在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Pan troglodytes Mu-type opioid receptor (OPRM1)

  • 中文名稱:
    平頭肌球蛋白OPRM1重組蛋白
  • 貨號:
    CSB-CF702438EQV
  • 規(guī)格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產(chǎn)品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    OPRM1; Mu-type opioid receptor; M-OR-1; MOR-1
  • 種屬:
    Pan troglodytes (Chimpanzee)
  • 蛋白長度:
    full length protein
  • 表達區(qū)域:
    1-401
  • 氨基酸序列
    MDSSAVPANASNCTDDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLC PPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALA TSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALD FRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRHGSIDCTLTFSHPTWYWENLLKICVF IFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIH IYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSN IEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15. They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B. Also couples to adenylate cyclase stimulatory G alpha proteins. The selective temporal coupling to G-proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4. Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization. Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G-protein thus terminating signal transduction. The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins. The activation of the ERK pathway occurs either in a G-protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation. Acts as a class A G-protein coupled receptor (GPCR) which dissociates from beta-arrestin at or near the plasma membrane and undergoes rapid recycling. Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G-protein coupling. Endogenous ligands induce rapid desensitization, endocytosis and recycling. Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties. Involved in neurogenesis.
  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein. Cell projection, axon. Perikaryon. Cell projection, dendrite. Endosome.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 數(shù)據(jù)庫鏈接:


主站蜘蛛池模板: 久久人人爽人人爽人人片| 又湿又黄裸乳漫画无遮挡网站| 大香伊蕉在人线国产最新75| 国产亚洲999精品aa片在线爽| 成年轻人网站色直接看| 手机在线看永久av片免费| 99精品久久毛片a片| 伊人色综合久久天天| 国产成人亚洲综合青青| 亚洲色成人影院在线观看| 日本免费一区二区三区视频观看 | 国产精品无码电影在线观看| 中国少妇初尝黑人巨高清| 欧美成人高清视频a在线看| 67194熟妇在线观看线路1 | 隔壁老王国产在线精品| 秋霞最新高清无码鲁丝片| 日本一卡二卡3卡四卡网站精品 | 久久无码人妻影院| 国产精品不卡无码av在线播放 | 一区二区三区波多野结衣在线观看 | 加勒比一本heyzo高清视频| 人人做人人爽国产视| 久久一卡二卡三卡四卡| 日本熟妇人妻xxxx| 柠檬福利精品视频导航| 亚洲国产精品av在线播放| 日本免费一区二区三区| 人妻丰满熟妞av无码区| 色综合天天无码网站| 久久996re热这里有精品| 成年女人永久免费观看视频| 国产精品永久免费视频| 亚洲大成色www永久网站动图| 韩国无码av片在线观看网站| 色婷婷美国农夫综合激情亚洲 | 西西444www大胆无码视频| 亚洲午夜福利精品无码不卡| 国产av熟女一区二区三区| 无码人妻品一区二区三区精99| 2020久久超碰国产精品最新|