在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 跨膜蛋白
  4. Recombinant Mouse B-cell antigen receptor complex-associated protein alpha chain (Cd79a)

Recombinant Mouse B-cell antigen receptor complex-associated protein alpha chain (Cd79a)

  • 中文名稱：
    Recombinant Mouse B-cell antigen receptor complex-associated protein alpha chain(Cd79a)
  • 貨號：
    CSB-CF004957MO
  • 規(guī)格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產(chǎn)品詳情

  • 基因名：
  • Uniprot No.：
  • 別名：
    Cd79a; Iga; Mb-1; B-cell antigen receptor complex-associated protein alpha chain; Ig-alpha; MB-1 membrane glycoprotein; Membrane-bound immunoglobulin-associated protein; Surface IgM-associated protein; CD antigen CD79a
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區(qū)域：
    29-220
  • 氨基酸序列
    LRVEGGPPSLTVNLGEEARLTCENNGRNPNITWWFSLQSNITWPPVPLGPGQGTTGQLFFPEVNKNHRGLYWCQVIENNILKRSCGTYLRVRNPVPRPFLDMGEGTKNRIITAEGIILLFCAVVPGTLLLFRKRWQNEKFGVDMPDDYEDENLYEGLNLDDCSMYEDISRGLQGTYQDVGNLHIGDAQLEKP
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.
  • 基因功能參考文獻：
    1. BCR activation is accompanied by asymmetric conformational changes, possibly promoting the binding of Igalpha and Igbeta to differently localized signaling complexes PMID: 24244439
    2. CD79a myeloid cells showed enhanced ability to promote primary tumor growth and metastasis. PMID: 24146823
    3. Data indicate that in the absence of DGKzeta, the threshold for B cell antigen receptor (BCR) signaling, measured as activation of the Ras-extracellular signal-regulated kinase (ERK) pathway, was markedly reduced in mature follicular B cells. PMID: 24129701
    4. Data show that the B cell antigen receptor (BCR) and Igalpha may be required for B cell survival because they function as adaptor proteins in a BAFFR signaling pathway leading to activation of Syk, indicating crosstalk between the two receptors. PMID: 23453634
    5. The mouse B cell-specific mb-1 gene encodes an immunoreceptor tyrosine-based activation motif (ITAM) protein that may be evolutionarily conserved in diverse species by purifying selection. PMID: 21688146
    6. endocytosed BCR sequentially regulates MAPK and Akt signaling pathways from intracellular compartments PMID: 21964606
    7. Data indicate that both the Igalpha and the Igbeta cytoplasmic domains alone are sufficient for trafficking to lysosomal compartments, and are unaffected by mutation of 4 amino acid residues within their respective ITAMs. PMID: 20837062
    8. Arginine 198 in the tail of the Igalpha subunit of the BCR is methylated by the protein arginine methyltransferase 1. Methylation negatively regulates the calcium and PI-3 kinase pathways of the BCR, promoting signals leading to B cell differentiation. PMID: 20231378
    9. The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways PMID: 11909947
    10. IgA deficiency in lymphotoxin-deficient (LT(-/-)) mice could be fully reversed by reconstitution with LT-expressing bone marrow, despite the absence of both LNs and PPs. PMID: 12006975
    11. The VHDJH recombination process at the IgH locus and the survival of pro-B cells that carry these rearrangements do not depend on the expression of Ig-alpha molecules. PMID: 12097390
    12. Selective adherence of IgA to murine Peyer's patch M cells: evidence for a novel IgA receptor. PMID: 12165508
    13. Data show that expression of endogenous mb-1 transcripts correlates most closely with early-B-cell factor (EBF) expression and negatively with Id1, an inhibitor of E2A protein function, linking regulation of the mb-1 gene with EBF and E2A. PMID: 12446773
    14. Retrovirally expressed human Pax-5 protein activates endogenous early B-cell-specific mb-1 genes in mouse plasmacytoma cells, but only when the promoter is hypomethylated. PMID: 12612069
    15. Ig-alpha immunoreceptor tyrosine-based activation motif (ITAM) tyrosines (Y182 and Y193) are necessary for efficient pre-B cell differentiation. PMID: 17163454
    16. MHC II structural requirements for mediation of cell death signaling in a murine B cell lymphoma with Igalpha/beta PMID: 18194817

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.
  • 組織特異性：
    B-cells.
  • 數(shù)據(jù)庫鏈接：


主站蜘蛛池模板： 3d动漫精品啪啪一区二区| 日韩精品一区二区三区中文| 日韩人妻中文无码一区二区七区| 国产精品无码专区久久久| 日本在线看片免费人成视频1000| 青青草国产精品一区二区| 120秒试看无码体验区| 99久久国产综合精品五月天| 青青草免费公开视频| 性做久久久久久免费观看| 少妇人妻综合久久中文字幕| 亚洲gv永久无码天堂网| 无码人妻日韩一区日韩二区| 久99久热只有精品国产15| 中文字幕无码精品亚洲35| 人妻无码一区二区不卡无码av| 日日噜噜夜夜狠狠久久无码区| 亚洲成αv人片在线观看| 色欲久久久中文字幕综合网| 久久精品午夜福利| 成在人av抽搐高潮喷水流白浆| 麻豆av字幕无码中文| 国产成人愉拍免费视频| 日本人与黑人做爰视频网站| 成在人线av无码免费| 2021国产精品一卡2卡三卡4卡| 熟妇丰满大屁股在线播放 | 天天爱天天做久久狼狼| 精品乱子伦一区二区三区| 国产精品久久久久久爽爽爽 | 色老99久久精品偷偷鲁| 国产日产韩国精品视频| 国产无套内射普通话对白| 欧美 国产 亚洲视频| 在线成 人av影院| 99在线在线视频观看| 成人欧美一区二区三区在线观看 | 久久久久无码中| 国产精品色拉拉| 手机国产乱子伦精品视频| 国产黄a三级三级三级av在线看|