在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Free fatty acid receptor 3 (Ffar3)

  • 中文名稱:
    小鼠Ffar3重組蛋白
  • 貨號:
    CSB-CF008606MO
  • 規(guī)格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產(chǎn)品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    Ffar3; Gm478; Gpr41; Free fatty acid receptor 3; G-protein coupled receptor 41
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    full length protein
  • 表達區(qū)域:
    1-319
  • 氨基酸序列
    MGTSFFLGNYWLFFSVYLLVFLVGLPLNVMALVVFVGKLRRRPVAVDLLLLNLTISDLLL LLFLPFRMVEAACGMRWLLPFIFCPLSGFLFFTTIYLTSLFLTAVSIERFLSVAYPLWYK TRPRLAQAGLVSVVCWFLASAHCSVVYITEYWGNATYSQGTNGTCYLEFREDQLAILLPV RLEMAVVLFMVPLCITSYCYSRLVWILSRGASRRRRKRIMGLLAATLLIFFVCFGPYNMS HVVGYVSRESPSWRSYVLLLSTLNSCIDPLVFYFSSSKFQADFHQLLGRLLRTCVPWTQQ VSLELKVKNGEEPSKECPS
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins. Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. Activated by SCFAs and by beta-hydroxybutyrate, a ketone body produced by the liver upon starvation, it inhibits N-type calcium channels and modulates the activity of sympathetic neurons through a signaling cascade involving the beta and gamma subunits of its coupled G protein, phospholipase C and MAP kinases. Thereby, it may regulate energy expenditure through the control of the sympathetic nervous system that controls for instance heart rate. Upon activation by SCFAs accumulating in the intestine, it may also signal to the brain via neural circuits which in turn would regulate intestinal gluconeogenesis. May also control the production of hormones involved in whole-body energy homeostasis. May for instance, regulate blood pressure through renin secretion. May also regulate secretion of the PYY peptide by enteroendocrine cells and control gut motility, intestinal transit rate, and the harvesting of energy from SCFAs produced by gut microbiota. May also indirectly regulate the production of LEP/Leptin, a hormone acting on the CNS to inhibit food intake, in response to the presence of short-chain fatty acids in the intestine. Finally, may also play a role in glucose homeostasis. Besides its role in energy homeostasis, may play a role in intestinal immunity. May mediate the activation of the inflammatory and immune response by SCFAs in the gut, regulating the rapid production of chemokines and cytokines by intestinal epithelial cells. Exhibits an SCFA-independent constitutive G protein-coupled receptor activity.
  • 基因功能參考文獻:
    1. Gpr41 KO mice have hypertension of a vascular origin. PMID: 27664183
    2. the maternal microbiome influences Treg differentiation in the thymus of offspring through GPR41-mediated Aire expression PMID: 29021375
    3. that GPR41 and its ligands, short-chain fatty acids, may play an important role in the fine-tuning of insulin secretion in fed and fasting states PMID: 27550964
    4. Pharmacological and knockdown experiments showed that activation of sympathetic neurons by SCFA propionate involves SCFA receptor GPR41 linking to Gbetagamma-PLCbeta3-ERK1/2-synapsin 2 PMID: 22673524
    5. mediates beta cell glucose stimulated insulin secretion through Galphai/o sensitive pathway PMID: 26091414
    6. Results indicate that FFAR3 is expressed on postganglionic sympathetic and sensory neurons in both the autonomic and somatic peripheral nervous system PMID: 25637492
    7. FFAR3 is expressed in pancreatic beta cells and mediates an inhibition of insulin secretion by coupling to Gi-type G proteins. PMID: 25581519
    8. Data from transgenic mice suggest that Ffar3/Gpr41 and Ffar2/Gpr43 both act as sensors for short-chain fatty acids in enteroendocrine cells; Ffar3/Gpr41 appears to play this role alone in enteric neurons and Ffar2/Gpr43 alone in enteric leukocytes. PMID: 23885020
    9. Short-chain fatty acids activate GPR41 and on intestinal epithelial cells, leading to mitogen-activated protein kinase signaling and rapid production of chemokines and cytokines. These pathways mediate protective immunity and tissue inflammation in mice. PMID: 23665276
    10. GPR41 gene expression is mediated by internal ribosome entry site (IRES)-dependent translation of bicistronic mRNA encoding GPR40 and GPR41 proteins PMID: 22493486
    11. Short chain fatty acids and ketone bodies directly regulate GPR41-mediated sympathetic nervous system activity and thereby control body energy expenditure in maintaining metabolic homeostasis. PMID: 21518883
    12. Gpr41 is a regulator of host energy balance through effects that are dependent upon the gut microbiota PMID: 18931303
    13. In this review, the mechanism of receptor activation, pharmacology, and the physiological functions of the fatty acid binding receptors GPR40, GPR41, GPR43, and GPR119 are discussed. PMID: 19009545

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 組織特異性:
    Expressed in white adipose tissue and skeletal muscle (at protein level). Abundantly expressed in sympathetic ganglia such as the superior cervical ganglion. Also expressed by intestinal endocrine cells.
  • 數(shù)據(jù)庫鏈接:


主站蜘蛛池模板: 中文字幕av无码免费久久| 男女爽爽无遮挡午夜视频| 国产成人无码a区在线| 国产精品内射后入合集| 久久精品视频在线看| 亚洲精品suv精品一区二区| 天堂av男人在线播放| 亚洲精品少妇30p| 偷柏自拍亚洲综合在线| 亚洲精品无码久久久久yw| 影音先锋在线资源无码| 在线看亚洲十八禁网站| 丰满的少妇被猛烈进入白浆 | 狠狠色噜噜狠狠狠狠777米奇小说| 久久精品国产999久久久| 放荡的美妇在线播放| 超碰国产精品久久国产精品99 | 人人做人人爽久久久精品| 男女下面进入的视频| 一区二区视频| 日本另类αv欧美另类aⅴ| 人人爽久久久噜噜噜婷婷| 国产精品国产亚洲区艳妇糸列短篇 | 国产精品国产三级国产aⅴ下载| 人妻av中文系列| 日本少妇自慰免费完整版| 曰的好深好爽免费视频网站| 国产高潮抽搐喷水高清| 波多野结衣的av一区二区三区| 特级毛片内射www无码| 爆乳喷奶水无码正在播放| 亚洲成国产人片在线观看| 级r片内射在线视频播放| 成人影院yy111111| 成人午夜无码精品免费看| av无码国产在线观看岛国| 亚洲欧美日本韩国| 色鬼7777久久| 少妇人妻无码专区视频| 96亚洲精华国产精华精华液| 亚洲精品宾馆在线精品酒店|