在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Alkaline ceramidase 1 (Acer1)

  • 中文名稱:
    Recombinant Mouse Alkaline ceramidase 1(Acer1)
  • 貨號(hào):
    CSB-CF001151MO
  • 說(shuō)明書(shū):
  • 規(guī)格:
  • 來(lái)源:
    in vitro E.coli expression system
  • 其他:

產(chǎn)品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    Acer1; Asah3; Alkaline ceramidase 1; AlkCDase 1; Alkaline CDase 1; maCER1; Acylsphingosine deacylase 3; N-acylsphingosine amidohydrolase 3
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度:
    full length protein
  • 表達(dá)區(qū)域:
    1-273
  • 氨基酸序列
    MHVPGTRAKMSSIFAYQSSEVDWCESNFQHSELVAEFYNTFSNVFFLIFGPLMMFLMHPY AQKRTRCFYGVSVLFMLIGLFSMYFHMTLSFLGQLLDEISILWLLASGYSVWLPRCYFPK FVKGNRFYFSCLVTITTIISTFLTFVKPTVNAYALNSIAIHILYIVRTEYKKIRDDDLRH LIAVSVVLWAAALTSWISDRVLCSFWQRIHFYYLHSIWHVLISITFPYGIVTMALVDAKY EMPDKTLKVHYWPRDSWVIGLPYVEIQENDKNC
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Exhibits a strong substrate specificity towards the natural stereoisomer of ceramides with D-erythro-sphingosine as a backbone and has a higher activity towards very long-chain unsaturated fatty acids like the C24:1-ceramide. May also hydrolyze dihydroceramides to produce dihydrosphingosine. ACER1 is a skin-specific ceramidase that regulates the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes and more generally plays an important role in skin homeostasis.
  • 基因功能參考文獻(xiàn):
    1. Loss of Acer1 elevated the levels of various ceramides and sphingoid bases in the skin and caused progressive hair loss in mice. PMID: 29056331
    2. In conclusion, the present study unraveled ceramidase as a crucial player in sphingosine-induced platelet activation following GPVI-dependent signaling. PMID: 29395079
    3. novel alkaline ceramidase with a stringent substrate specificity and is selectively expressed in skin and may have a role in regulating the levels of bioactive lipids ceramide and sphingosine-1-p, as well as complex sphingolipids. PMID: 12783875
  • 亞細(xì)胞定位:
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Alkaline ceramidase family
  • 組織特異性:
    Highly expressed in skin. Weakly or not expressed in other tissues. Expressed by granular layer of interfollicular epidermis, sebaceous glands and infundibulum.
  • 數(shù)據(jù)庫(kù)鏈接:


主站蜘蛛池模板: 一道久在线无码加勒比| 婷婷综合久久中文字幕| 老熟女重囗味hdxx70星空| 少妇高潮一区二区三区99| 久久久久无码精品国产不卡| 国产特级毛片aaaaaa| 免费女人高潮流视频在线| 久久免费精品国产72精品| 婷婷五月俺也去人妻| 人妻精品久久无码区| 亚洲人成无码网站在线观看| 中文字幕无线码中文字幕免费| 高潮毛片又色又爽免费| 亚洲人成网站观看在线播放| 免费无码av片在线观看国产| 人人妻人人超人人| 性色av无码久久一区二区三区| 亚洲中文字幕无码爆乳| 精品夜夜澡人妻无码av| 色伊人亚洲综合网站| 国产成人av在线播放影院| 99亚洲精品自拍av成人| 丰满人妻精品国产99aⅴ| 亚洲日韩精品欧美一区二区| 天堂网在线最新版www中文网| 免费人成在线观看视频无码| 亚洲热妇无码av在线播放| 国产香蕉97碰碰久久人人| 扒开双腿疯狂进出爽爽爽| 亚洲精品综合五月久久小说| 国色天香网www在线观看| 欧洲亚洲色视频综合在线| 国产麻豆剧果冻传媒白晶晶| 亚洲熟妇av日韩熟妇在线 | 嫖妓丰满肥熟妇在线精品| 亚洲—本道 在线无码av发| 67194熟妇在线直接进入| 亚洲日韩中文字幕无码一区| 日本乱偷互换人妻中文字幕| 国产9 9在线 | 免费| 色久悠悠婷婷综合在线亚洲|