝袜视频在线播免费| av一区二区国产在线视频| av午夜福利一片免费看久久| 熟女人妻在线视频| 色综合网天天综合色中文| 男生白内裤自慰gv白袜男同| 国产99在线 | 欧美| 亚洲精品www久久久久久| 国产精品黄页免费高清在线观看| 国产精华av午夜在线观看| 国产精品videossex国产高清| 中文字幕日本人妻久久久免费| 国产色在线 | 国产| 亚洲a∨精品一区二区三区| 激情综合婷婷色五月蜜桃| 麻花豆传媒剧国产免费mv入口| 色天使亚洲综合一区二区| 亚洲欧美另类精品二区| 国产精品网站在线观看免费传媒| 成人麻豆日韩在无码视频| 久久精品国产男包| 精品无码成人片一区二区98| 最新亚洲春色av无码专区| 日本久久综合久久综合| 婷婷成人小说综合专区| 亚洲国产精品嫩草影院| 国内少妇偷人精品免费| 亚洲国产超清无码专区| 国模杨依粉嫩蝴蝶150p| 亚洲精品一区二区三区蜜臀| 少妇做爰又色又紧夜视频| 激情综合婷婷丁香五月蜜桃| 免费99精品国产自在在线| 国内精品久久久久久久影视| 日韩人妻无码精品二专区 | 丰满少妇熟乱xxxxx视频| 美女内射视频www网站午夜| 少妇spa推油被扣高潮| 久久丫精品系列| 国内精品国产三级国产av|