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Recombinant Mouse Protein CLN8 (Cln8)

  • 中文名稱:
    Recombinant Mouse Protein CLN8(Cln8)
  • 貨號:
    CSB-CF882535MO
  • 規(guī)格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產(chǎn)品詳情

  • 基因名:
    Cln8
  • Uniprot No.:
  • 別名:
    Cln8; Protein CLN8
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    full length protein
  • 表達區(qū)域:
    1-288
  • 氨基酸序列
    MTPVSSHGLAESIFDLDYASWKIRSTLAVAGFVFYLGVFVVCHQLSSSLNATYRSLAAKE KVFWNLAATRAVFGVQSTTAGLWALLGDPVLYADKALGQQNWCWFHITTATGFFFFENVA VHLSNLFFRTFDLFLVVHHLFAFLGFLGSAINLRAGHYLAMTTLLLEMSTPFTCISWMLL KAGWSDSLFWKANQWLMIHMFHCRMILTYHMWWVCFCHWDALTSSLHLPHWALFLFGLAL LTAVINPYWTHKKTQQLLHPVDWNFAQEEAKGSRQERTNGQVPRKKRL
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Could play a role in cell proliferation during neuronal differentiation and in protection against cell death.
  • 基因功能參考文獻:
    1. This study demonistrated that Selective spatiotemporal patterns of glial activation and neuron loss in the sensory thalamocortical pathways in neuronal ceroid lipofuscinosis 8 decifiency mice. PMID: 22569358
    2. The amount of myelin was reduced in 1-month-old Cln8(mnd) mice, but reached normal levels by 5 months of age. The level of Cln8 gene expression followed the developmental pattern of myelin formation and was high in primary oligodendrocytes. PMID: 22044361
    3. This study demonistrated that the changes in glutamate receptor expression in the hippocampus of the mnd mouse. PMID: 22302580
    4. Mutations in mouse CLN8 gene show marked deficiency of mitochondrial Ca2+ clearance in Cln8mnd neurons, and the heightened vulnerability of these neurons to excitotoxic effects of glutamate. PMID: 21917311
    5. The mnd mouse mutation in CLN8 leads to progressive behavioral abnormalities prior to the onset of gross motor symptoms, linking the mutation via pathology to a quantifiable behavioral phenotype. PMID: 12020865
    6. A marked increase in astroglial and microglial cells, and in TNF receptor TNFR-I immunoreactivity was observed in the spinal cord of motor neuron degeneration mutation (mnd) mice at the age of 4 month. PMID: 14698139
    7. Mutations in the CLN8 gene underlie Northern epilepsy and a subset of Turkish variant late infantile NCL. Inducing disease mutations in a mouse hippocampal neuronal cell line did not affect localization of CLN8. PMID: 15160397
    8. Expression of Cln8 in the developing and mature brain suggests roles for Cln8 in maturation, differentiation and supporting the survival of different neuronal populations. PMID: 15826318

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  • 相關疾病:
    Defects in Cln8 are the cause of the phenotype motor neuron degeneration (mnd). Mnd is a naturally occurring mutant It is characterized by progressive motor system degeneration. It has intracellular autofluorescent inclusions similar to those seen in human Cln8.
  • 亞細胞定位:
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Endoplasmic reticulum.
  • 數(shù)據(jù)庫鏈接:


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