在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Lactosylceramide alpha-2,3-sialyltransferase (St3gal5)

  • 中文名稱:
    小鼠St3gal5重組蛋白
  • 貨號:
    CSB-CF022755MO
  • 說明書:
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
    St3gal5
  • Uniprot No.:
  • 別名:
    St3gal5; GM3S; Siat9; Lactosylceramide alpha-2,3-sialyltransferase; CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase; Ganglioside GM3 synthase; ST3Gal V; ST3GalV; Sialyltransferase 9
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-414
  • 氨基酸序列
    MHTEAVGGAARRPQKLRSQAAAPACRAMPSEFTSAKLRSDCSRTSLQWYTRTQHKMRRPSLLIKDICKCTLVAFGVWLLYILILNYTAEECDMKRMHYVDPDRIKRAQSYAQEVLQKECRPRYAKTAMALLFEDRYSINLEPFVQKVPTASEAELKYDPPFGFRKFSSKVQSLLDMLPEHDFPEHLRAKACKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDVEYYANDLFVTVLFKSVDFKWLQAMVKNESLPFWVRLFFWKQVAEKVPLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGHDKNIPTIGVIAVVLATHLCDEVSLAGFGYDLSQPRTPLHYFDSQCMGAMHWQVMHNVTTETKFLLKLLKEGVVEDLSGGIH
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Gangliosides GD1b and GT1b (derived from GM3) may serve as receptors for some C.botulinum neurotoxins (minimally types BoNT/A, B, C).; Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the non-reducing terminal galactose (Gal) of glycosphingolipids forming gangliosides (important molecules involved in the regulation of multiple cellular processes, including cell proliferation and differentiation, apoptosis, embryogenesis, development, and oncogenesis). Mainly involved in the biosynthesis of ganglioside GM3 but can also use different glycolipids as substrate acceptors such as D-galactosylceramide (GalCer), asialo-GM2 (GA2) and asialo-GM1 (GA1), although less preferentially than beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer (LacCer).
  • 基因功能參考文獻:
    1. A new liver-specific c-type mRNA transcriptional variant of mouse ST3GAL5 protein has been identified. PMID: 28808804
    2. We used GM2/GD2 synthase (B4galnt1)-deficient mice to immunize by liposomes embedded with GD1alpha or acidic glycolipid fractions from brain of St3gal5-deficient mice. Specificities of established mAbs as analyzed by enzyme-linked immunosorbent assay and thin-layer chromatography-immunostaining were very high among various gangliosides. PMID: 27102283
    3. These studies establish ganglioside GM3 as a new candidate responsible for neuropathic pain and small fiber neuropathy in diabetes. PMID: 27590073
    4. R/K-based motif is necessary for the Golgi retention of ST3G5 . PMID: 26362868
    5. Functionally, the repression of St3gal5 suffices to elevate intercellular adhesion and expression of distinct junction-associated proteins, reminiscent of knockdown of Zeb1. PMID: 25643708
    6. ganglioside GM3 synthase has a role in siRNA-based spherical nucleic acid reversal of impaired wound healing in diabetic mice PMID: 25902507
    7. Results show that complete and partial deletion of the GM3 synthase gene exert distinct effects on the NP-C (Niemann-Pick disease Type C) phenotype. PMID: 24599001
    8. genes involved in the sphingolipids metabolism may be modifiers of cystogenesis, and suggest GM3 synthase as a new anti-cystic therapeutic target. PMID: 22563011
    9. Results suggest that complete, but not partial, inhibition of GM3 synthesis results in robust activation of an alternate pathway that may compensate for the complete absence of the products of GM3 synthase. PMID: 17604219
    10. the age at death of the npc1(-/-) mouse can be significantly influenced by many factors, including differences in strain background, other inactivating gene mutations in Siat9 and lxrbeta PMID: 18077828
    11. GM3 synthase silencing suppressed lung metastasis in murine breast cancer cells. The molecular mechanism that underlies GM3 synthase mediated migration and invasion was inhibition of the phosphoinositide-3 kinase/Akt pathway. PMID: 18171481
    12. Data show that M1-SAT-I and M3-SAT-I had a long half-life relative to M2-SAT-I. PMID: 19420140
    13. The defect of hearing ability of GM3 synthase null mice could be attributed to the functional disorganization of the organ of Corti, and the expression of gangliosides, especially GM3, during the maturation of the cochlea. PMID: 19470479
    14. zST3GalV-2 and mST3GalV are the enzymes responsible for the synthesis of GM4 in zebrafish and mice, respectively. PMID: 19542236

    顯示更多

    收起更多

  • 亞細胞定位:
    Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族:
    Glycosyltransferase 29 family
  • 組織特異性:
    Mainly expressed in brain, and then testis, heart and liver, almost all tissues showed some levels of the gene expression.
  • 數據庫鏈接:


主站蜘蛛池模板: 护士的小嫩嫩好紧好爽| 激情综合婷婷丁香五月| 精品国产乱码久久久久夜深人妻| 婷婷久久香蕉五月综合| 色视频无码专区在线观看| 亚洲国产中文在线视频| 中文字幕人妻无码视频| 日本不卡三区| 久久亚洲色www成人男男| 国产欧美亚洲日韩图片| 中文字幕人妻中文av不卡专区| 亚洲精品乱码久久久久久| 欧美性生交活xxxxxdddd| 欧美人与动牲交免费观看| 精品国产一区二区三区四区阿崩| 香港三日本8a三级少妇三级99| 亚洲色自偷自拍另类小说| 午夜免费无码福利视频| 老熟妇性老熟妇性色| 精品亚洲一区二区三区在线观看| 麻豆精品一卡二卡三卡| 在线a毛片免费视频观看| 天天av天天翘天天综合网| 无码一区二区三区中文字幕| 一本av高清一区二区三区| 强行从后面挺进人妻| 国产麻豆成人传媒免费观看| 国产一区二区野外| 无码国产精成人午夜视频| 亚洲视频一区| 国产亚洲人成a在线v网站| 日本午夜精品一区二区三区电影| 婷婷色五月开心五月| 色老板精品视频在线观看| 一群黑人大战亚裔女在线播放| 成在人线av无码免费看网站 | 中文字幕无码精品亚洲资源网| a在线视频v视频| 成人欧美一区二区三区在线观看| 国产免费人成在线视频网站| 国产99视频精品免视看7|