在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse 5,6-dihydroxyindole-2-carboxylic acid oxidase (Tyrp1)

  • 中文名稱:
    小鼠Tyrp1重組蛋白
  • 貨號:
    CSB-CF025399MO
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    Tyrp1; Tyrp-1; 5,6-dihydroxyindole-2-carboxylic acid oxidase; DHICA oxidase; Brown locus protein; Catalase B; Tyrosinase-related protein 1; TRP; TRP-1; TRP1
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    25-537
  • 氨基酸序列
    QFPRECANIEALRRGVCCPDLLPSSGPGTDPCGSSSGRGRCVAVIADSRPHSRHYPHDGKDDREAWPLRFFNRTCQCNDNFSGHNCGTCRPGWRGAACNQKILTVRRNLLDLSPEEKSHFVRALDMAKRTTHPQFVIATRRLEDILGPDGNTPQFENISVYNYFVWTHYYSVKKTFLGTGQESFGDVDFSHEGPAFLTWHRYHLLQLERDMQEMLQEPSFSLPYWNFATGKNVCDVCTDDLMGSRSNFDSTLISPNSVFSQWRVVCESLEEYDTLGTLCNSTEGGPIRRNPAGNVGRPAVQRLPEPQDVTQCLEVRVFDTPPFYSNSTDSFRNTVEGYSAPTGKYDPAVRSLHNLAHLFLNGTGGQTHLSPNDPIFVLLHTFTDAVFDEWLRRYNADISTFPLENAPIGHNRQYNMVPFWPPVTNTEMFVTAPDNLGYAYEVQWPGQEFTVSEIITIAVVAALLLVAAIFGVASCLIRSRSTKNEANQPLLTDHYQRYAEDYEELPNPNHSMV
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin.
  • 基因功能參考文獻:
    1. Genetic modulators of IOP thus may be independently identified using the full array of BXD mice without concern for the presence of transillumination defect or mutations in Typr1 and/or Gpnmb. PMID: 27011731
    2. the results from the present study demonstrate that the MA extract increases melanogenesis through the upregulation of TRP-1 protein expression by post-transcriptional control in B16F10 cells PMID: 25872655
    3. Addition of a TRP-1-directed monoclonal antibody to the treatment protocol for B16F10 skin melanoma mediates eradication of subcutaneous lesions. PMID: 23203930
    4. analysis of tyrosinase-related protein 1 in mouse melanocytes at early embryonic stage PMID: 22705010
    5. GILT-deficient mice have an increase in TRP1-specific regulatory T (Treg) cells compared with TRP1-deficient mice, and depletion of Treg cells partially restores the ability of GILT-deficient TRP1-specific CD4(+) T cells to induce vitiligo. PMID: 21833020
    6. The Tyrp1b mutation modifies the pathways and gene networks in which Tyrp1 functions. PMID: 21976956
    7. DNA vaccination with a melanoma-shared antigen Trp1, combined with systemic TGF-beta blockade during the perioperative period of primary tumor resection, confers protection against B16 melanoma. PMID: 21289306
    8. both the Rab32/38 binding activity and VAMP7 binding activity of Varp are essential for trafficking of Tyrp1 in melanocytes but activation of Rab21 by the VPS9 domain is not necessary for Tyrp1 trafficking PMID: 21187289
    9. Tyrosinase-related protein 1 (Tyrp1) displayed enriched expression in the dorsal root ganglia, an inactivating mutation in the A/J mouse strain, and a null mutant found to be more resistant to thermal nociception compared to its wild-type counterpart. PMID: 20633051
    10. this study suggests that DHICA monomers are required to incorporate into the DHI polymer backbone of eumelanin, which highlights the important role of Dct in the regulation of DHICA-mediated antioxidation. PMID: 20123016
    11. We found that ionophore monensin (Mon) and the quaternary amine chloroquine (CQ) discriminate between the traffic routes of TRP-2 and TRP-1 PMID: 15707965
    12. used sequence polymorphisms to finely map the deletion breakpoints and identify strong candidate genes for the known phenotypes PMID: 16505357
    13. The presence of a distal Tyrp1 regulatory element, which specifies melanocyte-specific expression, supports the idea that separate regulatory sequences can mediate differential gene expression in melanocytes and RPE. PMID: 16934245
    14. the role of Tyrp1 mechanisms involved in the subsequent IOP elevation and optic nerve degeneration remain unclear PMID: 17608931
    15. NZG/Kgm mouse has two recessive pigmentation variant genes (oca2(p) and tyrp-1(b)) and that the tyrp-1(b) gene locus associates with large body size. PMID: 19293329
    16. Varp functions as the Rab32/38 effector that controls trafficking of Tyrp1 in melanocytes. PMID: 19403694
    17. Data demonstrate that endogenous tyrosinase-related protein-1 expression alters the functionality of the autoreactive T cell repertoire. PMID: 19561540

    顯示更多

    收起更多

  • 相關疾病:
    Defects in Tyrp1 are the cause of the brown (b) phenotype. Brown mice have a brown or hypopigmented coat.
  • 亞細胞定位:
    Melanosome membrane; Single-pass type I membrane protein. Melanosome.
  • 蛋白家族:
    Tyrosinase family
  • 組織特異性:
    Pigment cells.
  • 數據庫鏈接:


主站蜘蛛池模板: 精品无人乱码高清在线观看| 玩弄少妇人妻| 亚洲精品喷潮一区二区三区| 浮妇高潮喷白浆视频| 亚洲午夜成人久久久久久| 亚洲男人综合久久综合天堂| 2021亚洲国产成a在线| 国产精品区免费视频| 成在人线av无码免观看午夜网| 99re6热精品视频在线观看| 国产精品69人妻无码久久 | 抽插丰满内射高潮视频| 在线视频夫妻内射| 女人与牲口性恔配视频免费| 久久人人97超碰国产公开| 人妻丰满熟妇av无码区免| 亚洲成a人片在线观看无码下载| 久久亚洲人成电影网| 三级男人添奶爽爽爽视频| 人妻熟女一区| 亚洲成在人线av无码| 亚洲乱码在线卡一卡二卡新区豆瓣| 日本二区三区欧美亚洲国| 中文字幕乱码在线播放| www国产亚洲精品久久网站| 亚洲国产欧美在线看片一国产| 国产初高中生真实在线视频| 国产av无码专区亚洲a∨毛片| 黑人狠狠的挺身进入| 国产爽视频在线观看视频| 日本猛少妇色xxxxx猛叫| 欧美成人精品高清视频在线观看| 亚洲精品无码av中文字幕电影网站| 国产精品亚洲а∨无码播放不卡| 精品国产一区二区三区无码| 成年丰满熟妇午夜免费视频| 亚洲日产av中文字幕无码偷拍| 亚洲色无码中文字幕手机在线| 18禁免费无码无遮挡不卡网站| 国内精品卡一卡二卡三| 日本成熟少妇喷浆视频|