在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Acid ceramidase (Asah1), partial

  • 中文名稱:
    Recombinant Mouse Acid ceramidase(Asah1),partial
  • 貨號:
    CSB-CF895296MO
  • 規格:
    ¥5028
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
  • Uniprot No.:
  • 別名:
    Asah1; Asah; Acid ceramidase; AC; ACDase; Acid CDase; Acylsphingosine deacylase; N-acylethanolamine hydrolase ASAH1; N-acylsphingosine amidohydrolase
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Partial
  • 來源:
    in vitro E.coli expression system
  • 分子量:
    33.8kDa
  • 表達區域:
    19-141aa
  • 氨基酸序列
    QAQDVPPWTEDCRKSTYPPSGPTYRGPVPWHTINLDLPPYKRWHELLAQKAPALRILVNSITSLVNTFVPSGKLMKMVDQKLPGMIGSLPDPFGEEMRGIADVTGIPLGEIISFNIFYELFTM
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Has a higher catalytic efficiency towards C12-ceramides versus other ceramides. Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine. For the reverse synthetic reaction, the natural sphingosine D-erythro isomer is more efficiently utilized as a substrate compared to D-erythro-dihydrosphingosine and D-erythro-phytosphingosine, while the fatty acids with chain lengths of 12 or 14 carbons are the most efficiently used. Has also an N-acylethanolamine hydrolase activity. By regulating the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes. Also indirectly regulates tumor necrosis factor/TNF-induced apoptosis. By regulating the intracellular balance between ceramides and sphingosine, in adrenocortical cells, probably also acts as a regulator of steroidogenesis.
  • 基因功能參考文獻:
    1. cells deficient in acid ceramidase (aCDase) also exhibited defects in CCL5 induction, whereas cells deficient in sphingosine kinase-1 and -2 exhibited higher levels of CCL5. PMID: 21335555
    2. Mutagenesis leads to early embryonic lethality in homozygotes and progressive lipid storage disease in heterozygotes. PMID: 11829492
    3. biochemistry of acid ceramidase reaction with acid sphingomyelinase PMID: 12815059
    4. Acid and neutral sphingomyelinase, ceramide synthase, and acid ceramidase have roles in cutaneous aging PMID: 16026583
    5. These results provide the first characterization of the Acid Ceremidase promoter from any species and demonstrate that Kruppel-like factor 6 (KLF6) is one transcription factor involved in the regulation of AC gene expression. PMID: 16500425
    6. acid ceramidase is an essential factor required for embryo survival that functions by removing ceramide from the newly formed embryos, thus inhibiting the default apoptosis pathway PMID: 17264167
    7. AC is a critical regulator of prostate cancer progression by affecting not only tumor cell proliferation and migration but also responses to drug therapy PMID: 17881906

    顯示更多

    收起更多

  • 亞細胞定位:
    Lysosome. Secreted.
  • 蛋白家族:
    Acid ceramidase family
  • 組織特異性:
    Widely expressed.
  • 數據庫鏈接:


主站蜘蛛池模板: 欧美韩中文精品有码视频在线| 中文字幕一区日韩精品| 开心色婷婷色五月激情| 玩50岁四川熟女大白屁股直播| 加勒比东京热无码一区| 同性男男黄g片免费网站| 亚洲乱码精品久久久久..| 免费1级a做爰片观看| 国产乱人伦偷精品视频下| 久久精品国产亚洲不av麻豆| 欧美黑人巨大videos精品| 西西人体www大胆高清视频| 成人网站免费观看入口| 亚洲欧美国产双大乳头| 日本大片免费观看视频| 国产全是老熟女太爽了| 中文字幕日韩一区二区三区不卡| 九九综合九色综合网站| 日本亚洲欧美在线视观看| 精品无码成人久久久久久| 中文字幕人成无码人妻综合社区 | 亚洲精品www久久久久久 | 蜜桃日本免费观看mv| 久久午夜无码鲁丝片直播午夜精品| 亚洲成av人的天堂在线观看| av怡红院一区二区三区| 国产一区二区三区 韩国女主播| 狠狠色狠狠色狠狠五月| 精品人妻无码区二区三区| 色噜噜狠狠色综合日日| 亚洲中文无码人a∨在线导航| 国产精品白丝av网站| 99国产精品久久久久久久久久久 | 午夜寂寞少妇aaa片毛片| 青草久久人人97超碰| 婷婷五月综合色中文字幕| 国产亚州精品女人久久久久久| 爱性久久久久久久久| 欧亚乱熟女一区二区三区在线 | 国产大屁股喷水视频在线观看| 亚洲αⅴ无码乱码在线观看性色|