Recombinant Mouse Elongation of very long chain fatty acids protein 5 (Elovl5)

in vitro E.coli expression system

中文名稱：

小鼠Elovl5重組蛋白
貨號：

CSB-CF806376MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

in vitro E.coli expression system
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

基因名：

Elovl5
Uniprot No.：

Q8BHI7
別名：

Elovl5; Elongation of very long chain fatty acids protein 5; 3-keto acyl-CoA synthase Elovl5; ELOVL fatty acid elongase 5; ELOVL FA elongase 5; Very long chain 3-ketoacyl-CoA synthase 5; Very long chain 3-oxoacyl-CoA synthase 5
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區(qū)域：

1-299
氨基酸序列

MEHFDASLSTYFKAFLGPRDTRVKGWFLLDNYIPTFVCSVIYLLIVWLGPKYMKNRQPFS CRGILQLYNLGLTLLSLYMFYELVTGVWEGKYNFFCQGTRSAGESDMKIIRVLWWYYFSK LIEFMDTFFFILRKNNHQITVLHVYHHATMLNIWWFVMNWVPCGHSYFGATLNSFIHVLM YSYYGLSSIPSMRPYLWWKKYITQGQLVQFVLTIIQTTCGVFWPCSFPLGWLFFQIGYMI SLIALFTNFYIQTYNKKGASRRKDHLKGHQNGSVAAVNGHTNSFPSLENSVKPRKQRKD
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. In conditions where the essential linoleic and alpha linoleic fatty acids are lacking it is also involved in the synthesis of Mead acid from oleic acid.
基因功能參考文獻：
1. These studies establish that Elovl5 activity regulates hepatic levels of FAs controlling PPARbeta activity, ATGL expression, and TG catabolism, but not FA oxidation. PMID: 24814977
2. knockdown of Elovl5, Fads1, or Fads2 decreased the level of Mead acid. PMID: 24184513
3. a novel link between Elovl5-mediated synthesis of 18:1,n-7 and GNG through the control of the mTORC2-Akt-FoxO1 pathway PMID: 23099444
4. Results establish a link between fatty acid elongation and hepatic glucose metabolism and suggest a role for regulators of Elovl5 activity in the treatment of diet-induced hyperglycemia. PMID: 20488798
5. Elovl5-induced changes in hepatic fatty acid content affect multiple pathways regulating hepatic lipid and carbohydrate composition PMID: 18376007
6. reduced ELOVL5 activity leads to hepatic steatosis, and endogenously synthesized PUFAs are key regulators of SREBP-1c activation and fatty acid synthesis in liver PMID: 18838740
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亞細胞定位：

Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell projection, dendrite.
蛋白家族：

ELO family, ELOVL5 subfamily
數(shù)據(jù)庫鏈接：

KEGG: mmu:68801

STRING: 10090.ENSMUSP00000034904

UniGene: Mm.430736