在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Frizzled-7 (Fzd7)

  • 中文名稱:
    小鼠Fzd7重組蛋白
  • 貨號:
    CSB-CF730721MO
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    Fzd7; Frizzled-7; Fz-7; mFz7
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    33-572
  • 氨基酸序列
    QPYHGEKGISVPDHGFCQPISIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKV QCSPELRFFLCSMYAPVCTVLDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFP VHGAGEICVGQNTSDGSGGAGGSPTAYPTAPYLPDPPFTAMSPSDGRGRLSFPFSCPRQL KVPPYLGYRFLGERDCGAPCEPGRANGLMYFKEEERRFARLWVGVWSVLSCASTLFTVLT YLVDMRRFSYPERPIIFLSGCYFMVAVAHVAGFLLEDRAVCVERFSDDGYRTVAQGTKKE GCTILFMVLYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTI TILAMGQVDGDLLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIM KHDGTKTEKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWERTWLLQTCKSYAVP CPPRHFSPMSPDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHRLSHSSKGETAV
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by WNT8 induces expression of beta-catenin target genes. Following ligand activation, binds to CCDC88C/DAPLE which displaces DVL1 from FZD7 and leads to inhibition of canonical Wnt signaling, activation of G-proteins by CCDC88C and triggering of non-canonical Wnt responses. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
  • 基因功能參考文獻:
    1. these data provide functional evidence of a crucial role for Wnt signalling, via the Fzd7 receptor, during homeostasis of the gastric epithelium. PMID: 28600348
    2. FZD7 transmits non-canonical Wnt signaling by interacting Wnt5A in the regulation of extracellular matrix expression. PMID: 28736081
    3. Fzd7 is enriched in Lgr5(+) stem cells and binds Wnt3 and Wnt2b. PMID: 25892522
    4. the Wnt receptor, frizzled-7, is a downstream target of miR-184, and delivery of miR-184 mimic inhibits Wnt signaling in the OIR retina. PMID: 25796186
    5. Fzd7 is a new partner of adherens junctional complex and represents a novel molecular switch for the control of vascular permeabilityvia activation of the Wnt-canonical pathway PMID: 24866384
    6. observed genetic interactions between Fz2 and Fz7 and five canonical and/or non-canonical signaling molecules: Dvl3, Wnt3a, Wnt11, Vangl2, and Wnt5a PMID: 23095888
    7. Data show that the Fzd7 receptor complex was associated with Galpha(s) and PI(3)K and these components were required for Wnt7a to activate the Akt/mTOR growth pathway in myotubes. PMID: 22179044

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor Fz/Smo family
  • 數據庫鏈接:


主站蜘蛛池模板: 精品第一国产综合精品蜜芽| 国产免费视频| 无码专区天天躁天天躁在线| 小12萝裸体自慰出白浆| 97色成人综合网站| 亚洲一区二区三区无码影院| 免费大片黄在线观看| 久久精品人妻少妇一区二区三区| 国产亚洲人成a在线v网站| 无套熟女av呻吟在线观看| 久久久亚洲欧洲日产无码av| 日韩视频 中文字幕 视频一区| 小说区 图片区色 综合区| 精品偷自拍另类在线观看| 亚洲无日韩码精品| 国产大陆亚洲精品国产| 爆乳熟妇一区二区三区霸乳| 国产边摸边吃奶边做爽视频| 欧美成aⅴ人高清免费观看| 青草青草视频2免费观看| 99国产精品白浆在线观看免费| 青青青青国产免费线在线观看| 日本乱码一区二区三区不卡| 少妇人妻偷人精品无码视频| 国产成人无码免费视频在线| 少妇性荡欲视频| 99久久人人爽亚洲精品美女| 日本伊人色综合网| 永久免费观看黄网视频| 午夜精品射精入后重之免费观看| 久久综合噜噜激激的五月天| 亚洲一区无码中文字幕乱码| 久久www成人片免费看| 成人区人妻精品一区二区不卡网站| 国产麻豆9l精品三级站| 真人做人60分钟啪啪免费看| 国产亚洲日韩在线a不卡| 伊人久久大香线蕉综合网站| 亚洲中文无码人a∨在线导航| 92精品成人国产在线观看| 夜夜躁狠狠躁日日躁|