在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Acid ceramidase (Asah1), partial

In Stock
  • 中文名稱:
    Recombinant Mouse Acid ceramidase(Asah1),partial
  • 貨號:
    CSB-EP895296MO
  • 規格:
    ¥1836
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
  • Uniprot No.:
  • 別名:
    Asah1; Asah; Acid ceramidase; AC; ACDase; Acid CDase; Acylsphingosine deacylase; N-acylethanolamine hydrolase ASAH1; N-acylsphingosine amidohydrolase
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Partial
  • 來源:
    E.coli
  • 分子量:
    43.8kDa
  • 表達區域:
    19-141aa
  • 氨基酸序列
    QAQDVPPWTEDCRKSTYPPSGPTYRGPVPWHTINLDLPPYKRWHELLAQKAPALRILVNSITSLVNTFVPSGKLMKMVDQKLPGMIGSLPDPFGEEMRGIADVTGIPLGEIISFNIFYELFTM
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10XHis-GST-tagged and C-terminal Myc-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Has a higher catalytic efficiency towards C12-ceramides versus other ceramides. Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine. For the reverse synthetic reaction, the natural sphingosine D-erythro isomer is more efficiently utilized as a substrate compared to D-erythro-dihydrosphingosine and D-erythro-phytosphingosine, while the fatty acids with chain lengths of 12 or 14 carbons are the most efficiently used. Has also an N-acylethanolamine hydrolase activity. By regulating the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes. Also indirectly regulates tumor necrosis factor/TNF-induced apoptosis. By regulating the intracellular balance between ceramides and sphingosine, in adrenocortical cells, probably also acts as a regulator of steroidogenesis.
  • 基因功能參考文獻:
    1. cells deficient in acid ceramidase (aCDase) also exhibited defects in CCL5 induction, whereas cells deficient in sphingosine kinase-1 and -2 exhibited higher levels of CCL5. PMID: 21335555
    2. Mutagenesis leads to early embryonic lethality in homozygotes and progressive lipid storage disease in heterozygotes. PMID: 11829492
    3. biochemistry of acid ceramidase reaction with acid sphingomyelinase PMID: 12815059
    4. Acid and neutral sphingomyelinase, ceramide synthase, and acid ceramidase have roles in cutaneous aging PMID: 16026583
    5. These results provide the first characterization of the Acid Ceremidase promoter from any species and demonstrate that Kruppel-like factor 6 (KLF6) is one transcription factor involved in the regulation of AC gene expression. PMID: 16500425
    6. acid ceramidase is an essential factor required for embryo survival that functions by removing ceramide from the newly formed embryos, thus inhibiting the default apoptosis pathway PMID: 17264167
    7. AC is a critical regulator of prostate cancer progression by affecting not only tumor cell proliferation and migration but also responses to drug therapy PMID: 17881906

    顯示更多

    收起更多

  • 亞細胞定位:
    Lysosome. Secreted.
  • 蛋白家族:
    Acid ceramidase family
  • 組織特異性:
    Widely expressed.
  • 數據庫鏈接:


主站蜘蛛池模板: 无码人妻一区二区三区免费手机| 国产美女久久精品香蕉| 亚洲欧美国产制服图片区| 国产精品一区二区熟女不卡| 国产精品对白交换视频 | 亚洲精品久久中文字幕| 丰满无码人妻热妇无码区| 小鲜肉自慰网站| 天堂中文8资源在线8| 久久无码中文字幕无码| 18禁美女裸体无遮挡免费观看国产| 日韩激情无码不卡码| a片在线免费观看| 亚洲va在线va天堂xxxx| 亚洲第一福利网站在线观看| 少妇一边呻吟一边说使劲视频| 无码人妻丰满熟妇区免费| 亚洲日韩看片无码超清| 少妇被又大又粗又爽毛片久久黑人| 国产精品9999久久久久仙踪林| 精品国产小视频在线观看| 国产午夜不卡片免费视频| 好男人社区在线www| 久久久中文久久久无码| 国产高清女同学巨大乳在线观看| 久久国产亚洲高清观看| 精品人妻人人做人人爽 | 狠狠久久精品中文字幕无码| 性暴力欧美猛交在线播放| 亚洲www啪成人一区二区麻豆| 色婷婷五月综合久久| 日本乱理伦片在线观看中文| 色一情一乱一伦麻豆| 双腿张开被9个黑人调教影片| 色惰日本视频网站www| 熟女少妇丰满一区二区| 国产麻豆9l精品三级站| 国产无遮挡色视频免费观看性色| 亚洲6080yy久久无码产自国产| 国产精品美女一区二区视频| 国产 | 欧洲野花视频欧洲1|