在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Solute carrier family 22 member 3 (Slc22a3)

  • 中文名稱:
    小鼠Slc22a3重組蛋白
  • 貨號:
    CSB-CF892978MO
  • 規(guī)格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產(chǎn)品詳情

  • 基因名:
    Slc22a3
  • Uniprot No.:
  • 別名:
    Slc22a3; Oct3; Solute carrier family 22 member 3; Organic cation transporter 3
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    full length protein
  • 表達(dá)區(qū)域:
    1-551
  • 氨基酸序列
    MPTFDQALRKAGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGSQPDYYWCRGPRATALA ERCAWSPEEEWNLTTPELHVPAERRGQGHCHRYLLEATNTSSELSCDPLTAFPNRSAPLV SCSGDWRYVETHSTIVSQFDLVCSNAWMLDLTQAILNLGFLAGAFTLGYAADRYGRLIIY LISCFGVGITGVVVAFAPNFSVFVIFRFLQGVFGKGAWMTCFVIVTEIVGSKQRRIVGIV IQMFFTLGIIILPGIAYFTPSWQGIQLAISLPSFLFLLYYWVVPESPRWLITRKQGEKAL QILRRVAKCNGKHLSSNYSEITVTDEEVSNPSCLDLVRTPQMRKCTLILMFAWFTSAVVY QGLVMRLGLIGGNLYIDFFISGLVELPGALLILLTIERLGRRLPFAASNIVAGVSCLVTA FLPEGIPWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAP FLLFRLAAIWLELPLIIFGILASVCGGLVMLLPETKGIALPETVEDVEKLGSSQLHQCGR KKKTQVSTSDV
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.
  • 基因功能參考文獻(xiàn):
    1. Study is the first to examine the subcellular localization of organic cation transporter 3 (OCT3) in any tissue, and the first to explore its spatial relationship to synaptic structures in the brain. Study suggests that OCT3 not only contributes to the clearance of extracellular monoamines, but also plays a role in their intracellular disposition and action. PMID: 27659446
    2. Metformin undergoes negligible metabolism, these results imply that intestinal absorption of metformin is mediated at least in part by Oct3 in mice. PMID: 27569291
    3. Study showed that few, if any, 5-HT neurons in the dorsal raphe are resistant to loss of Pet-1 for expression of Slc22a3 PMID: 25642596
    4. Findings suggest that OCT3 plays an important role in the absorption and elimination of metformin and that the transporter is a critical determinant of metformin bioavailability, clearance, and pharmacologic action. PMID: 25920679
    5. These results demonstrate that OCT3 is responsible for metformin accumulation and secretion in salivary glands. PMID: 25107910
    6. evidence for a new means of downregulating IL-4 production by basophils, both in vitro and in vivo, through OCT3 targeted by 5-HT and pharmacologic ligands. PMID: 21636115
    7. these results show that reduced 5-HT clearance following HPA axis activation is likely mediated, at least in part, by the corticosterone-sensitive OCT3 PMID: 21068324
    8. Slc22a3 is one of three imprinted genes on chromosome 17 that is expressed from the maternal allele. A non-coding Air RNA is required for repression of all three genes on the paternal allele. PMID: 11845212
    9. In 5HT transporter-deficient mice, OCT3 mRNA concentrations were significantly increased in the hippocampus, but not in other brain regions PMID: 12584728
    10. Imprinted silencing of Slc22a3 does not need transcriptional overlap between Igf2r and Air. PMID: 12853484
    11. OCT3 is critical for the balanced neural and behavioral responses to environmentally induced variations in osmolarity and important for CNS function PMID: 15028779
    12. STAT3 and Oct3/4, essential transcription factors for ES cell self-renewal, are involved in the regulation of Dax1 expression. PMID: 18471437
    13. OCT3 plays a role in the homeostatic regulation of aminergic neurotransmission in the brain. PMID: 18513366
    14. findings show Air interacts with the Slc22a3 promoter chromatin & the H3K9 histone methyltransferase G9a in placenta; Air accumulates at the Slc22a3 promoter in correlation with localized H3K9 methylation & transcriptional repression PMID: 18988810
    15. Results suggest that organic cation transporter type 3 may be an important transporter mediating serotonergic signaling when serotonin transporter expression or function is compromised. PMID: 19033200
    16. a role of OCT3 in the regulation of fear and anxiety PMID: 19280114

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Major facilitator (TC 2.A.1) superfamily, Organic cation transporter (TC 2.A.1.19) family
  • 組織特異性:
    Highly expressed in placenta and in kidney cortex, but not in medulla. Low levels found in brain. In the kidney, expressed specifically in the proximal and distal convoluted tubules and within Bowman capsule, but not in the glomerulus.
  • 數(shù)據(jù)庫鏈接:


主站蜘蛛池模板: 在线精品无码字幕无码av| 免费观看激色视频网站| 天天综合亚洲色在线精品| 日日摸日日碰夜夜爽免费| 97免费人妻在线视频| 乱子伦视频在线看| 老司机午夜免费精品视频| 99精品视频一区在线观看| 少妇人妻精品无码专区视频| gv天堂gv无码男同在线观看| 无码少妇一区二区| 国产做爰xxxⅹ高潮视频12p| 亚洲v国产v天堂a无码二区| 亚洲人成人无码www影院| 欧美偷窥清纯综合图区| 无码尹人久久相蕉无码| 国精品人妻无码一区二区三区性色| 人人添人人澡人人澡人人人人 | 欧美精品18videosex性欧| 国模国产精品嫩模大尺度视频| 国产中的精品av一区二区| 国产成人综合在线视频| 性人久久网av| 国产色青青视频在线观看撒| 亚洲色无码中文字幕在线| 欧洲熟妇精品视频| 国产av夜夜欢一区二区三区| 337p日本大胆欧久久| 国产免码va在线观看免费| 综合无码一区二区三区| 国产高清午夜人成在线观看 | 裸体丰满白嫩大尺度尤物| 欧美亚洲综合在线一区| 国产精品久久久久久亚洲影视| 亚洲欧美日韩中文二区| 无遮挡边吃摸边吃奶边做| 国精品无码人妻一区二区三区| 国产精品国语对白露脸在线播放| 国产av综合第一页| 精品深夜av无码一区二区| 亚洲欧美日韩久久一区二区|