在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Pig Endothelin-1 receptor (EDNRA)

  • 中文名稱:
    野豬EDNRA重組蛋白
  • 貨號:
    CSB-CF644898PI
  • 規(guī)格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產(chǎn)品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    EDNRA; Endothelin-1 receptor; Endothelin receptor type A; ET-A; ET-AR
  • 種屬:
    Sus scrofa (Pig)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區(qū)域:
    21-427
  • 氨基酸序列
    DNPESHSTNLSTHVDDFTTFRGTEFSLVVTTHRPTNLALPSNGSMHNYCPQQTKITSAFK YINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFK LLAGRWPFENHDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPL VTAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEEHKTCMLNATSKFMEFYQDVKDWWLF GFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWF PLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCF QSCLCCCCYQSKSLMTSVPMNGTSIQWKNHEQNNHNTERSSHKDSIN
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.
  • 基因功能參考文獻:
    1. sub-vasomotor concentration of ET-1 leads to vascular dysfunction by impairing endothelium-dependent NO-mediated dilation via p38 kinase-mediated production of superoxide from NADPH oxidase following ETA receptor activation PMID: 26211713
    2. PDE5 inhibition and increase in cGMP produce pulmonary vasodilation that is mediated in part through inhibition of the ET pathway, thereby precluding an additional vasodilator effect of ETA/ETB receptor blockade in the presence of PDE5 inhibition. PMID: 24414253
    3. Blocking ET(A) and ET(B) receptors partially protects sinusoidal circulation and tissue oxygenation against stress induced by high intra-abdominal pressure (IAP). PMID: 22908974
    4. Dual endothelin receptor blockade with tezosentan attenuates hypoxia-induced pulmonary vasoconstriction in porcine model. PMID: 21726419
    5. These results suggest that endothelin released during endotoxemia acts via endothelin A receptors to impair renal medullary blood flow causing ischemia. PMID: 21760895
    6. Anti-endothelin receptor A therapy accelerated the reversal of flow-induced pulmonary arterial disease after flow correction. PMID: 20723731
    7. study suggests a possible role for endothelin-1(resulting from the actions of endothelin-converting enzyme-1) acting via endothelin receptor A in the control of luteolytic sensitivity in the pig PMID: 19783117
    8. Blockade improves renal hemodynamic and function in hypercholesterolemia(HC), and decreases oxidative stress, and renal vascular and tubulointerstitial inflammation and fibrosis. Role for endothelin system in renal injury in HC and atherosclerosis. PMID: 12911546
    9. Results suggest that endothelin A and B receptor protein and mRNA expression is developmentally regulated in the postnatal swine mesenteric artery. PMID: 15240868
    10. Endothelin-A receptor antagonist alters the expression of vasoactive genes and proinflammatory cytokines during hepatic ischemic/reperfusion. PMID: 15838252
    11. Report that inhalation of the endothelin-A receptor antagonist LU-135252 at various doses in experimental acute lung injury improved gas exchange and hemodynamics. PMID: 15838267
    12. ET(A) blockade had no effect on pulmonary vascular resistance at rest or during exercise. PMID: 16709643
    13. PKC and MAPK seem to be involved in the regulation of endothelin type A and type B receptor expression in porcine coronary arteries PMID: 18031734

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family, Endothelin receptor subfamily, EDNRA sub-subfamily
  • 數(shù)據(jù)庫鏈接:


主站蜘蛛池模板: 成年女人免费碰碰视频| 人妻少妇乱子伦无码专区| 中文字幕人妻av一区二区| 国产午夜无码福利在线看网站| 欧美老妇人与禽交| 尤物视频在线观看| 少妇人妻上班偷人精品视频| 男女做爽爽爽视频免费软件| 国产午夜av秒播在线观看| 国模冰莲自慰肥美胞极品人体图| 业余 自由 性别 成熟视频 视频| 人妻av无码系列专区移动可看| 中文字幕制服丝袜第57页| 免费精品99久久国产综合精品| 成人免费看www网址入口| av毛片无码中文字幕不卡| 婷婷五月综合色中文字幕| 亚洲精品无码一区二区| 肉大捧一进一出免费视频| 一本aⅴ高清一区二区三区| 亚洲日韩中文字幕在线播放| 欧美黑人添添高潮a片www| 亚洲综合色丁香婷婷六月图片| 精品国产一二三产品区别在哪| 中文字幕亚洲综合久久青草| 久9视频这里只有精品| 天堂а√在线中文在线新版 | 久久av无码aⅴ高潮av喷吹| 日本亲子乱子伦xxxx50路| 欧洲av无码放荡人妇网站| 国产真人做爰毛片视频直播| 一区二区三区波多野结衣在线观看| 国产亚洲精品岁国产微拍精品| 久久久国产精品| 国产又大又粗又爽的毛片| 无线日本视频精品| 4hu亚洲人成人无码网www电影首页| 亚洲亚洲人成网站网址| 国产成人a区在线观看| 一本加勒比hezyo中文无码| 男女猛烈xx00免费视频试看|