在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse p53 apoptosis effector related to PMP-22 (Perp)

  • 中文名稱:
    小鼠Perp重組蛋白
  • 貨號(hào):
    CSB-CF872865MO
  • 規(guī)格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產(chǎn)品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    Perp; Krtcap1; p53 apoptosis effector related to PMP-22; Keratinocyte-associated protein 1; KCP-1
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度:
    full length protein
  • 表達(dá)區(qū)域:
    1-193
  • 氨基酸序列
    MLRCGLACERCRWILPLLLLSAIAFDIIALAGRGWLQSSNHIQTSSLWWRCFDEGGGSGS YDDGCQSLMEYAWGRAAAATLFCGFIILCICFILSFFALCGPQMLVFLRVIGGLLALAAI FQIISLVIYPVKYTQTFRLHDNPAVNYIYNWAYGFGWAATIILIGCSFFFCCLPNYEDDL LGAAKPRYFYPPA
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway.
  • 基因功能參考文獻(xiàn):
    1. Perp might play important roles in the formation and integration of stellate reticulum, dental lamina structure and enamel formation PMID: 24865245
    2. an important role for Perp in normal mammary tissue function and in mammary cancer suppression PMID: 22515648
    3. Data show that PERP is necessary for the integrity of the ameloblast-SI interface and that a lack of Perp causes downregulation of genes that are required for proper enamel formation. PMID: 21285247
    4. Studies suggest that Perp-deficiency promotes cancer by enhancing cell survival, desmosome loss, and inflammation, and they highlight a fundamental role for Perp and desmosomes in tumor suppression. PMID: 20975948
    5. In contrast to p53 shRNAs, PUMA shRNAs were unable to cooperate with oncogenic ras in transformation PMID: 15192153
    6. Perp is a key effector in the p63 developmental program. PMID: 15797384
    7. Perp is required for efficient skin carcinogenesis and suggest a role for intact cell-cell adhesion in supporting tumor development in these settings. PMID: 16061634
    8. Perp's requirement for both viability and epithelial integrity reflects a role in the stratified epithelial compartment. PMID: 16417219
    9. Perp is requered throughout adult life for proper epithelial homeostasis and function. PMID: 16485031
    10. pemphigus vulgaris autoantibodies disrupt Perp expression at the membrane and trigger its internalization along with DSG3 into the endosomal pathway, where it is ultimately targeted to the lysosome for degradation PMID: 19158843
    11. A paper describing the identification of Perp (p53 Apoptosis Effector Related to PMP22). Perp was found as a novel target gene of the p53 tumor suppressor, which is selectively induced during apoptosis compared to cell cycle arrest. PMID: 10733530

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cell junction, desmosome. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    TMEM47 family
  • 組織特異性:
    Expressed in the stratified squamous skin epithelium of the skin and the tongue, but not in simple epithelia (at protein level). Expressed in apoptotic cells.
  • 數(shù)據(jù)庫(kù)鏈接:


主站蜘蛛池模板: 午夜男女无遮掩免费视频| 日本少妇寂寞少妇aaa| 精品一卡2卡三卡4卡乱码精品视频| 日本高清二区视频久二区| 久久精品国产久精久精| 小鲜肉自慰网站| 成人欧美一区二区三区黑人 | 天天av天天爽无码中文| 2021年国产精品专区丝袜 | 亚洲熟女综合一区二区三区| 性色欲情网站| 日本欧美亚洲中文在线观看| 欧美野性肉体狂欢大派对| 国产美女自慰在线观看| 国产午夜无码视频在线观看| 9九色桋品熟女内射| 四虎亚洲精品高清在线观看| 在线观看片免费人成视频无码| 亚洲人成色777777老人头| 欧美日韩一区二区成人午夜电影 | 国产免费内射又粗又爽密桃视频| 18禁黄无遮挡网站免费| 久久久久久伊人高潮影院| 国产精品99久久久久久宅男小说| 国产午夜精品一区二区三区四区 | 欧美最猛黑人xxxxx猛交| www国产精品内射熟女| 影音先锋男人站| 人人妻人人爽人人做夜欢视频九色| 忘忧草影院在线www韩国日本 | 一本一道久久综合狠狠老 | 又色又爽又黄的吃奶视频免费观看| 蜜臀av片在线观看| 玩两个丰满老熟女| 美女内射毛片在线看免费人动物| 四虎影视精品永久在线观看| 又黄又湿啪啪响18禁| 国产精品厕所| 老熟妇仑乱一区二区视頻| 久久久无码精品午夜| 精品999日本久久久影院|