在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Calcium uniporter protein, mitochondrial (Mcu)-VLPs

  • 中文名稱:
    小鼠Mcu重組蛋白
  • 貨號:
    CSB-MP668882MO
  • 規格:
  • 其他:

產品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    Mcu; Calcium uniporter protein, mitochondrial
  • 種屬:
    Mus musculus (Mouse)
  • 來源:
    Mammalian cell
  • 表達區域:
    50-350aa
  • 氨基酸序列
    AHQRPASWQSVGAAYCSTVVPSDDVTVVYQNGLPVISVRLPSRRERCQFTLKPISDSVGVFLRQLQEEDRGIDRVAIYSPDGVRVAASTGIDLLLLDDFKLVINDLTYHVRPPKRDLLSHEDAATLNDVKTLVQQLYTTLCIEQHQLNKERELVERLEDLKQQLAPLEKVRIEISRKAEKRTTLVLWGGLAYMATQFGILARLTWWEYSWDIMEPVTYFITYGSAMAMYAYFVMTRQEYVYPEARDRQYLLFFHKGAKKSRFDLEKYNQLKDAIAQAEMDLKRLRDPLQVHLPLRQIGEKE
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    C-terminal 10xHis-tagged
    If you have specified tag type, please tell us and we will check if it’s possible to develop.
  • 產品提供形式:
    Lyophilized powder
    Note: We will default ship it in lyophilized form with normal bule ice packs. However, if you request to ship in liquid form, it needs to be shipped with dry ice, please communicate with us in advance and extra fees for dry ice and dry ice box will be charged.
  • 緩沖液:
    Lyophilized from PBS, 6% Trehalose, pH 7.4
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store the protein at -20°C/-80°C upon receiving it, and ensure to avoid repeated freezing and thawing, otherwise, it will affect the protein activity.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex). Activity is regulated by MICU1 and MICU2. At low Ca(2+) levels MCU activity is down-regulated by MICU1 and MICU2; at higher Ca(2+) levels MICU1 increases MCU activity. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes. While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells. Participates in mitochondrial permeability transition during ischemia-reperfusion injury. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults. Regulates synaptic vesicle endocytosis kinetics in central nerve terminal. Involved in antigen processing and presentation.
  • 基因功能參考文獻:
    1. the endothelial barrier was preserved in respiratory epithelium isolated from MCU-/- mice after exposure to IL-13. In the ovalbumin-model of allergic airway disease, MCU deficiency resulted in decreased apoptosis within the large airway epithelial cells. Concordantly, expression of the tight junction protein ZO-1 was preserved, indicative of maintenance of epithelial barrier function PMID: 29225050
    2. Results suggest that inhibition of MCU attenuates Abeta-induced mcroglial apoptosis, and that it does so through modulation of reactive oxygen species-mediated endoplasmic reticulum stress. Understanding the apparent links between endoplasmic reticulum stress, oxidative stress and MCU could lead to the development of therapeutic strategies targeting Abeta-mediated microglial death. PMID: 28939404
    3. These data indicate that Ca(2+) uptake via mitochondrial uniporter contributes to palmitic acid-induced apoptosis in mouse podocytes. PMID: 28181698
    4. MCU expression returned to physiological levels in visceral adipose tissue of patients after weight loss by bariatric surgery. Altered mitochondrial calcium flux in fat cells may play a role in obesity and diabetes and may be associated with the differential metabolic profiles of visceral and subcutaneous adipose tissue. PMID: 28790027
    5. Regulation of mitochondrial Ca(2+) suggests that MCU may play a pivotal role in the development of fibrosis and could potentially be a therapeutic target for pulmonary fibrosis. PMID: 28351840
    6. Reveal a distinct functional role for Cys-97 in mitochondrial reactive oxygen species sensing and regulation of MCU activity. PMID: 28262504
    7. The m-AAA protease associated with neurodegeneration limits MCU activity in mitochondria. PMID: 27642048
    8. Data show that the serine/threonine kinase LKB1 regulates mitochondrial calcium uniporter (MCU)-expression, mitochondria-dependent Ca2+ clearance, and thereby, presynaptic release properties. PMID: 27429220
    9. the Mcu-regulating Micu gene family profile differs substantially between neurons and astrocytes, while expression of Mcu itself is markedly different between CA3 and CA1 regions in the adult hippocampus. PMID: 26828201
    10. Absence of MCU expression does not affect basal cardiac function at either 12 or 20months of age in knockout mice. PMID: 26057074
    11. MCU is required to match energetics with contractile demand during stress. Deletion of Mcu protects against myocardial IR injury. PMID: 26119731
    12. Mice lacking MCU in the heart show no pathology. MCU selectively mediates acute mitochondria Ca2+ loading to augment ATP synthesis. PMID: 26119742
    13. MCU is necessary for complete physiological heart rate acceleration PMID: 25603276
    14. MCU-VDAC1 complex regulates mitochondrial Ca(2+) uptake and oxidative stress-induced apoptosis PMID: 25753332
    15. Chromatin immunoprecipitation and promoter reporter analyses revealed that the Ca2+ -regulated transcription factor CREB (cyclic adenosine monophosphate response element-binding protein) directly bound the MCU promoter and stimulated expression. PMID: 25737585
    16. chronic myocardial MCU inhibition leads to previously unanticipated compensatory changes. PMID: 26153425
    17. Tetrodotoxin-sensitive mitochondrial Ca(2+) influx was largely blocked by knockdown of MCU expression. PMID: 24719357
    18. Characterization of MCU deficient mice indicates that acute alterations in mitochondrial matrix calcium can regulate mammalian physiology. PMID: 24212091
    19. Exogenously expressed Mcu is mitochondrially localized and increases mitochondrial Ca(2+) levels following NMDA receptor activation, leading to increased mitochondrial membrane depolarization and excitotoxic cell death. PMID: 23774321
    20. The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit. MCU has the fine control of the mitochondrial calcium homeostasis. PMID: 23900286
    21. Data show that the recently-identified mitochondrial Ca(2+) uniporter, MCU, is required for depolarisation-induced mitochondrial Ca(2+) increases, and for a sustained increase in cytosolic ATP/ADP ratio. PMID: 22829870
    22. genomic, physiological, biochemical and pharmacological data firmly establish MCU as an essential component of the mitochondrial Ca(2+) uniporter PMID: 21685886
    23. data demonstrate that the 40-kDa protein identified is the channel responsible for ruthenium-red-sensitive mitochondrial Ca(2+) uptake, thus providing a molecular basis for this process of utmost physiological and pathological relevance PMID: 21685888
    24. Includes expression analysis of the mouse Ccdc109a (MCU) gene. PMID: 21685888
    25. In vivo silencing of CCDC109a (MCU) in mouse liver abolishes mitochondrial calcium uptake without perturbing gross liver anatomy, mitochondrial oxygen consumption or membrane potential. PMID: 21685886
    26. Ccdc109a was identified in this large-scale proteomics analysis as a mitochondrial protein broadly expressed in many mouse tissues. The human protein was also confirmed to localize to mitochondria. PMID: 18614015

    顯示更多

    收起更多

  • 亞細胞定位:
    Mitochondrion inner membrane; Multi-pass membrane protein.
  • 蛋白家族:
    MCU (TC 1.A.77) family
  • 組織特異性:
    Detected in heart muscle (at protein level). Expressed in skeletal muscle, heart, kidney, liver, brain, lung, white fat and spleen.
  • 數據庫鏈接:


主站蜘蛛池模板: 另类亚洲小说图片综合区| 日本熟妇浓毛hdsex| 九一九色国产| 精品久久久久久无码不卡| 欧美日韩国产亚洲沙发| 国产农村乱辈无码| 日本一卡2卡3卡4卡无卡免费网站 丰满少妇人妻无码专区 | 高清粉嫩无套内谢国语播放| 青青青青国产免费线在线观看| 日本亚洲欧美日韩国产ay| 亚洲精品aa片在线观看国产| 国产av无码专区亚汌a√| 国产精品久久久久9999| 亚洲综合色自拍一区| 亚洲一区波多野结衣在线| 亚洲最大无码av网站观看| 亚洲人成线无码7777| 午夜免费男女aaaa片| 国产又黄又爽又猛免费视频播放| 伊人久久综合成人网| 亚洲日韩精品射精日| 好男人在在线社区www在线影院 | 亚洲综合色区中文字幕| 国产乱子伦视频一区二区三区| 偷偷做久久久久网站| 97色伦综合在线欧美视频| 国产丰满人妻一区二区| 国产色爱av资源综合区| 国产欧美久久一区二区三区| 无码精品国产一区二区免费| 曰的好深好爽免费视频网站| 亚洲成av人片在线观看下载| 夜夜春夜夜爽| 无码任你躁久久久久久老妇| 奇米777四色在线精品| 成人网站免费高清视频在线观看 | 先锋影音xfyy5566男人资源| 欧美肥婆性猛交xxxx| 黑人巨大av无码专区| 激情内射亚洲一区二区三区爱妻| 久久超碰精品一夜七次郎|