在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Psychosine receptor (Gpr65)

  • 中文名稱:
    小鼠Gpr65重組蛋白
  • 貨號(hào):
    CSB-CF736801MO
  • 說明書:
  • 規(guī)格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產(chǎn)品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    Gpr65; Gpcr25; Tdag8; Psychosine receptor; G-protein coupled receptor 65; T-cell death-associated gene 8 protein
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    full length protein
  • 表達(dá)區(qū)域:
    1-337
  • 氨基酸序列
    MAMNSMCIEEQHHLEHYLFPVVYIIVFIVSVPANIGSLCVSFLQAKKENELGIYLFSLSL SDLLYALTLPLWINYTWNKDNWTFSPTLCKGSVFFTYMNFYSSTAFLTCIALDRYLAVVY PLKFSFLRTRRFAFITSLSIWILESFFNSMLLWKDETSVEYCDSDKSNFTLCYDKYPLEK WQINLNLFRTCMGYAIPLITIMICNHKVYRAVRHNQATENSEKRRIIKLLASITLTFVLC FTPFHVMVLIRCVLERDMNVNDKSGWQTFTVYRVTVALTSLNCVADPILYCFVTETGRAD MWNILKLCTRKHNRHQGQKRDILSVSTRDAVELEIID
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids. Plays a role in immune response by maintaining lysosome function and supporting phagocytosis-mediated intracellular bacteria clearance. May have a role in activation-induced cell death or differentiation of T-cells.
  • 基因功能參考文獻(xiàn):
    1. TDAG8 may mediate acidosis signals to initiate inflammatory hyperalgesia and establish hyperalgesic priming. PMID: 28145512
    2. data identify TDAG8-dependent microglial acid sensing as a unique chemosensor for detecting and translating hypercapnia to fear-associated behavioral and physiological responses. PMID: 27422366
    3. TDAG8 is a negative regulator for lung neutrophilic inflammation and injury, in part, through the inhibition of chemokine production. PMID: 26690120
    4. TDAG8(-/-) mice showed significantly higher consumption of sucrose compared to wild type mice although sucrose preference was not significantly different between genotypes. PMID: 25770699
    5. The results of this study indicated that the proton-sensing G protein-coupled receptor GPR65 may be involved in a mechanism that supports survival of photoreceptors in the degenerating retina. PMID: 26117715
    6. This study demonstrates differential regulation of eosinophils and mast cells in inflammatory tissue, with mast cell viability and accumulation being independent of GPR65. PMID: 24742990
    7. IL-1beta mRNA and protein were attenuated in microglia from TDAG8-deficient mice. TDAG8/PKA signaling inhibits LPS-induced ERK and JNK. This inhibits IL-1beta production. TDAG8 may mediate the proton-induced inhibition of LPS-induced cytokine production. PMID: 24447140
    8. Results suggest that the enhancement of TDAG8 function represents a new strategy for preventing bone resorption diseases, such as osteoporosis. PMID: 24221084
    9. Acidosis promotes Bcl-2 family-mediated evasion of apoptosis: involvement of acid-sensing G protein-coupled receptor Gpr65 signaling to Mek/Erk. PMID: 22685289
    10. Data suggest that one physiological function of TDAG8 is negative regulation of inflammation by inhibiting production of pro-inflammatory cytokines in T-lymphocytes, macrophages, and splenocytes. PMID: 22445881
    11. TDAG8 is involved in the GC-induced anti-inflammatory actions in macrophages. PMID: 22074830
    12. TDAG8 acts as a negative regulator of inflammation PMID: 21238451
    13. These results support the hypothesis that TDAG8 enhances tumor development by promoting adaptation to the acidic environment to enhance cell survival/proliferation. PMID: 20855608
    14. TDAG8 is one of the proton-sensing GPCRs coupling to adenylyl cyclase and psychosine, and its related lysosphingolipids behave as if they were antagonists against protein-sensing receptors, including TDAG8, GPR4, and OGR1. PMID: 15326175
    15. TDAG8 is a regulator of glucocorticoid-induced apoptosis PMID: 15485889
    16. There is no a critical role for TDAG8 in immune development, psychosine-mediated inhibition of cytokinesis, and GC-induced cell death. PMID: 16382156
    17. gene expression of proton-sensing GPCRs is changed in ASIC3 knockout mice. PMID: 17720533
    18. Eosinophil viability is increased in acidic microenvironments in a cAMP- and GPR65-dependent manner. PMID: 19641187

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 組織特異性:
    Detected in thymus and at low levels in spleen.
  • 數(shù)據(jù)庫鏈接:


主站蜘蛛池模板: 国产成人久久精品二区三区| 日韩精品少妇无码受不了| 国模雨珍浓密毛大尺度150p| 亚洲综合天堂av网站在线观看| 高清一区二区三区日本久| 亚洲乱码无人区卡1卡2卡3| 亚洲精品国产美女久久久99| 草草浮力地址线路①屁屁影院| 国产黄a三级三级三级av在线看| 九九精品成人免费国产片| 2021最新国产在线人成| 国产成人久久av免费| 久久精品aⅴ无码中文字字幕重口| 欧美性猛交xxxx富婆| 欲香欲色天天综合久久| 十八禁av无码免费网站| 亚洲最大天堂无码精品区| 国产午夜亚洲精品不卡| 亚洲国产日韩一区三区| 97人妻无码专区| 最新国产麻豆aⅴ精品无码| 一本色道久久综合亚洲精品 | 日韩人妻ol丝袜av一二区| 国产成人av男人的天堂| 美女内射毛片在线看免费人动物| 亚洲中文字幕永久在线不卡| 亚洲成av人片高潮喷水| 性xxxx18免费观看视频| 日本强伦姧人妻一区二区| 西西人体大胆扒开下部337卩| 久久久久久人妻精品一区| 亚洲欧美日韩国产精品一区二区 | 久久亚洲精品中文字幕一区| 色av专区无码影音先锋| 亚洲中文字幕无码爆乳| av无码东京热亚洲男人的天堂| 国产成人无码av大片大片在线观看 | 色窝窝免费播放视频在线| 久久精品国产99精品国产亚洲性色| 亚洲国产精品久久网午夜| 午夜福制92视频|