在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 跨膜蛋白
  4. Recombinant Rat Catechol O-methyltransferase (Comt)

Recombinant Rat Catechol O-methyltransferase (Comt)

  • 中文名稱：
    Recombinant Rat Catechol O-methyltransferase(Comt)
  • 貨號：
    CSB-CF005779RA
  • 規格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產品詳情

  • 基因名：
  • Uniprot No.：
  • 別名：
    Comt; Catechol O-methyltransferase
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-264
  • 氨基酸序列
    MPLAAVSLGLLLLALLLLLRHLGWGLVTIFWFEYVLQPVHNLIMGDTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEMNPDYAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEKCGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGPSSPDKS
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    N-terminal 10xHis-tagged
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
  • 基因功能參考文獻：
    1. The discovered changes in the expression level of catechol-o-methyltransferase , mineralocorticoid receptor , and b-subunit of epithelial sodium channel confirm their involvement in increased sympathetic stimulation of the of hypertensive rats PMID: 27215035
    2. A higher hepatic COMT activity was found in the mineral water group compared with the tap water and tap-water-plus-NaCl groups. On the other hand, adrenal gland COMT mRNA expression decreased in the MW group compared to TW group. PMID: 25560240
    3. COMT inhibition results in increased pain sensitivity and production of proinflammatory mediators. PMID: 24727346
    4. Our findings suggest that COMT regulates dorsal hippocampal neurochemistry and modulates hippocampus-dependent behaviours. PMID: 22815336
    5. ZNF804a regulates expression of the schizophrenia-associated genes PRSS16, COMT, PDE4B, and DRD2 PMID: 22384243
    6. decreased COMT activity was associated with some changes in feeding microstructure in rats and mice PMID: 21851556
    7. investigation of substrate specificity and metabolite profiles of COMT from liver cytosol; studies include molecular modeling PMID: 22071171
    8. analysis of orientation and cellular distribution of membrane-bound catechol-O-methyltransferase in cortical neurons PMID: 21846718
    9. In rat subarachnoid hemorrhage model could induce the expression of COMT in the rat striatum in the early stage. PMID: 21116937
    10. Reduction of COMT enzyme activity, and thereby possible accumulation of catecholamines, inhibits spinal nociceptive activity and attenuates the expression of spinal LTP. PMID: 20219633
    11. significant effects of hormone replacement and gonadectomy on catechol-O-methyltransferase and monoamine oxidase isoforms in both striatum and cortex PMID: 19909795
    12. These results suggest that the decreased expression of COMT may be an important factor leading to the development of hypertension. PMID: 19966533
    13. Contrary to expectations that COMT would be expressed predominantly in non-neuronal cells, the present study shows that neurons are the main cell populations expressing COMT mRNA in the rat forebrain. PMID: 12535946
    14. liver membrane-bound-catechol-O-methyltransferase may be a relevant factor in blood pressure regulation in rats PMID: 14714585
    15. Strong COMT mRNA expression was observed in the suprachiasmatic nucleus throughout its rostrocaudal extent at postnatal day 1 (P1) and P2, and the mRNA levels decreased gradually until P16. PMID: 15167541
    16. Crystals diffract to 1.6 A resolution on a synchrotron-radiation source and belong to the monoclinic space group P2(1). PMID: 16508109
    17. These data provide the first direct evidence that low COMT activity leads to increased pain sensitivity via a beta(2/3)-adrenergic mechanism. PMID: 17084978
    18. Suppression of catechol-O-methyltransferase activities, decrease in degradation of norepinephrine (NE), and increase in NE release by blunting of alpha(2)-AR function may be involved in salt-sensitive hypertension in Dahl salt-sensitive rats. PMID: 17510509
    19. Catechol-O-methyltransferase activity and protein expression were increased in the substantia nigra after inflammation induced by lipopolysaccharides. PMID: 17573159
    20. Modulation of COMT activity may play a role in the regulation of myometrial contractility and cervical ripening during pregnancy. PMID: 18042640
    21. pI differences distinguishing between the various COMT forms are due to some as yet unidentified structural modification(s) PMID: 18831714
    22. This work reports the first crystallographic study of Rat COMT complexed with non-nitrocatechol inhibitor. PMID: 19056347
    23. The crystal structures of the Apo and Holo form of rat catechol-O-methyltransferase were determined and compared. PMID: 19111934

    顯示更多

    收起更多

  • 亞細胞定位：
    [Isoform Soluble]: Cytoplasm.; [Isoform Membrane-bound]: Cell membrane; Single-pass type II membrane protein; Extracellular side.
  • 蛋白家族：
    Class I-like SAM-binding methyltransferase superfamily, Cation-dependent O-methyltransferase family
  • 數據庫鏈接：

    KEGG: rno:24267

    STRING: 10116.ENSRNOP00000043148

    UniGene: Rn.220



主站蜘蛛池模板： 日本熟妇厨房xxxxx乱| 国产高清在线精品一本大道| 国产精品久久久久久爽爽爽床戏| 风韵丰满熟妇啪啪区老老熟女百度| 国产成人综合色就色综合| 亚洲国产成人综合精品| 国产精品无码专区久久久| 久欠精品国国产99国产精2021| 伊人色合天天久久综合网| 亚洲午夜国产精品无码老牛影视 | 亚洲欧美人高清精品a∨| 丰满少妇被猛烈进入试看| 激情内射亚洲一区二区三区爱妻| 色猫咪av在线观看| 精品无码专区久久久水蜜桃| 波多野结衣乳巨码无在线 | 欧美性生交xxxxx久久久| 边啃奶头边躁狠狠躁| 国产传媒麻豆剧精品av国产| 五月色婷婷丁香无码三级| 丰满大肥婆肥奶大屁股| 瑜伽裤国产一区二区三区| 少妇白浆呻吟爽| 97婷婷狠狠成为人免费视频| 啦啦啦www在线观看免费视频| 日韩精品无码一区二区中文字幕| 国产在线码观看清码视频| 亚洲成a人无码| 伊人www22综合色| 色噜噜亚洲男人的天堂| 国内精品伊人久久久久av影院 | 亚洲五月综合缴情在线观看| 特级毛片内射www无码| 亚洲综合无码精品一区二区三区| 久久精品国产9久久综合| 蜜桃麻豆www久久国产sex| 久久久久久成人毛片免费看| 色综合久久中文娱乐网| 无码人妻精品一区二区三区久久 | 狂野欧美激情性xxxx| 国产精品自在线拍国产|