在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse p53 apoptosis effector related to PMP-22 (Perp)

  • 中文名稱:
    小鼠Perp重組蛋白
  • 貨號(hào):
    CSB-CF872865MO
  • 規(guī)格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產(chǎn)品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    Perp; Krtcap1; p53 apoptosis effector related to PMP-22; Keratinocyte-associated protein 1; KCP-1
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度:
    full length protein
  • 表達(dá)區(qū)域:
    1-193
  • 氨基酸序列
    MLRCGLACERCRWILPLLLLSAIAFDIIALAGRGWLQSSNHIQTSSLWWRCFDEGGGSGS YDDGCQSLMEYAWGRAAAATLFCGFIILCICFILSFFALCGPQMLVFLRVIGGLLALAAI FQIISLVIYPVKYTQTFRLHDNPAVNYIYNWAYGFGWAATIILIGCSFFFCCLPNYEDDL LGAAKPRYFYPPA
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway.
  • 基因功能參考文獻(xiàn):
    1. Perp might play important roles in the formation and integration of stellate reticulum, dental lamina structure and enamel formation PMID: 24865245
    2. an important role for Perp in normal mammary tissue function and in mammary cancer suppression PMID: 22515648
    3. Data show that PERP is necessary for the integrity of the ameloblast-SI interface and that a lack of Perp causes downregulation of genes that are required for proper enamel formation. PMID: 21285247
    4. Studies suggest that Perp-deficiency promotes cancer by enhancing cell survival, desmosome loss, and inflammation, and they highlight a fundamental role for Perp and desmosomes in tumor suppression. PMID: 20975948
    5. In contrast to p53 shRNAs, PUMA shRNAs were unable to cooperate with oncogenic ras in transformation PMID: 15192153
    6. Perp is a key effector in the p63 developmental program. PMID: 15797384
    7. Perp is required for efficient skin carcinogenesis and suggest a role for intact cell-cell adhesion in supporting tumor development in these settings. PMID: 16061634
    8. Perp's requirement for both viability and epithelial integrity reflects a role in the stratified epithelial compartment. PMID: 16417219
    9. Perp is requered throughout adult life for proper epithelial homeostasis and function. PMID: 16485031
    10. pemphigus vulgaris autoantibodies disrupt Perp expression at the membrane and trigger its internalization along with DSG3 into the endosomal pathway, where it is ultimately targeted to the lysosome for degradation PMID: 19158843
    11. A paper describing the identification of Perp (p53 Apoptosis Effector Related to PMP22). Perp was found as a novel target gene of the p53 tumor suppressor, which is selectively induced during apoptosis compared to cell cycle arrest. PMID: 10733530

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cell junction, desmosome. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    TMEM47 family
  • 組織特異性:
    Expressed in the stratified squamous skin epithelium of the skin and the tongue, but not in simple epithelia (at protein level). Expressed in apoptotic cells.
  • 數(shù)據(jù)庫(kù)鏈接:


主站蜘蛛池模板: 国产狂喷潮在线观看| 麻豆ā片免费观看在线看| 国产成人无码免费看片软件| av无码免费岛国动作片不卡| www亚洲精品久久久乳| 人妻少妇久久久久久97人妻| 一区二区三区四区在线不卡高清| 色欲aⅴ亚洲情无码av蜜桃| 5566先锋影音夜色资源站在线观看| 国精产品48x国精产品| 国产精品狼人久久久久影院| 超碰97人人射妻| 欧洲av无码放荡人妇网站| 97超碰国产精品无码分类| 丝袜老师办公室里做好紧好爽| 亚洲国产精品一区二区成人片| 乱子伦av无码中文字| 18禁止进入1000部高潮网站| 国产成人艳妇aa视频在线| 女人被男人躁得好爽免费视频| 一本aⅴ高清一区二区三区| 国产日产精品久久快鸭的功能介绍| 久久午夜无码鲁丝片午夜精品| 日本丰满老妇bbw| 免费人成在线观看成人片| 国产精品久久久久9999小说| 后入内射无码人妻一区| 国产新婚夫妇叫床声不断| 国产成人高清精品免费| 国产手机在线国内精品| 无码人妻aⅴ一区二区三区| 亚洲欧洲日产国码无码| 无码少妇一区二区三区浪潮av| 免费观看激色视频网站| a片免费视频在线观看| 精品国产污污免费网站入口| 久久精品日韩av无码| 国产综合有码无码中文字幕| 中国少妇初尝黑人巨高清| 成年无码动漫av片在线尤物| 妺妺窝人体色www聚色窝仙踪|